Alterations in genes other than &lt;i&gt;EGFR/ALK/ROS1&lt;/i&gt; in non-small cell lung cancer: trials and treatment options

Desai, Arpita; Menon, Sreedevi K.; Dy, Grace K.

doi:10.20892/j.issn.2095-3941.2016.0008

Cited by 21 publications

(11 citation statements)

References 34 publications

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“…The genes that typically drive lung ADC are consistent with these treatments and include epidermal growth factor receptor, anaplastic lymphoma kinase (ALK), and ROS-1 proto-oncogene 1. 12 The ESRPs are an evolutionarily conserved group of proteins with orthologs in nematodes and flies. 13 ESRP1 binds to the ISE/ISS-3 element and consists of three tandem RNA recognition motifs.…”

Section: Discussionmentioning

confidence: 99%

Epithelial Splicing Regulatory Protein 1 Inhibits the Invasion and Metastasis of Lung Adenocarcinoma

et al. 2018

The American Journal of Pathology

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Despite the development of various treatments, metastasis remains a significant problem with lung adenocarcinoma (ADC). The role and mechanism of epithelial splicing regulatory protein 1 (ESRP1), an epithelial-specific RNA binding protein, on promoting the invasion and metastasis of lung ADC remain to be fully elucidated. Immunohistochemical analysis in 125 human lung ADC tissue samples demonstrated that ESRP1 overexpression was inversely related to the presence of metastases, tumor size, and clinical stage of lung ADC. Impaired ESRP1 expression was also found to stimulate the invasion capacity of lung ADC cells both in vitro and in vivo. Functionally, overexpression of the ZEB1 gene decreased ESRP1 expression, and knockdown of the ZEB1 gene caused increased ESRP1 expression. On the basis of a gene array analysis, the expression of ESRP1 was associated with the regulation of the extracellular matrix. The expression of CD44 and fibroblast growth factor receptor, representatives that interact with the extracellular matrix, was studied. The CD44 subtypes promoted lung ADC cell invasion by regulating matrix metalloproteinase 2 expression. In conclusion, ESRP1 inhibits the invasion and metastasis of lung ADC and plays a role in regulating proteins involved in epithelial-to-mesenchymal transition.

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Section: Discussionmentioning

confidence: 99%

Epithelial Splicing Regulatory Protein 1 Inhibits the Invasion and Metastasis of Lung Adenocarcinoma

et al. 2018

The American Journal of Pathology

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“…In NSCLC, precisely adenocarcinoma, there are several targeted therapies developed to overcome the disequilibrium that leads to the transformation and abnormal behavior of cells. Mutations in epidermal growth factor receptor (EGFR), or other recombinant DNA processes in anaplastic lymphoma kinase (ALK) or c-ros oncogene 1 (ROS1) represent the main alterations that occur in patients diagnosed with NSCLC (7). Another important determinant in the development of the malignant phenotype in NSCLCs is represented by the noncoding part of the genome (8).…”

Section: Introductionmentioning

confidence: 99%

The Clinical Utility of miR-21 and let-7 in Non-small Cell Lung Cancer (NSCLC). A Systematic Review and Meta-Analysis

et al. 2020

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Non-small cell lung cancer (NSCLC) remains a problem worldwide due to its rapid progression and low rate of response to treatment. The heterogeneity of these tumors observed in histopathology exam but also in the mutational status and gene expression pattern makes this malignancy difficult to treat in clinic. The present study investigated the effect of miR-21 and let-7 family members as prognostic biomarkers in NSCLC patients based on the results published in different studies regarding this subject until March 2019. The analysis revealed that these two transcripts are steady biomarkers for prediction of patient outcome or survival. Upregulated expression of miR-21 is associated with poor outcome of patients with NSCLC [HR = 1.87, 95% CI = (1.41, 2.47), p < 0.001]. The analysis regarding let-7 family, specifically let-7a/b/e/f, revealed that downregulated expression of these transcripts predicts poor outcome for NSCLC patients [HR = 2.61, 95% CI = (1.58, 4.30), p < 0.001]. Besides, the reliability of these microRNAs is reflected in the fact that their prognostic significance is constant given the different sample types (tissue, FFPE tissue, serum, serum/plasma or exosomes) used in the selected studies.

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“…However, cytology specimens have been shown to be sufficient for molecular testing. Importantly, the use of cytology specimens for molecular testing prevents patient exposure to more invasive surgical procedures with a higher morbidity (16)(17)(18)(19).…”

Section: Discussionmentioning

confidence: 99%

Subtyping of Non-Small Cell Lung Carcinoma in Fine Needle Aspiration Specimens: A Study of 252 Patients with Surgical Correlations

Mollamehmetoğlu¹,

Koçak²,

Erdem³

et al. 2017

Eurasian J Pulmonol

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Objective: Fine-needle aspiration (FNA) cytology performed by either transthoracic or transbronchial procedures is an important approach to obtain tumor tissue for histological diagnosis. We investigated the accuracy of FNA in differentiating NSCLCs of adenocarcinoma from squamous cell carcinoma histological types to correlate cytological findings with histological features and immunohistochemistry confirmation in some cases. Methods:From 2010 to 2015, a total of 635 transbronchial needle aspirations or transthoracic needle aspirations were performed. 332 cases were diagnosed as NSCLC, with or without an indication of a specific subtype, while 303 cases were not diagnosed as NSCLC. Out of 332 cases diagnosed as NSCLC, 252 had a histological follow-up. Subsequently, histological samples included 161 surgical resections and 91 biopsies. In cases with histopathological diagnosis accompanied by FNA cytology, an immunohistochemical study was carried out and the diagnostic results of the two methods were compared to each other. Results:The specific subtype of NSCLC was provided in 217 cases (86%) based on cytomorphology which included 115 adenocarcinomas (46%) and 102 squamous cell carcinomas (40%). The diagnosis NSCLC-NOS by FNA was set in 35 cases. At histology, 251 cases (99.6%) were sub-classified: 122 adenocarcinomas (48%), 104 squamous cell carcinomas (41%), 11 large cell carcinomas (4%) , and 14 adenosquamous carcinomas (6%). Agreement between cytological and histological typing was found in 181 of 197 cases (92%) (K=0.837; p<0.001). Conclusion:Our study proved that most NSCLC can be sub-classified as adenocarcinoma or squamous cell carcinoma by FNA through cytomorphology and the application of immunocytochemistry.

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Alterations in genes other than <i>EGFR/ALK/ROS1</i> in non-small cell lung cancer: trials and treatment options

Cited by 21 publications

References 34 publications

Epithelial Splicing Regulatory Protein 1 Inhibits the Invasion and Metastasis of Lung Adenocarcinoma

Epithelial Splicing Regulatory Protein 1 Inhibits the Invasion and Metastasis of Lung Adenocarcinoma

The Clinical Utility of miR-21 and let-7 in Non-small Cell Lung Cancer (NSCLC). A Systematic Review and Meta-Analysis

Subtyping of Non-Small Cell Lung Carcinoma in Fine Needle Aspiration Specimens: A Study of 252 Patients with Surgical Correlations

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