Aloe Vera for treating acute and chronic wounds

Dat, Anthony; Poon, Flora; Pham, Kim B T; Doust, Jenny

doi:10.1002/14651858.cd008762

Cited by 13 publications

(25 citation statements)

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“…Aloe vera (AV) is a cactus-like perennial succulent that belongs to the Liliaceae Family that is usually cultivated in tropical areas [11]. It is the one of oldest medicinal substances that was used in wound healing [12].…”

Section: Doi: 107243/2055-091x-2-3mentioning

confidence: 99%

Effect of topical aloe vera on the process of healing of full-thickness skin burn: a histological and immunohistochemical study

Hamid¹,

Soliman²

2015

J Histol Histopathol

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Background: Skin burn is common universal problem that may lead to ugly scarring, serious handicapping. Availability of natural biological treatment to improve its outcome becomes concern of many researchers. Aim of study: To explore the effect of aloe vera on the angiogenesis process during healing of a fullthickness experimental skin burn. Materials and methods: Seventy rats were divided into three groups; control group (A), group B and group C. Group B was exposed to full-thickness (FT) skin burn. Group C was exposed to FT skin burn with application of local aloe vera (AV) gel. Each of group B and C was divided into 3 subgroups from which skin specimens were taken at 4,8,12 days. Skin specimenswere prepared for histological and immunohistochemical study by hematoxlyin and eosin (H&E), Masson`s trichrome (MT) and alpha smooth muscle actin (α-SMA). All data were measured morphometrically and statistically analyzed. Results: After 4 days from inducing FT burn, the initial necrosis and inflammation gradually replaced by increased granulation tissue (GT) on 8 th and 12 th day skin specimens. The collagen deposition of GT increased progressively to make a coarse dense bundles, meanwhile the newly formed capillaries (NFC) of GT were surrounded by pericytes that showed extensive expression of α-SMA early on 4 th and till 8 th day specimens and decreased on 12 th day specimens. AV-treated groups showed relative decrease of α-SMA detection especially in 8 th and 12 th day specimens together with a significant decrease in the inflammatory infiltrate in all phases as well as deposition of more mature and finer collagen fibers compared with burn per se specimens. Conclusion: In full-thickness skin burn, aloe vera shows a beneficial effect by reducing the inflammation significantly and providing a more mature granulation tissue which could accelerate healing and might produce a sound well-remodeled scar.

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Section: Doi: 107243/2055-091x-2-3mentioning

confidence: 99%

Effect of topical aloe vera on the process of healing of full-thickness skin burn: a histological and immunohistochemical study

Hamid¹,

Soliman²

2015

J Histol Histopathol

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“…The beneficial properties of the plant have been ascribed to the inner, colorless leaf gel that can function both orally and topically as an active immunomodulator. The gel of Aloe vera has been reported to stimulate wound-healing and skin hydration, induce hematopoiesis, and possess anti-diabetic, anti-carcinogenic, antimicrobial, anti-oxidant as well as anti-inflammatory activities (Dat et al, 2012;Hamman, 2008a;Im et al, 2010;Surjushe et al, 2008;Vazquez et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages

Budai

Varga

Milesz³

et al. 2013

Molecular Immunology

154

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a b s t r a c tAloe vera has been used in traditional herbal medicine as an immunomodulatory agent inducing antiinflammatory effects. However, its role on the IL-1␤ inflammatory cytokine production has not been studied. IL-1␤ production is strictly regulated both at transcriptional and posttranslational levels through the activity of Nlrp3 inflammasome. In this study we aimed to determine the effect of Aloe vera on the molecular mechanisms of Nlrp3 inflammasome-mediated IL-1␤ production in LPS-activated human THP-1 cells and monocyte-derived macrophages. Our results show that Aloe vera significantly reduced IL-8, TNF␣, IL-6 and IL-1␤ cytokine production in a dose dependent manner. The inhibitory effect was substantially more pronounced in the primary cells. We found that Aloe vera inhibited the expression of pro-IL-1␤, Nlrp3, caspase-1 as well as that of the P2X7 receptor in the LPS-induced primary macrophages. Furthermore, LPS-induced activation of signaling pathways like NF-B, p38, JNK and ERK were inhibited by Aloe vera in these cells.Altogether, we show for the first time that Aloe vera-mediated strong reduction of IL-1␤ appears to be the consequence of the reduced expression of both pro-IL-1␤ as well as Nlrp3 inflammasome components via suppressing specific signal transduction pathways. Furthermore, we show that the expression of the ATP sensor P2X7 receptor is also downregulated by Aloe vera that could also contribute to the attenuated IL-1␤ cytokine secretion. These results may provide a new therapeutic approach to regulate inflammasome-mediated responses.

