Alpha-fetoprotein in the early neonatal period—a large study and review of the literature

Bader, David A.; Riskin, Arieh; Vafsi, O.; Tamir, A.; Peskin, Barry; Israël, Nicole; Merksamer, R; Dar, Hanna; David, Michèle

doi:10.1016/j.cccn.2004.06.020

Cited by 126 publications

(86 citation statements)

References 25 publications

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“…The serum concentration of AFP peaks in the 14 th week, declines considerably until delivery and returns to normal levels within the first year of life (15). Normal neonatal AFP levels are poorly defined and are directly influenced by birth weight and the duration of gestation (16).…”

Section: Discussionmentioning

confidence: 99%

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Giant Epignathus Teratoma Discovered at Birth: A Case Report and 7-Year Follow-Up

Carvalho

Nonaka

Elias³

et al. 2017

Braz. Dent. J.

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Teratomas are tumors composed by tissues derived from the three germ cell layers, and they are relatively uncommon in head and neck. The term epignathus has been applied to teratomas from the oropharynx. This paper reports the case of a giant epignathus teratoma discovered at birth, which was successfully managed and followed up for 7 years. A newborn boy presented a polypoid tumor mass exteriorizing through the mouth over a length of 9 cm, with some surface areas resembling skin and others exhibiting hair. Computed tomography showed that the mass arose deep from the left hemiface. Alpha-fetoprotein (AFP) levels were high (316,000 ng/mL). Surgery was performed and microscopic analysis confirmed the diagnosis of mature teratoma. Because of residual tumor and high AFP levels, the patient was submitted to chemotherapy, resulting in complete regression of the lesion and normalization of AFP levels. Surgical repair of a cleft palate was performed at 5 years of age. At 7 years of age, the patient was in good general health and showed no clinical signs of recurrence. Although epignathus is a rare condition, it should be diagnosed in the fetus as early as possible. Prenatal care provides unquestionable benefits, providing the early diagnosis of anomalies that can jeopardize the life of the fetus and contributing to the indication of cases that require treatment before birth. G i a n t E p i g n a t h u s T e r a t o m a D i s c o v e r e d a t B i r t h : A C a s e R e p o r t a n d 7 -Ye a r F o l l o w -U p

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Section: Discussionmentioning

confidence: 99%

“…Normal neonatal AFP levels are poorly defined and are directly influenced by birth weight and the duration of gestation (16). In a series of 260 newborns, AFP levels ranged from 15,700 to 146,500 ng/mL (15).…”

Section: Discussionmentioning

confidence: 99%

Giant Epignathus Teratoma Discovered at Birth: A Case Report and 7-Year Follow-Up

Carvalho

Nonaka

Elias³

et al. 2017

Braz. Dent. J.

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“…[1][2][3] The average concentration of AFP in healthy human serum is ,20 ng/mL, and serum AFP levels often increase in a number of disease states. 4 Therefore, detection of trace amounts of AFP is of great importance.…”

Section: Introductionmentioning

confidence: 99%

Fe3O4/Au magnetic nanoparticle amplification strategies for ultrasensitive electrochemical immunoassay of alfa-fetoprotein

Gan¹,

Jin²,

Li³

et al. 2011

IJN

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Background The purpose of this study was to devise a novel electrochemical immunosensor for ultrasensitive detection of alfa-fetoprotein based on Fe 3 O 4 /Au nanoparticles as a carrier using a multienzyme amplification strategy. Methods and results Greatly enhanced sensitivity was achieved using bioconjugates containing horseradish peroxidase (HRP) and a secondary antibody (Ab 2 ) linked to Fe 3 O 4 /Au nanoparticles (Fe 3 O 4 /Au-HRP-Ab 2 ) at a high HRP/Ab 2 ratio. After a sandwich immunoreaction, the Fe 3 O 4 /Au-HRP-Ab 2 captured on the electrode surface produced an amplified electrocatalytic response by reduction of enzymatically oxidized hydroquinone in the presence of hydrogen peroxide. The high content of HRP in the Fe 3 O 4 /Au-HRP-Ab 2 could greatly amplify the electrochemical signal. Under optimal conditions, the reduction current increased with increasing alfa-fetoprotein concentration in the sample, and exhibited a dynamic range of 0.005–10 ng/mL with a detection limit of 3 pg/mL. Conclusion The amplified immunoassay developed in this work shows good precision, acceptable stability, and reproducibility, and can be used for detection of alfa-fetoprotein in real samples, so provides a potential alternative tool for detection of protein in the laboratory. Furthermore, this immunosensor could be regenerated by simply using an external magnetic field.

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“…AFP is produced by the liver, and is used in the diagnosis of certain tumors and in children [8]. Circulating HCS concentrations correlate with early atherosclerosis, as early as the second decade of life and are associated with cardiovascular disease [9].…”

Section: Introductionmentioning

confidence: 99%

IMMULITE® 2000 age and sex-specific reference intervals for alpha fetoprotein, homocysteine, insulin, insulin-like growth factor-1, insulin-like growth factor binding protein-3, C-peptide, immunoglobulin E and intact parathyroid hormone

Soldin

Dahlin

Gresham

et al. 2008

Clinical Biochemistry

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Objectives-To determine age and sex-specific pediatric reference intervals for serum alpha fetoprotein, homocysteine, insulin, insulin-like growth factor-I, insulin-like growth factor binding protein-3, C-peptide, immunoglobulin E and parathyroid hormone.Design and methods-The study was conducted at both Children's National Medical Center and Georgetown University, Washington D.C. Results for the above analytes were obtained from the Children's National Medical Center laboratory information system over the period of 1/5/2001-3/8/2007.Patient results using the IMMULITE 2000® were accessed and used to establish reference intervals for the analytes studied. All patient identifiers were removed except age and sex. Analysis of the data was performed at Georgetown University in the Bioanalytical Core Laboratory. The data was analyzed using the Hoffmann approach, and was computer adapted. The number of patient samples studied varied with each analyte and were: Alpha fetoprotein (557), homocysteine (924), insulin-like growth factor-1 (1352), insulin-like growth factor binding protein-3 (711), insulin (3239), C-peptide (267), immunoglobulin E (2691) and parathyroid hormone (513).Results and conclusions-This study provides pediatric reference intervals for the eight analytes for children from birth to 18 years of age. All the analytes exhibited at least some age dependence. Sex differences between early and late childhood and adolescence were also frequently found.

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Alpha-fetoprotein in the early neonatal period—a large study and review of the literature

Cited by 126 publications

References 25 publications

Giant Epignathus Teratoma Discovered at Birth: A Case Report and 7-Year Follow-Up

Giant Epignathus Teratoma Discovered at Birth: A Case Report and 7-Year Follow-Up

Fe3O4/Au magnetic nanoparticle amplification strategies for ultrasensitive electrochemical immunoassay of alfa-fetoprotein

IMMULITE® 2000 age and sex-specific reference intervals for alpha fetoprotein, homocysteine, insulin, insulin-like growth factor-1, insulin-like growth factor binding protein-3, C-peptide, immunoglobulin E and intact parathyroid hormone

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