Alterations in high-density lipoprotein proteome and function associated with persistent organic pollutants

Ljunggren, Stefan; Helmfrid, Ingela; Norinder, Ulf; Fredriksson, Mats; Wingren, Gun; Karlsson, Helén; Lindahl, Mattias

doi:10.1016/j.envint.2016.11.008

Cited by 20 publications

(16 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, advances in proteomics have extended the list of HDL-associated proteins, beyond the apolipoproteins associated to HDL, to over 85 suggesting that the composition of HDL is more complex than previously anticipated [69]. Studies have also shown that the levels of specific HDL-associated proteins are altered in disease states [86,87] and in polluted environments [88], and could therefore potentially also be used as disease biomarkers [89]. LDL and VLDL are also associated with a growing number of associated proteins that are known to have important functions in dyslipidemia, atherosclerosis, and coagulation disorders [90].…”

Section: Evs and Lipoproteins As Biomarkersmentioning

confidence: 99%

What is the blood concentration of extracellular vesicles? Implications for the use of extracellular vesicles as blood-borne biomarkers of cancer

Johnsen

Gudbergsson

Andresen

2019

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

210

169

View full text Add to dashboard Cite

Circulating biomarkers have a great potential in diagnosing cancer diseases at early stages, where curative treatment is a realistic possibility. In the recent years, using extracellular vesicles (EVs) derived from blood as biomarkers has gained widespread popularity, mainly because they are thought to be easy to isolate and carry a vast variety of biological cargos that can be analyzed for biomarker purposes. However, our current knowledge on the plasma EV concentration in normophysiological states is sparse. Here, we provide the very first mean estimate of the plasma EV concentration based on values obtained from a thorough literature review. The different estimates obtained from the literature are correlated to the isolation techniques used to obtain them, illustrating how some methodologies may over-or underestimate the plasma EV concentration. We also show that the estimated plasma EV concentration (approximately 10 10 EVs per mL) defines EVs as a minority population compared to other colloidal particles of the systemic circulation, namely the lipoproteins, which are known contaminants in EV isolates and carry biomarker molecules themselves. Lastly, we introduce the possibility of regarding EVs and lipoproteins as a continuum of lipid-containing particles to which biomarker molecules can be associated. Using such a holistic approach, increased strength of plasma-derived cancer biomarkers may soon be revealed.

show abstract

Section: Evs and Lipoproteins As Biomarkersmentioning

confidence: 99%

What is the blood concentration of extracellular vesicles? Implications for the use of extracellular vesicles as blood-borne biomarkers of cancer

Johnsen

Gudbergsson

Andresen

2019

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

210

169

View full text Add to dashboard Cite

show abstract

“…Biomarkers can also be used for studies of biochemical and biologicals effects (Angerer et al 2007). Collected samples of blood and urine in the present thesis have been used to evaluate biological effects in other studies (Ljunggren et al 2014;Ljunggren et al 2017) and will be used in further studies.…”

Section: Methodsmentioning

confidence: 99%

Exposure and body burden of environmental pollution and risk of cancer in a historically contaminated areas

Helmfrid

2019

Linköping University Medical Dissertations

Self Cite

View full text Add to dashboard Cite

This thesis is transdisciplinary, integrating toxicology, epidemiology and risk assessment, and involving academic institutions as well as national, regional and local authorities. Systematic and transparent methods for the characterization of human environmental exposure to site-specific pollutants in populations living in historically contaminated areas were used. Associations between environmental pollutant concentrations, exposure levels and observed or reported health effects were evaluated. Due to the uncertainty regarding exposure and health risks in populations living in contaminated areas, the authorities and some of the people living in the contaminated areas in Gusum village and in the "Kingdom of Crystal" in Nybro and Emmaboda, in the county of Kalmar, contacted the

show abstract

“…Of the lipoprotein particles, low-density lipoprotein (LDL) was found to be the main transporter of lipid-soluble POPs, but very-LDL (VLDL) and high-density lipoprotein (HDL) were also associated with lipid-soluble POPs in humans. 7 8 It was found that the highly chlorinated PCBs, being the most lipid-soluble PCBs, were more likely to be associated with lipoproteins compared to less chlorinated PCBs. In a follow-up study in the same sample, highly chlorinated PCBs were mainly related to HDL and to changes in several proteins linked to HDL function, such as cholesteryl ester transfer protein and phospholipid transfer protein.…”

Section: Lipid-soluble Pops and Circulating Lipoproteinsmentioning

confidence: 99%

“…In a follow-up study in the same sample, highly chlorinated PCBs were mainly related to HDL and to changes in several proteins linked to HDL function, such as cholesteryl ester transfer protein and phospholipid transfer protein. 8 …”

Section: Lipid-soluble Pops and Circulating Lipoproteinsmentioning

confidence: 99%

Are Persistent Organic Pollutants Linked to Lipid Abnormalities, Atherosclerosis and Cardiovascular Disease? A Review

Lind

2020

J Lipid Atheroscler

View full text Add to dashboard Cite

The term persistent organic pollutants (POPs) denotes chemicals with known or suspected adverse health effects in animals or humans and with chemical properties that make them accumulate in the environment, including animals or humans. Lipid-soluble POPs, like dioxins, polychlorinated biphenyls (PCBs) and organochlorine pesticides are transported by lipoproteins and accumulate in adipose tissue. High levels of these compounds in the circulation have been associated with elevated cholesterol and triglycerides in crosssectional studies and with an increase in mainly low-density lipoprotein cholesterol in a longitudinal study. Also, non-lipid-soluble POPs, such as perfluoroalkyl substances (PFASs) compounds have been associated with increased total cholesterol levels. Carotid artery atherosclerosis has been related to elevated levels of mainly highly chlorinated PCBs and to highly fluorinated PFASs, but in this case only in women. Both cross-sectional and prospective studies have shown dioxins, PCBs, as well as PFASs to be linked to cardiovascular disease (CVD) and mortality. In conclusion, as highlighted in this review, several lines of evidence support the view that POPs of different chemical classes could be linked to lipid abnormalities, carotid atherosclerosis and overt CVD like myocardial infarction and stroke.

show abstract

Alterations in high-density lipoprotein proteome and function associated with persistent organic pollutants

Cited by 20 publications

References 62 publications

What is the blood concentration of extracellular vesicles? Implications for the use of extracellular vesicles as blood-borne biomarkers of cancer

What is the blood concentration of extracellular vesicles? Implications for the use of extracellular vesicles as blood-borne biomarkers of cancer

Exposure and body burden of environmental pollution and risk of cancer in a historically contaminated areas

Are Persistent Organic Pollutants Linked to Lipid Abnormalities, Atherosclerosis and Cardiovascular Disease? A Review

Contact Info

Product

Resources

About