2010
DOI: 10.1016/j.neulet.2010.04.022
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Alpha-synuclein nitration and autophagy response are induced in peripheral blood cells from patients with Parkinson disease

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Cited by 66 publications
(43 citation statements)
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“…Interestingly, hsc70 down-regulation was also demonstrated in peripheral lymphomonocytes of sporadic PD patients (Sala et al, 2014; Papagiannakis et al, 2015). In these cells, a reduction of lamp2 (not lamp2A) protein levels and an increase of the autophagosome marker LC3-II were also reported (Prigione et al, 2010; Wu et al, 2011). This suggests the existence of a systemic alteration of autophagy in PD.…”
Section: Alterations Of Cma In Pdsupporting
confidence: 53%
See 1 more Smart Citation
“…Interestingly, hsc70 down-regulation was also demonstrated in peripheral lymphomonocytes of sporadic PD patients (Sala et al, 2014; Papagiannakis et al, 2015). In these cells, a reduction of lamp2 (not lamp2A) protein levels and an increase of the autophagosome marker LC3-II were also reported (Prigione et al, 2010; Wu et al, 2011). This suggests the existence of a systemic alteration of autophagy in PD.…”
Section: Alterations Of Cma In Pdsupporting
confidence: 53%
“…Post-translational modifications of wild-type asyn, such as oxidation, phosphorylation and nitration, are known to alter CMA activity, thus resulting in an inhibition of CMA-mediated asyn degradation, while dopamine-modification of asyn also impairs the degradation of other CMA substrates (Martinez-Vicente et al, 2008; Figure 1B). These modifications were largely found in PD brains (Fujiwara et al, 2002; Anderson et al, 2006) as well as in peripheral samples from patients (Prigione et al, 2010; Foulds et al, 2011). …”
Section: Alterations Of Cma In Pdmentioning
confidence: 99%
“…Impairment of the autophagy-lysosomal pathway has been shown to be related to the development of PD . Activation of autophagy was also identified within peripheral blood mononuclear cells from PD patients (Prigione et al, 2010). This self-regulatory concept of autophagy supports the hypothesis that increased signalling of autophagy occurred in mice with a malfunctioning lysosome that was accompanied by the aggregation of the protein α-synuclein (Meredith et al, 2002).…”
Section: Pq Induces Autophagysupporting
confidence: 75%
“…In peripheral blood mononuclear cells, two studies identified increased LC3-II levels, suggestive of autophagy activation (Table 1B) [123,171]. …”
Section: Dysfunction Of Autophagy In Parkinson’s Diseasementioning
confidence: 99%