ALSUntangled 45: Antiretrovirals

,

doi:10.1080/21678421.2018.1465248

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

2018

DOI: 10.1080/21678421.2018.1465248

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ALSUntangled 45: Antiretrovirals

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The Scientific and Therapeutic Rationale for Off‐Label Treatments in Amyotrophic Lateral Sclerosis

Bedlack,

Li,

Evangelista

et al. 2024

Annals of Neurology

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There are no dramatically effective pharmacological treatments for most patients with amyotrophic lateral sclerosis, a complex disease with multiple underlying mechanisms, such as neuroinflammation, oxidative stress, mitochondrial dysfunction, microbiome alteration, and antiretroviral activity. We sifted through 15 years of reviews by a group called ALSUntangled to identify 8 alternative and off‐label treatments that target ≥1 of these mechanisms, and have ≥1 human trial suggesting meaningful benefits. Given the overlapping pathological mechanisms of the highlighted products, we suggest that combinations of these treatments targeting diverse mechanisms might be worthwhile for future amyotrophic lateral sclerosis therapy development. ANN NEUROL 2024

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The Scientific and Therapeutic Rationale for Off‐Label Treatments in Amyotrophic Lateral Sclerosis

Bedlack,

Li,

Evangelista

et al. 2024

Annals of Neurology

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HIV related motor neuron disease/syndrome: The - potentially treatable - retroviral link in ALS?

Mochan

2019

Journal of the Neurological Sciences

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ALSUntangled 45: Antiretrovirals

Cited by 2 publications

References 47 publications

The Scientific and Therapeutic Rationale for Off‐Label Treatments in Amyotrophic Lateral Sclerosis

The Scientific and Therapeutic Rationale for Off‐Label Treatments in Amyotrophic Lateral Sclerosis

HIV related motor neuron disease/syndrome: The - potentially treatable - retroviral link in ALS?

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