Alopecia areata

Lipner, Shari R.; Scher, Richard K.

doi:10.1016/j.jaad.2018.01.051

Cited by 3 publications

(3 citation statements)

References 5 publications

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“…Lipner et al have reported that nail changes can be present in as high as 66.0% of patients with AA whereas the average prevalence is nearly 30.0%. 16 We have found nail changes in 35.7% of children presenting with AA. Nail changes in patients with AA are indicative of progression to AA subtotalis.…”

Section: Trichoscopy Findingsmentioning

confidence: 68%

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Assessment of prognostic markers of alopecia areata in pediatric patients

Nayak¹,

Bhatia²,

Namdeo³

2023

Int J Res Dermatol

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Alopecia areata (AA) is associated with impairment of psychological health being more pronounced in pediatric population. Hence, it becomes imperative to study the AA in pediatric population so that early diagnosis and adequate treatment can be initiated at early stage to prevent further morbidity associated with the condition. This observational study was conducted in the department of dermatology venereology and leprosy, SAIMS and PG institute, Indore, India after obtaining approval from the IEC. The study included 14 children with AA who visited the hospital over the period of 1 year. Results showed that Mean age of the patients was 8.8±3.423 years with M:F ratio of 3:4. AA subtotalis was found to be most frequent (57.1%). The mean duration of alopecia was reported to be 9.3±7.965 months. The most common finding was the presence of a single patch (35.7%) and 50% of subjects have had a single episode of the disease. 64.3% of children had involvement of multiple sites with scalp being the most common (85.7%). There is high prevalence of markers of disease severity and activity amongst pediatric patients with AA. High prevalence of nail changes, mark hair (64.3%), coudability hair (50.0%), yellow dots (42.8.0%), black dots (78.6%), S. vellus hair (28.6%) shows that children have high chance of AA progressing to severe forms. There is high prevalence of markers of disease severity and activity amongst pediatric patients with AA with AA subtotalis more common among children as compared to the patchy type.

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Section: Trichoscopy Findingsmentioning

confidence: 68%

“…Nail changes in patients with AA are indicative of progression to AA subtotalis. 16 In study, frequency of occurrence of nail changes has been found to be high amongst patients with subtotalis compared to those with patchy AA, although the difference was statistically non-significant.…”

Section: Trichoscopy Findingsmentioning

confidence: 82%

Assessment of prognostic markers of alopecia areata in pediatric patients

Nayak¹,

Bhatia²,

Namdeo³

2023

Int J Res Dermatol

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“…It has a non-sex-linked lifetime risk of about 1.7% and a prevalence of 0.1–0.2% among the general population. It is commonly seen as a small rounded patch or coin-sized hair loss on the scalp that is accompanied by anxiety, depression, and low self-esteem among some affected individuals [ 244 , 245 ]. When compared to healthy individuals, AA patients were found to have less immune privilege in their proximal anagen hair follicles.…”

Section: Role Of the Pi3k-akt-mtor And Related Network In Skin Develo...mentioning

confidence: 99%

The PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds

Roy

Boateng

Uddin

et al. 2023

Cells

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The dysregulated phosphatidylinositol-3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) signaling pathway has been implicated in various immune-mediated inflammatory and hyperproliferative dermatoses such as acne, atopic dermatitis, alopecia, psoriasis, wounds, and vitiligo, and is associated with poor treatment outcomes. Improved comprehension of the consequences of the dysregulated PI3K/Akt/mTOR pathway in patients with inflammatory dermatoses has resulted in the development of novel therapeutic approaches. Nonetheless, more studies are necessary to validate the regulatory role of this pathway and to create more effective preventive and treatment methods for a wide range of inflammatory skin diseases. Several studies have revealed that certain natural products and synthetic compounds can obstruct the expression/activity of PI3K/Akt/mTOR, underscoring their potential in managing common and persistent skin inflammatory disorders. This review summarizes recent advances in understanding the role of the activated PI3K/Akt/mTOR pathway and associated components in immune-mediated inflammatory dermatoses and discusses the potential of bioactive natural products, synthetic scaffolds, and biologic agents in their prevention and treatment. However, further research is necessary to validate the regulatory role of this pathway and develop more effective therapies for inflammatory skin disorders.

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The Lived Experience of Women with Alopecia: A Qualitative Study Investigating the Psychological, Social and Emotional Impact of Alopecia in a Sample of Greek Women

Katara,

Vlastos,

Theofilou

2023

TOPHJ

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Background: Alopecia is the most frequent cause of hair loss, burdening the patient's psychology through the aesthetic appearance and quality of life. Aims: The present research attempted to investigate the changes in the socio-emotional world of women with alopecia and their adaptation to all aspects of everyday life. Methods: A thematic qualitative analysis (with semi-structured interviews) was performed on 10 women with alopecia without any other underlying disease. The aim of the study is to record the experiential experience of each participant in order to enrich the literature on the quality of life of women with alopecia. Results: The overarching themes that emerged are four and include women's functioning and adaptability, environmental attitudes and expectations, women's attitudes towards treatment and, finally, the impact of the disease. Conclusion: In conclusion, although alopecia is not life-threatening, it seems to modify, at least initially, the way in which women re-adapt to their daily lives, to how they perceive social and partner relationships and themselves in terms of part of the work.

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Alopecia areata

Cited by 3 publications

References 5 publications

Assessment of prognostic markers of alopecia areata in pediatric patients

Assessment of prognostic markers of alopecia areata in pediatric patients

The PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds

The Lived Experience of Women with Alopecia: A Qualitative Study Investigating the Psychological, Social and Emotional Impact of Alopecia in a Sample of Greek Women

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