Aloe vera oral administration accelerates acute radiation-delayed wound healing by stimulating transforming growth factor-β and fibroblast growth factor production

Therapeutic effect of Aloe vera and silver nanoparticles on acid-induced oral ulcer in gamma-irradiated mice

“…8,9 In addition, AV stimulates PGE2, TGF-β-1 and bFGF production and induces angiogenesis, which play important roles in the maintenance of mucosal integrity and wound healing. 31 Moreover, AV enhances production of kGF-1 and VEGF by g ing ival fibroblasts 32 and maintaines the wound moisturized, promotes epithelial cell migration, and enhances collagen maturation. 33 AgNPs exerts its healing effect by decreasing bacterial and fungal count at wound site.…”

“…14,34 (Melayie, 2005 #32;Nasrollahi, 2011 #14). Moreover, AgNPs enhances the process of reepithelialization 31 , which can be attributed to the ability of down-regulating inflammatory response, decreasing cytokine and matrix metalloproteinases level and inducing apoptosis of inflammatory cells, leading to earlier wound healing. 35 The reduced number of activated fibroblasts and mature vascular endothelial cells at the 3rd day, which increased by the 7th day, was also detected in irradiated salivary glands and attributed to cell cycle arrest due to delay of the S phase.…”

Role of Glucomannans in Immunology

“…The authors concluded that the inflammatory response and healing of the lesions was reduced by the Aloe vera. Atiba et al (123) reported that application of Aloe vera gel to rats exposed to radiation was able to improve the acute radiation-delayed wound healing by increasing the transforming growth factor (TGF-β-1) and basic fibroblast growth factor (bFGF) production.…”

Could We Really Use Aloe Vera Food Supplements to Treat Diabetes?

“…In addition, in a small double-blind, placebo-controlled, crossover trial, freeze-dried aloe vera concentrate reduced the symptoms of interstitial cystitis (Czarapata 1995). Studies on internal use of various "gel" (i.e., inner leaf or its juice) products suggest anti-inflammatory (Störsrud et al 2009), antioxidant (Liu et al 2007;Yu et al 2009), hepatoprotective (Chandan et al 2007), hypoglycemic Kim et al 2009;Yongchaiyudha et al 1996), hypolipidemic (Kim et al 2009), immunomodulatory (Yu et al 2009), and vulnerary effects (Atiba et al 2011), as well as promotion of increased fat metabolism (Misawa et al 2008). Preparations derived from the plant and described as "freeze-dried juice … heated for 15 minutes at 80 degrees" or "liquid Aloe vera extract" have demonstrated in vitro bactericidal activity against a number of pathogenic organisms, including Candida albicans and Streptococcus spp.…”