Alterations in Cerebral Hemodynamics During Microgravity: A Literature Review

Du, Jichen; Cui, Jian; Yang, Jing; Wang, Peifu; Zhang, Lvming; Luo, Bin; Han, Bailin

doi:10.12659/msm.928108

Cited by 15 publications

(14 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to cardiovascular function, the

ax parameter could be also useful for the assessment of cerebral drainage. Indeed, in challenging condition such as spaceflight,

showed a microG time-exposure relation, decreasing during flight permanence, followed by a normalization at return to the Earth [ 8 , 9 , 10 ]. Therefore, the use of this parameter becomes useful for monitoring the influence of exercise on cerebral venous drainage.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Effect of Submaximal Exercise on Jugular Venous Pulse Assessed by a Wearable Cervical Plethysmography System

et al. 2022

View full text Add to dashboard Cite

The jugular venous pulse (JVP) is a one of the crucial parameters of efficient cardiovascular function. Nowadays, limited data are available regarding the response of JVP to exercise because of its complex and/or invasive assessment procedure. The aim of the present work is to test the feasibility of a non-invasive JVP plethysmography system to monitor different submaximal exercise condition. Twenty (20) healthy subjects (13M/7F mean age 25 ± 3, BMI 21 ± 2) underwent cervical strain-gauge plethysmography, acquired synchronously with the electrocardiogram, while they were carrying out different activities: stand supine, upright, and during the execution of aerobic exercise (2 km walking test) and leg-press machine exercise (submaximal 6 RM test). Peaks a and x of the JVP waveform were investigated since they reflect the volume of cardiac filling. To this aim, the Δax parameter was introduced, representing the amplitude differences between a and x peaks. Significant differences in the values of a, x, and ax were found between static and exercise conditions (p < 0.0001, p < 0.0001, p < 0.0001), respectively. Particularly, the ax value for the leg press was approximately three times higher than the supine, and during walking was even nine times higher. The exercise monitoring by means of the novel JVP plethysmography system is feasible during submaximal exercise, and it provides additional parameters on cardiac filling and cerebral venous drainage to the widely used heartbeat rate value.

show abstract

“…In addition to cardiovascular function, the

ax parameter could be also useful for the assessment of cerebral drainage. Indeed, in challenging condition such as spaceflight,

Section: Discussionmentioning

confidence: 99%

“…It was demonstrated that the reduction of cardiac output in cosmonauts during long term exposure to micro-G is associated with cognitive alterations and visual disturbances. Microgravity exposure causes the shift of fluid to the upper part of the body, inducing an increase of intracellular and interstitial fluid volume [ 9 , 10 ]…”

Section: Introductionmentioning

confidence: 99%

The Effect of Submaximal Exercise on Jugular Venous Pulse Assessed by a Wearable Cervical Plethysmography System

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Consensus is lacking on the exact effects of microgravity on cerebrovascular regulation as the results from different models are inconsistent. Most of the interpretation of the data is based on patterns derived from other pathologies (Du et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Spaceflight-Associated Vascular Remodeling and Gene Expression in Mouse Calvaria

et al. 2022

View full text Add to dashboard Cite

Astronauts suffer from a loss of bone mass at a rate of 1.5% per month from lower regions of the body during the course of long-duration (>30 days) spaceflight, a phenomenon that poses important risks for returning crew. Conversely, a gain in bone mass may occur in non-load bearing regions of the body as related to microgravity-induced cephalad fluid shift. Representing non-load bearing regions with mouse calvaria and leveraging the STS-131 (15-day) and BION-M1 (30-day) flights, we examined spatial and temporal calvarial vascular remodeling and gene expression related to microgravity exposure compared between spaceflight (SF) and ground control (GC) cohorts. We examined parasagittal capillary numbers and structures in calvaria from 16 to 23 week-old C57BL/6 female mice (GC, n = 4; SF, n = 5) from STS-131 and 19–20 week-old C57BL/6 male mice (GC, n = 6; SF, n = 6) from BION-M1 using a robust isolectin-IB4 vessel marker. We found that the vessel diameter reduces significantly in mice exposed to 15 days of spaceflight relative to control. Capillarization increases by 30% (SF vs. GC, p = 0.054) in SF mice compared to GC mice. The vessel numbers and diameter remain unchanged in BION-M1 mice calvarial section. We next analyzed the parietal pro-angiogenic (VEGFA) and pro-osteogenic gene (BMP-2, DMP1, RUNX2 and OCN) expression in BION-M1 mice using quantitative RT-PCR. VEGFA gene expression increased 15-fold while BMP-2 gene expression increased 11-fold in flight mice compared to GC. The linkage between vascular morphology and gene expression in the SF conditions suggests that angiogenesis may be important in the regulation of pathological bone growth in non-weight bearing regions of the body. Short-duration microgravity-mediated bone restructuring has implications in planning effective countermeasures for long-duration flights and extraterrestrial human habitation.

show abstract

“…Some of these studies focused on the relationship between the internal pressure of the eye globe, i.e., the intraocular pressure (IOP), the pressure in the retrobulbar space (ICP), and blood pressure at eye level (especially arterial pressure) determining perfusion of the globe. However, despite previous investigations about cerebrovascular responsiveness during HDT [26,29,30], the link between cerebral hemodynamics (underlying ICP and eye arterial pressure) and the ocular apparatus is still poorly understood. The pressure difference between IOP and ICP, called ocular translaminar pressure (TLP), is believed to play a relevant role in the development of SANS.…”

Section: Introductionmentioning

confidence: 99%

Linking cerebral hemodynamics and ocular microgravity-induced alterations through an in silico-in vivo head-down tilt framework

Fois

Diaz‐Artiles

Zaman

et al. 2023

Preprint

View full text Add to dashboard Cite

Head-down tilt (HDT) has been widely proposed as terrestrial analogue of microgravity and used also to investigate the occurrence of the spaceflight associated neuro-ocular syndrome (SANS), which is currently considered one of the major health risks for human spaceflight. We propose here a novel, in vivo validated numerical framework to simulate the acute ocular-cerebrovascular response to 6° HDT and to explore the etiology and pathophysiology of SANS. The model links cerebral and ocular posture-induced hemodynamics, simulating the response of the main cerebrovascular mechanisms, as well as the relationship between intracranial and intraocular pressure to HDT. Our results from short-term (10 min) 6° HDT show increased hemodynamic pulsatility in the proximal-to-distal/capillary-venous cerebral direction, a marked decrease (-43%) in ocular translaminar pressure, and an increase (+31%) in ocular perfusion pressure, suggesting a plausible explanation of the underlying mechanisms at the onset of ocular globe deformation and edema formation over longer time scales.

show abstract

Alterations in Cerebral Hemodynamics During Microgravity: A Literature Review

Cited by 15 publications

References 52 publications

The Effect of Submaximal Exercise on Jugular Venous Pulse Assessed by a Wearable Cervical Plethysmography System

The Effect of Submaximal Exercise on Jugular Venous Pulse Assessed by a Wearable Cervical Plethysmography System

Spaceflight-Associated Vascular Remodeling and Gene Expression in Mouse Calvaria

Linking cerebral hemodynamics and ocular microgravity-induced alterations through an in silico-in vivo head-down tilt framework

Contact Info

Product

Resources

About