2024
DOI: 10.1101/2024.01.07.574534
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Allostery at a protein-protein interface harboring an intermolecular dynamic network

Sara Medina Gomez,
Suresh Kumar Vasa,
Rasmus Linser

Abstract: Motional properties of individual amino acids in proteins are strongly modulated by their specific surrounding. The dynamics of tightly interacting residues can form intramolecular dynamic networks, which influence various features of protein function and serve as an access point for their modulation within signaling cascades. However, the possible formation of intermolecular networks shared between natural or constructed interaction partners has escaped thorough experimental assessment. Here, using fast-MAS s… Show more

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