ALSUntangled No. 34: GM604

Synthesis and pharmacological activity of vinpocetine derivatives

“… 23 In smooth muscle there are several forms of cyclic nucleotide phosphodiesterase's (PDE) and Vinpocetine inhibits one of them (Ca 2+ PDE) to relax smooth muscle demonstrated that Vinpocetine alleviates spasticity and reduces the presence of several inflammatory markers in amyotrophic lateral sclerosis (ALS), but the exact mechanism remains undiscovered. 24 In addition, the combination of Vinpocetine and nimodipine has been shown to be effective in myocardial infarction, and Vinpocetine has been found to inhibit osteogenic differentiation of VSMC by inducing phosphorylation of ERK and Akt to prevent vascular calcification. 25 Vinpocetine inhibits cellular senescence by significantly increasing insulin secretion from aged pancreatic islets and reducing oxidative stress and inflammation to break the vicious cycle of oxidative stress and senescence.…”