Allogeneic transplantation of epidermal cell sheets followed by endoscopic submucosal dissection to prevent severe esophageal stricture in a porcine model

Kobayashi, Shinichiro; Kanai, Nobuo; Yamato, Masayuki; Eguchi, Susumu

doi:10.1016/j.reth.2022.06.008

Cited by 6 publications

(7 citation statements)

References 52 publications

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“…Steroid injection therapy and oral steroid administration are the mainstream. Many other clinical applications have also been developed, such as tissue shielding methods with polyglycolic acid sheet, autologous oral mucosal epithelial sheet transplantation, and stent placement [22][23][24][25][26]. However, it would be better if these preventive procedures are adopted before the stricture happens.…”

Section: Discussionmentioning

confidence: 99%

A novel risk score model of esophageal stricture for patients undergoing endoscopic submucosal dissection

Yan,

Yang,

Gao

et al. 2023

European Journal of Gastroenterology &Amp; Hepatology

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Background and purpose Endoscopic submucosal dissection (ESD) is a promising technique for superficial esophageal lesions. However, stricture is a frequent adverse complication. This study was performed to develop a precise and convenient score prediction model for esophageal strictures after ESD, and compare its efficacy with a previously published predictive model. Methods This study enrolled clinical data of patients who underwent esophageal ESD for superficial esophageal lesions. Possible risk factors for esophageal stricture were identified by univariate and multivariate logistic regression analysis. Then we developed a prediction model according to the Framingham system for the first time and presented a convenient table containing the risk probability for each patient. In addition, we validated our score model and the previously published model in our center. Results A total of 838 patients were enrolled in this study and 6 variables, including age, surgery time, location of the lesion, circumference of the lesion, longitudinal resection length, and depth of infiltration were comprised in the score model. The total score ranged from 0 to 16 points and the risk probability was presented in one concise table for each patient. Areas under receiver-operator characteristic curves for the prediction model were 0.715 in derivation group and 0.804 in validation group. Conclusion We designed and validated a prediction score model for esophageal stricture after ESD, which can be applied conveniently to stratify the stricture risk after esophageal ESD and may facilitate appropriate clinical decision-making for these patients.

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Section: Discussionmentioning

confidence: 99%

A novel risk score model of esophageal stricture for patients undergoing endoscopic submucosal dissection

Yan,

Yang,

Gao

et al. 2023

European Journal of Gastroenterology &Amp; Hepatology

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“…EMT seems unlikely to malfunction and appears to be an important component, but MT can present all its difficulties in a tumour‐like manner to a large number of anticancer drugs 27 . Important histological characteristics of different types of genes, different types of genes, such as other cancer drug clinical studies may be possible if the expression or histological characteristics of tumours are measured 28 . However, there was no research on the effect of CUL4B on platinum‐based chemotherapeutic drug resistance.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“… 27 Important histological characteristics of different types of genes, different types of genes, such as other cancer drug clinical studies may be possible if the expression or histological characteristics of tumours are measured. 28 However, there was no research on the effect of CUL4B on platinum‐based chemotherapeutic drug resistance. Our research has filled in that gap of knowledge and has found that CUL4B can affect the development of platinum‐based drug resistance through regulation of EMT.…”

Section: Discussionmentioning

confidence: 99%

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CUL4B increases platinum‐based drug resistance in colorectal cancer through EMT: A study in its mechanism

Luo

Wang

et al. 2022

J Cellular Molecular Medi

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Colorectal cancer (CRC) is globally the third most common and the second deadliest tumour in humans regardless of gender. 1 Some of its fatality can be attributed to its strong ties to genetics and environmental effects. In the past years, incidence and mortality of CRC has been steadily decreasing, partly accreditable to the health-conscious society's increased tumour surveillance and better treatment. 2 The typical CRC begins as an adenomatous polyp in the normal colonic epithelium as it accumulates mutations in known targetable oncogenes, tumour suppressor genes, and genes related to DNA repair. 3 CRC is subclassified into stage 0, stage I, stage II, stage III, and stage IV depending on its depth of invasion, lymph node involvement, and metastasis, with stage 0 being the earliest, while stage IV signifying the most advanced. The prognosis of CRC is directly related to its staging, as well as the treatment available. As a rule of thumb, stage 0 is curable through operation, stage II requires a combination of adjuvant chemotherapy or radiotherapy along with a wider surgical resection to improve the success rate of treatment. 4 Chemotherapy plays a pivotal role in CRC treatment regimens, specifically platinumbased chemotherapeutic agents. 5 Presently, there are many studies on the drug resistance in these platinum-based agents for CRC, including fields such as DNA repair, tumour stem cells and epithelialmesenchymal transition (EMT), tumour microenvironment, etc. 6

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“…Moreover, PNIPAAm exhibits extension and shrinkage below and above the transition temperature, respectively. The unique properties of PNIPAAm have been applied in various biomedical contexts, such as temperature-regulated drug and gene delivery systems [ [36] , [37] , [38] , [39] , [40] , [41] ], bioanalysis and biosensor devices [ [42] , [43] , [44] , [45] , [46] , [47] ], nano-actuators [ [48] , [49] , [50] , [51] ], bioseparation tools [ [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] ], cell-separation materials [ [32] , [33] , [34] , [64] , [65] , [66] , [67] , [68] , [69] , [70] ], cell culture substrates [ [71] , [72] , [73] , [74] , [75] , [76] , [77] ], and cell sheet therapy in diverse types of regenerative medicine [ 5 , [78] , [79] , [80] , [81] , [82] , [83] , [84] , [85] , [86] , [87] , [88] ]. Temperature-controlled cell adhesion and detachment were applied to cell separation procedures using PNIPAAm-modified substrates.…”

Section: Introductionmentioning

confidence: 99%

Temperature-modulated separation of vascular cells using thermoresponsive-anionic block copolymer-modified glass

Hirotani,

Nagase

2024

Regenerative Therapy

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Allogeneic transplantation of epidermal cell sheets followed by endoscopic submucosal dissection to prevent severe esophageal stricture in a porcine model

Cited by 6 publications

References 52 publications

A novel risk score model of esophageal stricture for patients undergoing endoscopic submucosal dissection

A novel risk score model of esophageal stricture for patients undergoing endoscopic submucosal dissection

CUL4B increases platinum‐based drug resistance in colorectal cancer through EMT: A study in its mechanism

Temperature-modulated separation of vascular cells using thermoresponsive-anionic block copolymer-modified glass

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