Allogeneic T-cell apoptosis induced by interleukin-10–modified dendritic cells: A mechanism of prolongation of intestine allograft survival?

IL-10 Gene Modified Dendritic Cells Inhibit T Helper Type 1-Mediated Alloimmune Responses and Promote Immunological Tolerance in Diabetes

“…IL-10 has been shown to block DC maturation in vitro, markedly reducing expression of MHC and costimulatory molecules on DC. It is now accepted that signaling through the T-cell antigen receptor (TCR) alone can lead to allospecific T-cell anergy or apoptosis (20). It has been reported that il-10 gene modified DCs could induce antigenic-specific tolerance in autoimmune disease such as autoimmune myocarditis (21,22).…”

Adoptive infusion of tolerance dendritic cells prolongs survival of small intestine allografts in rats: systematic review and meta‐analysis

“…To our knowledge, there has not been a meta-analysis of the literature using similar criteria. We selected 11 studies according to the previously described inclusion criteria, all of which involved a rat small intestinal transplantation model (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). Nine of these studies were suitable for metaanalysis (9-11, 13, 15-19).…”

“…Especially in the drug intervention group, triptolide-cultured DC with low expression of CD80 and MHC-II performed the best through stimulating a lower proliferative response of allogeneic T cells (10). The most commonly used method was gene modification, related to IL-12, IL-10, myeloid differentiation factor 88 (MyD88), and suppressor of cytokine signaling (SOCS) (9,11,12,14,15,17,18). MyD88 is a key Tolllike receptor (TLR) signaling adaptor and plays an essential role in DC function.…”