Allogeneic Hemopietic Stem Cell Transplants for the Treatment of B Cell Acute Lymphocytic Leukemia

Immune Reconstitution of CD4+T Cells after Allogeneic Hematopoietic Stem Cell Transplantation and its Correlation with Invasive Fungal Infection in Patients with Hematological Malignancies

“…Because application of a large dose of cytotoxic drugs and long-term immunosuppressive drugs in transplantation regimen affects immune reconstitution after Allo-HSCT, the patients after transplantation will suffer from a longer immunodeficiency so as to increase the susceptibility to pathogenic microorganism (Toubert et al, 2012;Lehrnbecher et al, 2013;Gu et al, 2014;Dong et al, 2014). IFI, a very common severe complication after Allo-HSCT, still has high incidence and mortality in the patients undergoing Allo-HSCT (Omer et al, 2013;Tacke et al, 2014), but not all patients will encounter IFI, suggesting that the sensitivity of patients undergoing Allo-HSCT to IFI exists individual difference due to some unknown factors.…”