Alpha-Glycerylphosphorylcholine and D-Panthenol Eye Drops in Patients Undergoing Cataract Surgery

Abstract

Cataract surgery is widespread. The surgical procedure is associated with damage to the epithelial barrier and interruption of the corneal innervation. In addition, pathological events sustain signs and symptoms that may persist for a long time. Recently, a fixed combination of alpha-glycerylphosphorylcholine and D-Panthenol (Oftassiale) has been available as eye drops. The present study investigated the effects of an Oftassiale therapy in 20 patients undergoing cataract surgery. A comparison group included 20 patients treated with topical hyaluronic acid. Standard prophylactic and anti-inflammatory treatment was prescribed to all patients. Clinical signs and symptoms were assessed over time. In vivo confocal microscopy (IVCM) was performed accordingly. Oftassiale treatment significantly reduced clinical features and improved IVCM outcomes. In addition, therapy was well-tolerated, and no clinically significant adverse events occurred. In conclusion, this study confirmed that IVCM helps assess the tunnel after cataract surgery due to its ability to provide microscopic details in vivo. Topical therapy with alpha-glycerylphosphorylcholine and D-Panthenol eye drops promoted and stabilized the reepithelialization process. This fixed combination also accelerated and modulated the repair of the corneal innervation. Moreover, this treatment was well-tolerated and safe.

Efficacy of Dexpanthenol/Sodium Hyaluronate Fixed Combination Versus Sodium Hyaluronate Eye Drops for theTreatment of Dry Eye Disease and Ocular Surface Inflammation Following Cataract Surgery: A Comparative Study

“…In this study, dexpanthenol/alphaglycerylphosphorylcholine (Oftassiale ® , DMG, Italy) was applied to the study group, while sodium hyaluronate was applied to the control group for 1 month after cataract surgery; the dexpanthenol/alphaglycerylphosphorylcholine group had higher postoperative subbasal nerve plexus density, with fewer bead-like formations. 31 Similarly, coenzyme Q10 and trehalose/sodium hyaluronate eye drops have provided rapid nerve healing after cataract surgery. 32,33 Another leading cause of DED after cataract surgery is OSI.…”

“…33,35 In a previous study using dexpanthenol/alpha-glycerylphosphorylcholine drops, activated keratocyte and langerhans cell infiltrations were observed, particularly at the incision sites 1 month after surgery, and no difference was reported between study and control groups. 31 In another study, Cagini et al compared the efficacy of trehalose/sodium hyaluronate eye drops to a single dose of sodium hyaluronate in the treatment of postoperative DED and observed a statistically significant decrease in langerhans cell count, degree of keratocyte activation, nerve tortuosity, and reflectivity with trehalose/sodium hyaluronate eye drops. 33 In our study, we also observed a significant reduction in the number of dendritic cells, activated keratocytes, and the degree of nerve tortuosity, which are all indicators of OSI.…”