Alterations in immune cell heterogeneities in the brain of aged zebrafish using single-cell resolution

He, Jiangyong; Zhao, Fangying; Chen, Bingyue; Cui, Nianfei; Li, Zhifan; Qin, Jie; Luo, Lingfei; Zhao, Congjian; Li, Li

doi:10.1007/s11427-021-2223-4

Cited by 3 publications

(1 citation statement)

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“…The special group of macrophages is microglia, so these experiments could be used for detailed comparison with kidney-derived macrophages and resident macrophages from other tissues. We found six scRNAseq experiments derived from the brain of zebrafish: GSE130487 [49], GSE134706 [84], GSE137525 [85], GSE197673 [86], GSE228806 [66], GSE239410 [87]. This experiment is suitable for the reconstruction of the properties of glial cells (3/6), macrophages (3/6), B lymphocytes (2/6), and T lymphocytes (2/6) and presents clusters of dendritic cells, NK-like cells, and HSPCss.…”

Section: Cranial Neural Crest (1) E-curd-123mentioning

confidence: 99%

Fishing Innate Immune System Properties through the Transcriptomic Single-Cell Data of Teleostei

Bobrovskikh,

Zubairova,

Doroshkov

2023

Biology

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The innate immune system is the first line of defense in multicellular organisms. Danio rerio is widely considered a promising model for IIS-related research, with the most amount of scRNAseq data available among Teleostei. We summarized the scRNAseq and spatial transcriptomics experiments related to the IIS for zebrafish and other Teleostei from the GEO NCBI and the Single-Cell Expression Atlas. We found a considerable number of scRNAseq experiments at different stages of zebrafish development in organs such as the kidney, liver, stomach, heart, and brain. These datasets could be further used to conduct large-scale meta-analyses and to compare the IIS of zebrafish with the mammalian one. However, only a small number of scRNAseq datasets are available for other fish (turbot, salmon, cavefish, and dark sleeper). Since fish biology is very diverse, it would be a major mistake to use zebrafish alone in fish immunology studies. In particular, there is a special need for new scRNAseq experiments involving nonmodel Teleostei, e.g., long-lived species, cancer-resistant fish, and various fish ecotypes.

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