Alopécie cicatricielle à type de folliculite décalvante induite par l’erlotinib

Folliculitis Decalvans-like Alopecia During Treatment With EGFR Inhibitors for Lung Cancer: A Case Series of 6 Patients

“…In the 4 cases of FD induced by anti-EGFR reported in literature, the management was similar to our cases, with the prescription of oral antibiotic therapy in combination with topical steroids, and with a marked improvement reported after 3-4 weeks [4].…”

EGFR inhibitor-induced folliculitis decalvans: a case series and management guidelines

“…To the best of our knowledge, this is the first case series of patients who developed folliculitis decalvans during afatinib therapy. Our three patients join the group of a few described cases of folliculitis decalvans during anti-EGFR therapy, as summarised in Table 1, [2,[5][6][7][8][9][10][11]. In the literature reported cases of folliculitis decalvans, the median time from the start of EGFR inhibitors to the first symptoms of alopecia was 4 months (range: 1-23 months).…”

“…One of the challenges in management of folliculitis decalvans is the resistance to the therapy [ 4 ] or disease recurrence. Ineffective treatment of severe or progressive folliculitis decalvans may require a dose reduction [ 6 , 10 ] or in critical cases even a discontinuation of the anti-cancer drug until improvement is required [ 11 ]. This decision should be made cautiously and primarily the control of the underlying oncological disease should be considered [ 9 ].…”