Allosteric modulation of exosite 1 attenuates polyphosphate-catalyzed activation of factor XI by thrombin

Polyphosphate as an antithrombotic target and hemostatic agent

“…50,54 Whereas exosite 1 of thrombin attenuates the binding of exosite 2 to PolyP, further inhibiting the formation of the ternary PolyP-FXIthrombin complex and the activation of FXI. 55 Lc-PolyP enhances the expression of platelet P-selectin, microaggregate formation, and platelet consumption in a way dependent on the contact pathway. 45…”