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“…A Agência Nacional de Vigilância Sanitária (ANVISA) proibiu a comercialização de sucos e outros alimentos à base de Aloe vera devido ao relato de reações adversas (4) e visto que as evidências científicas são insuficientes para comprovar sua segurança (2,6). Além disso, não há estudos sistemáticos sobre a toxicologia do Aloe, considerando que estes são necessários para investigação de possíveis danos ao organismo.…”

Section: Métodounclassified

“…Feridas podem resultar de muitas doenças e podem ser classificadas como aguda ou crônica conforme tempo de existên-cia (2). Ferida aguda segue um processo de reparação previsível e persiste até 14 dias após intervenção cirúrgica ou trauma.…”

Section: Introductionunclassified

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O uso do Aloe sp (aloe vera) em feridas agudas e crônicas: revisão integrativa

Chini¹,

Mendes

Siqueira

et al. 2017

Aquichan

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RESUMOObjetivos: buscar evidências disponíveis na literatura sobre o uso de Aloe vera na cicatrização de feridas agudas e crônicas. Materiais e método: trata-se de uma revisão integrativa realizada nas bases de dados LILACS, PubMed e Scopus, no período de fevereiro a março de 2015. A busca resultou em 178 publicações. Resultados: sete estudos constituíram a revisão, os quais envolveram pessoas com feridas cirúrgicas de cesariana, feridas de episiotomia, queimaduras, área doadora de enxerto, feridas pós-hemorroidectomia e feridas fissuras anais crônicas. Evidenciou-se que Aloe vera promove a cicatrização de feridas, além de diminuir a dor em fissuras anais crônicas e queimaduras. Conclusões: Aloe vera representa uma nova terapêutica no tratamento de feridas, no entanto as evidências disponíveis sobre sua eficácia e segurança são insuficientes para legitimar o seu uso na cicatrização de feridas agudas e crônicas; portanto, não podem ser generalizadas. PALAVRAS-CHAVEAloe; cicatrização de feridas; ferimento e lesões; fitoterapia; plantas medicinais (Fonte: DeCS, BIREME). El uso del Aloe sp (sábila) en heridas agudas y crónicas: revisión integradora RESUMEN Objetivos: buscar evidencias disponibles en la literatura acerca del uso de Aloe sp (sábila) en la cicatrización de heridas agudas y crónicas. Materiales y método: se trata de una revisión integradora realizada en las bases de datos LILACS, PubMed y Scopus, en el periodo de febrero a marzo del 2015. La búsqueda resultó en 178 publicaciones. Resultados: siete estudios constituyeron la revisión, los cuales involucraron personas con heridas de cesárea, heridas de episiotomía, quemaduras, área donadora de injerto, heridas posthemorroidectomía y heridas fisuarias anales crónicas. Se evidenció que la sábila promueve la cicatrización de heridas, además de disminuir el dolor en fisuras anales crónicas y quemaduras. Conclusiones: la sábila representa una nueva terapéutica en el tratamiento de heridas; sin embargo, las evidencias disponibles sobre su eficacia y seguridad son ineficientes para legitimar su uso en la cicatrización de heridas agudas y crónicas; por lo tanto, no se pueden generalizar. PALABRAS CLAVEAloe; cicatrización de heridas; heridas y lesiones; fitoterapia; plantas medicinales (Fuente: DeCS, BIREME). 9O uso do Aloe sp (babosa) em feridas agudas e crônicas: revisão integrativa l Lucélia Terra Chini e outros Results: Seven studies were included in the review, which involved persons with surgical wounds from caesarean sections, episiotomy wounds, burns, graft donor areas, post-hemorrhoidectomy wounds and chronic anal fissure wounds. It has been shown that aloe vera helps wound healing, in addition to reducing pain in chronic anal fissures and burns. Conclusion: Aloe vera represents a new therapy in the treatment of wounds. However, the available evidence on its effectiveness and safety is insufficient to legitimize the use of aloe in healing acute and chronic wounds. Therefore, the findings cannot be generalized.

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Aloe Vera for treating acute and chronic wounds

Cited by 13 publications

References 13 publications

Effect of topical aloe vera on the process of healing of full-thickness skin burn: a histological and immunohistochemical study

Effect of topical aloe vera on the process of healing of full-thickness skin burn: a histological and immunohistochemical study

Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages

O uso do Aloe sp (aloe vera) em feridas agudas e crônicas: revisão integrativa

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