Alterações oculares e eletrorretinográficas na doença falciforme

David, Renato Cunha; Júnior, Haroldo Vieira de Moraes; Rodrigues, Márcio Penha Morterá

doi:10.1590/s0004-27492011000300009

Cited by 7 publications

(7 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous studies have shown the importance of ophthalmic evaluations in patients with SCA in order to prevent advanced eye disorders 23 . Cardiomegaly, myocardial ischemia, biventricular dysfunction and pulmonary hypertension are the most frequent clinical complications related to cardiovascular changes in sickle cell disease.…”

Section: Discussionmentioning

confidence: 99%

Clinical and laboratory profile of patients with sickle cell anemia

Sant’Ana

Araujo

Pimenta

et al. 2017

Revista Brasileira de Hematologia e Hemoterapia

View full text Add to dashboard Cite

ObjectiveThis study aimed to describe and analyze clinical and laboratory characteristics of patients with sickle cell anemia treated at the Hemominas Foundation, in Divinópolis, Brazil. Furthermore, this study aimed to compare the clinical and laboratory outcomes of the group of patients treated with hydroxyurea with those patients that were not treated with hydroxyurea.MethodsClinical and laboratorial data were obtained by analyzing medical records of patients with sickle cell anemia.ResultsData from the medical records of 50 patients were analyzed. Most of the patients were female (56%), aged between 20 and 29 years old. Infections, transfusions, cholecystectomy, splenectomy and systemic arterial hypertension were the most common clinical adverse events of the patients. The most frequent cause of hospitalization was painful crisis. The majority of patients had reduced values of hemoglobin and hematocrit (8.55 ± 1.33 g/dL and 25.7 ± 4.4%, respectively) and increased fetal hemoglobin levels (12 ± 7%). None of the clinical variables was statistically significant on comparing the two groups of patients. Among hematological variables only hemoglobin and hematocrit levels were statistically different between patients treated with hydroxyurea and untreated patients (p-value = 0.005 and p-value = 0.001, respectively).ConclusionSickle cell anemia requires treatment and follow-up by a multiprofessional team. A current therapeutic option is hydroxyurea. This drug reduces complications and improves laboratorial parameters of patients. In this study, the use of the drug increased the hemoglobin and hematocrit levels of patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical and laboratory profile of patients with sickle cell anemia

Sant’Ana

Araujo

Pimenta

et al. 2017

Revista Brasileira de Hematologia e Hemoterapia

View full text Add to dashboard Cite

show abstract

“…12 Maculopathy occurs as a result of chronic changes in the perifoveal capillary network. 8 According to David et al, 1 there was macular change in 14.4% of the patients. However, Clarkson found 4.6% of this same type of lesion.…”

Section: Ocular Manifestationsmentioning

confidence: 98%

“…5,7,12 Retinal changes characterize sickle cell retinopathy, which may be non-proliferative or proliferative and is divided into five stages. 1,10,12,13 Among the forms of sickle cell anemia, SS patients present a more severe systemic clinical picture than those with type SC. On the other hand, occlusive ocular effects are more predominant in SC patients, who present only moderate anemia and higher blood viscosity.…”

Section: Ocular Manifestationsmentioning

confidence: 99%

“…Sickle cell anemia is characterized by the production of abnormal hemoglobins that deform and stiffen red blood cells, causing increased blood viscosity and microcirculation occlusion to varying degrees. 1 These hemoglobins are insoluble at low oxygen concentrations, and tend to crystallize. 2 Sickle hemoglobin (HbS) is characterized by a mutation in the β-globin gene involving a single nucleotide (GAG à GTG) which replaces glutamine with valine in sixth amino acid position.…”

Section: Introductionmentioning

confidence: 99%

“…3,4 The most common genotypes are homozygous (SS), heterozygous or sickle cell trait (SA), hemoglobin C trait (SC), hemoglobin D trait (SD), and thalassemia genotype (S-Thal). 1,[5][6][7][8] The World Health Organization (WHO) estimates that more than 5% of the world population has some type of hemoglobinopathy. The estimate of new cases in Brazil is 700 to 1,000 per year, with a prevalence of over 2 million carriers of the HbS gene.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Sickle cell retinopathy: A literature review

Ribeiro

Jucá

Alves

et al. 2017

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

Hemoglobinopathies are a group of hereditary diseases that cause quantitative or qualitative changes in the shape, function or synthesis of hemoglobin. One of the most common is sickle cell anemia, which, due to sickling of erythrocytes, causes vaso-occlusive phenomena. Among the possible ocular manifestations, the most representative is retinopathy, which can lead to blindness if left untreated. Therefore, periodic ophthalmologic monitoring of these patients is important for early diagnosis and adequate therapeutic management, which can be done localy by treating the lesions in the eyes, or systemically.

show abstract

Ocular Manifestations in Egyptian Children and Young Adults with Sickle Cell Disease

El-Ghamrawy

Behairy

Menshawy

et al. 2014

Indian J Hematol Blood Transfus

View full text Add to dashboard Cite

In sickle cell disease (SCD), ocular lesions result from stasis and occlusion of small eye vessels by sickled erythrocytes. Vaso-occlusive disease of the retina can be responsible for nonproliferative (NPR) and proliferative retinopathy (PR). Patients are often asymptomatic until serious complications arise as, vitreous hemorrhage and retinal detachment. This work aimed to study the frequency and pattern of ocular manifestations in Egyptian children and young adults with SCD. In this cross-sectional study, 40 steady state patients (80 eyes) aged 2-28 years (30 children and 10 young adults) with established diagnosis of SCD (26 with homozygous SS and 14 with S/b thalassemia underwent complete ophthalmic examination with dilated fundoscopy. Fluorescein angiography was performed for patients C12 years old. The overall frequency of retinal lesions was 47.5 % (46.2 and 50 % of SS and S/b patients respectively). PR and NPR were evident in 32.5 and 27.5 % of all enrolled patients respectively (five patients having both). Peripheral retinal occlusion was a frequent ocular finding in both groups; the youngest patient showing PR was 15 years old. Older age, longer disease duration and splenectomy were significantly more prevalent among patients with PR. Despite lack of visual symptoms, children and young adults are at risk of PR. Frequency of retinal lesions was comparable in SS and S/b patients. Periodic ophthalmologic examination starting at the age of 12 years is recommended for timely-identification of retinal lesions thus minimizing the risk of sight threatening retinopathy.

show abstract

Alterações oculares e eletrorretinográficas na doença falciforme

Cited by 7 publications

References 17 publications

Clinical and laboratory profile of patients with sickle cell anemia

Clinical and laboratory profile of patients with sickle cell anemia

Sickle cell retinopathy: A literature review

Ocular Manifestations in Egyptian Children and Young Adults with Sickle Cell Disease

Contact Info

Product

Resources

About