Alteration in Serum Lipid Profile Pattern in Oral Squamous Cell Carcinoma and Potentially Malignant Disorders

Agrawal, Anchala; Nagarajappa, Anil Kumar; Bandela, Vinod; Agrawal, Gaurav; Chaturvedi, Shailendra Singh; Patil, Santosh

doi:10.1590/pboci.2021.077

Cited by 3 publications

(1 citation statement)

References 16 publications

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“…Different studies have indicated that abnormal levels of lipids are closely related to carcinogenesis and cancer metastasis. Malignant cancer cell proliferation requires high energy to transform and accelerate, leading to lipid metabolism alterations 7 . Some studies showed a decrease in plasma lipid levels in patients with cancer.…”

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confidence: 99%

Role of Vitamin D in the diagnosis of acute Myeloid Leukemia

Tahir

Thamer²,

Mahmood³

2023

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A range of hematological and biochemical markers have been investigated in Acute Myeloid Leukemia (AML) patients to determine the relationship between cancer growth and metabolic problems. This study aimed to determine the effects of vitamin D deficiency in Iraqi patients with acute myeloid leukemia who had recently been diagnosed. There was a significant inverse correlation between the total serum cholesterol (TC) level of acute myeloid leukemia (AML) patients group [(148.77±12.2) for males, (165.29±9.64) for females] and the control group [(164.50±7.26) for males, (180.05±7.31) for females], also an inverse correlation between high-density lipoprotein (HDL) level of acute myeloid leukemia (AML) patients group [(46.00±2.04) for males, (46.18±1.08) for females] and control group [(54.25±1.86) for males,(51.94±1.37) for females]. A significant difference was between the serum triglyceride (TG) level of acute myeloid leukemia (AML) patients group [(128.71±13.07) for males, (152.48±10.6) for females] and control group [85.12±11.30) for male, (90.50±10.90) for females], also between vitamin D level of acute myeloid leukemia (AML) patients group [(17.23±1.18) for males, (12.96±0.74) for females] and control group [(42.62±1.43) for males, (40.76±0.82) for females]. A statistically significant difference was between the serum calcium levels of individuals with acute myeloid leukemia [(8.99±0.32) for males, (8.91±0.23) for females] and the control group [(13.13±1.16) for males, (10.73±0.28) for females]. AML patients can benefit from vitamin D treatment, according to a pairwise analysis of receiver operating characteristic (ROC) curves. The above results are related to concluding that Vitamin D can be utilized as a diagnostic test for AML patients. Keywords; acute myeloid leukemia (AML), Hypereosinophilia, ROC curve, hypocholesterolemia, vitamin D.

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Section: Introductionmentioning

confidence: 99%

Role of Vitamin D in the diagnosis of acute Myeloid Leukemia

Tahir

Thamer²,

Mahmood³

2023

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Assessment of Lipid Profile in Oral Submucous Fibrosis: A Systematic Review and Meta‐Analysis

Gupta,

Sharma,

Hooda

et al. 2024

J Oral Pathology Medicine

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BackgroundAn altered blood lipid profile has been considered as a diagnostic and/or prognostic marker for cancer. Since oral cancer is usually preceded by oral potentially malignant disorders (OPMDs) and share common etiopathogenesis, thus researchers have tried to explore the role of blood lipid profile as a marker for OPMDs; however, no consensus has been made regarding the utilization of serum lipid profile as a biomarker for oral submucous fibrosis (OSMF). Thus, the present article aimed to validate serum lipid profile as a biomarker for OSMF.MethodologyPubMed, Scopus, Google Scholar and Clinical key databases were searched for relevant articles. Thirty‐six studies that met the eligibility criteria were included for qualitative review, however, out of these, 27 studies with specific data for OSMF and the control group were included in the meta‐analysis.ResultsA significant reduction in very low‐density lipoprotein (p = 0.042), low density lipoprotein (p = 0.006), high density lipoprotein (p = 0.020), triglyceride (p = 0.049) and total cholesterol (p = 0.009) levels in blood were observed in OSMF patients in comparison to healthy controls whereas no significant difference was seen in contrast to oral squamous cell carcinoma patients.ConclusionAlthough a significant alteration was observed in lipid levels in OSMF patients, considerable heterogeneity in all the studied parameters implies that blood lipid profile could not be used as a reliable biomarker for OSMF and require further investigation.

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Lipid Profile Estimation in Oral Malignant and Premalignant Lesions

Chowdhury

Kaushal²,

Mahendra³

et al. 2022

ijsr

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Introduction: Oral malignancy is usually preceded by lesions which are non-malignant to begin with and which are therefore been termed as premalignant. Many premalignant lesions and conditions like leukoplakia, erythroplakia, oral lichen planus, oral submucous brosis have malignant potentials. Aims: To evaluate the serum lipid prole in premalignant lesions and conditions like Oral Leukoplakia, Oral Submucous brosis and in Oral squamous cell carcinoma and its comparison with the lipid prole among control groups. Material and method: A total number of 225 patients were selected for the study from the OPD in Chandra Dental College and Hospital, Barabanki, U.P. the patients were selected under the criteria mentioned below. Patients with clinically evident and histopathologically conrmed with oral submucous brosis, oral lichen planus, oral leukoplakia, erythoplakia, and oral malignancy, for leukoplakia patients with histopathological conrmation sample collection was done, for patients with Oral Submucous Fibrosis after histopathological conrmation, sample collection was done and for Oral Malignancy sample collection was done after histopathological conrmation were included in this study. Result: In Control Group (1 Vs 3), the mean HDL (mean± s.d.) of patients was 72.9885± 8.6803. In Malignant Group (1 Vs 3), the mean HDL (mean± s.d.) of patients was 38.2000± 3.5106. Distribution of mean HDL with Group (1 Vs 3) was statistically signicant (p<0.0001). In Control Group (1vs3), the mean VLDL (mean± s.d.) of patients was 36.8640± 3.0412. In Malignant Group (1vs3), the mean VLDL (mean± s.d.) of patients was 26.1600± 1.5905. Distribution of mean VLDL with Group 1vs3 was statistically signicant (p<0.0001). In Control Group1 vs3, the mean LDL (mean± s.d.) of patients was 96.4448± 12.7468. In Malignant Group1 vs3, the mean LDL (mean± s.d.) of patients was 94.8000± 5.9233. Distribution of mean LDL with Group 1 Vs3 was not statistically signicant (p=0.3125). Conclusion: There was statistically signicant decrease in plasma total cholesterol, TG, LDL, VLDL and HDL observed in malignant patients as compared to the premalignant control group. The low lipid levels associated with Oral malignancy indicates that there is inverse relationship between oral cancer and serum lipid prole. Decrease in the lipid levels may be considered as a useful biochemical marker in the early diagnosis of oral malignancy.

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Alteration in Serum Lipid Profile Pattern in Oral Squamous Cell Carcinoma and Potentially Malignant Disorders

Cited by 3 publications

References 16 publications

Role of Vitamin D in the diagnosis of acute Myeloid Leukemia

Role of Vitamin D in the diagnosis of acute Myeloid Leukemia

Assessment of Lipid Profile in Oral Submucous Fibrosis: A Systematic Review and Meta‐Analysis

Lipid Profile Estimation in Oral Malignant and Premalignant Lesions

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