Aloe vera-Based Hydrogels for Wound Healing: Properties and Therapeutic Effects

Chelu, Mariana; Musuc, Adina Magdalena; Popa, Mónica; Moreno, Jose Calderon

doi:10.3390/gels9070539

Cited by 39 publications

(17 citation statements)

References 188 publications

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“…[ 23 ] After wound formation, inflammation mediates the balance between wound healing and fibrosis. [ 29 ] The use of anti-inflammatory agents aids in wound healing but also negatively affects cells that prevent fibrosis development. Fibroblasts and myofibroblasts play a crucial role in the development of fibrosis.…”

Section: Discussionmentioning

confidence: 99%

“…Fibroblasts and myofibroblasts play a crucial role in the development of fibrosis. [ 29 ] In one study, local application of AV was reported to result in prolonged retention of proinflammatory agents such as vascular endothelial growth factor (VEGF) in the tissue and a higher fibroblast density. [ 27 ] This study supports the results of local AV application for fibrosis in our study.…”

Section: Discussionmentioning

confidence: 99%

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The effects of topical aloe vera on an experimentally designed penile fracture model in rats

Girgin

2024

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: This study assessed the histopathological and oxidative effects of topical Aloe Vera (AV) on penile fractures (PF) formed experimentally in a rat model. METHODS: Forty Wistar albino rats (220-250 g) were used. The PF model was created experimentally with a number 15 lancet. Then, the rats were randomly and equally divided into five groups. In the first group (C), no incision was formed. In the second group (P), an incision was formed. In the third group (PR), the incision line was closed primarily. In the fourth group (PA), AV was locally applied onto the incision without suturing for three days. In the last group (PRA), AV was applied to the primary repair region for three days. All groups were compared to each other according to histopathological and biochemical data. RESULTS: Hyperemia-bleeding was observed to be suppressed in the PRA group compared to the other groups (p<0.001). Inflammation was observed only in Groups PR and PRA (p<0.001). Significant fibrosis was observed in the PA and PRA groups compared to the other groups (p<0.001). Superoxide Dismutase (SOD) and Glutathione (GSH) values increased in favor of Group PRA (p=0.009 and p=0.035, respectively). Total Oxidative Status (TOS) and Malondialdehyde (MDA) values decreased in favor of Group PA (p=0.036 and p=0.026, respectively). Tumor Necrosis Factor-alpha (TNF-α) and Interleukin-1 beta (IL-1ß) levels decreased mostly in the PRA group, but these changes did not reach statistical significance (p>0.05). CONCLUSION: Topical AV application reduces tissue inflammation and oxidative stress but appears to increase the development of fibrosis after PF.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The effects of topical aloe vera on an experimentally designed penile fracture model in rats

Girgin

2024

Ulus Travma Acil Cerrahi Derg

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“…This unique characteristic endows hydrogels with a sponge-like quality, allowing them to absorb and retain large amounts of water while retaining their shape and mechanical properties. Hydrogels can be synthesized from both natural and synthetic polymers, offering a wide range of options for tailoring their properties to suit specific applications [33,34].…”

Section: Hydrogelsmentioning

confidence: 99%

Biomaterials-Based Hydrogels for Therapeutic Applications

Chelu,

Magdalena Musuc

2024

Biomaterials in Microencapsulation

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Conventional therapeutic models based on the premise of a universal solution are facing a decrease in efficiency, emphasized by the large number of patients who show resistance or who do not respond positively to classic treatments. This perspective highlights the urgency for more precise approaches based on personalized treatments that are adaptable to the specific complexities and unique challenges faced by each patient. Hydrogels are biocompatible and biodegradable systems for well-controlled and targeted administration of therapeutic agents, being formed by 3D reticulated networks of water-soluble polymeric biomaterials, of natural, synthetic, or hybrid origin, with specific intrinsic and extrinsic properties. Due to the easily adjustable porous structure, hydrogels allow the encapsulation of macromolecular drugs, proteins, small molecules, cells, hormones, or growth factors in the gel matrix and their subsequent controlled release. The biomaterials used, the crosslinking methods, the design, and the functionalization strategies in obtaining hydrogels with improved properties are presented. The different possibilities of application are described transdermally, as dressing materials, oral, ocular, spray-able, or injectable, up to the intracellular level. This chapter extensively investigates the advances and unique advantages of hydrogels that enable effective, noninvasive, personalized treatments and provide greater patient comfort for a wide range of applications.

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“…Aloe vera (AV) belongs to the Liliaceae family, of which the best-known species is Aloe Barbadensis Miller [ 86 ]. Aloe vera extract helps to improve oral bioavailability and acts as a good bio-enhancer [ 87 ].…”

Section: Herbal Bioactives Loaded Nanoformulations For Oral Deliverymentioning

confidence: 99%

Chitosan in Oral Drug Delivery Formulations: A Review

Sangnim,

Dheer,

Jangra

et al. 2023

Pharmaceutics

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Nanoformulations have become increasingly useful as drug delivery technologies in recent decades. As therapeutics, oral administration is the most common delivery method, although it is not always the most effective route because of challenges with swallowing, gastrointestinal discomfort, low solubility, and poor absorption. One of the most significant barriers that medications must overcome to exert a therapeutic effect is the impact of the first hepatic transit. Studies have shown that controlled-release systems using nanoparticles composed of biodegradable natural polymers significantly improve oral administration, which is why these materials have attracted significant attention. Chitosan possesses a wide variety of properties and functions in the pharmaceutical as well as healthcare industries. Drug encapsulation and transport within the body are two of its most important features. Moreover, chitosan can enhance drug efficacy by facilitating drug interaction with target cells. Based on its physicochemical properties, chitosan can potentially be synthesized into nanoparticles, and this review summarizes recent advances and applications of orally delivered chitosan nanoparticle interventions.

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Aloe vera-Based Hydrogels for Wound Healing: Properties and Therapeutic Effects

Cited by 39 publications

References 188 publications

The effects of topical aloe vera on an experimentally designed penile fracture model in rats

The effects of topical aloe vera on an experimentally designed penile fracture model in rats

Biomaterials-Based Hydrogels for Therapeutic Applications

Chitosan in Oral Drug Delivery Formulations: A Review

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