Alterations in Neural Networks During Working Memory Encoding Related to Cognitive Impairment in Temporal Lobe Epilepsy

Pan, Liping; Wu, Yakun; Bao, Jie; Guo, Dandan; Zhang, Xin; Wang, Jiajing; Deng, Meili; Yu, Peiran; Wei, Gaoxu; Zhang, Lulin; Qin, Xiao; Song, Yijun

doi:10.3389/fnhum.2021.770678

Cited by 7 publications

(3 citation statements)

References 72 publications

(99 reference statements)

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“…In addition to recurrent spontaneous seizures, patients with TLE often suffer from cognitive impairment. Up to 50%–80% of patients with TLE demonstrate impairment in at least one cognitive domain, most frequently in memory 6 . Other aspects of cognitive functioning have also been reported to be affected, including attention, executive function, judgment, insight, and problem solving 7–9 .…”

Section: Introductionmentioning

confidence: 99%

“…Up to 50%–80% of patients with TLE demonstrate impairment in at least one cognitive domain, most frequently in memory. 6 Other aspects of cognitive functioning have also been reported to be affected, including attention, executive function, judgment, insight, and problem solving. 7 , 8 , 9 These widespread cognitive consequences may cause a significant decline in the quality of life for TLE patients and are sometimes more debilitating than the seizures themselves.…”

Section: Introductionmentioning

confidence: 99%

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The role of the thalamus in modular functional networks in temporal lobe epilepsy with cognitive impairment

et al. 2023

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ObjectiveCognitive deficit is common in patients with temporal lobe epilepsy (TLE). Here, we aimed to investigate the modular architecture of functional networks associated with distinct cognitive states in TLE patients together with the role of the thalamus in modular networks.MethodsResting‐state functional magnetic resonance imaging scans were acquired from 53 TLE patients and 37 matched healthy controls. All patients received the Montreal Cognitive Assessment test and accordingly were divided into TLE patients with normal cognition (TLE‐CN, n = 35) and TLE patients with cognitive impairment (TLE‐CI, n = 18) groups. The modular properties of functional networks were calculated and compared including global modularity Q, modular segregation index, intramodular connections, and intermodular connections. Thalamic subdivisions corresponding to the modular networks were generated by applying a ‘winner‐take‐all’ strategy before analyzing the modular properties (participation coefficient and within‐module degree z‐score) of each thalamic subdivision to assess the contribution of the thalamus to modular functional networks. Relationships between network properties and cognitive performance were then further explored.ResultsBoth TLE‐CN and TLE‐CI patients showed lower global modularity, as well as lower modular segregation index values for the ventral attention network and the default mode network. However, different patterns of intramodular and intermodular connections existed for different cognitive states. In addition, both TLE‐CN and TLE‐CI patients exhibited anomalous modular properties of functional thalamic subdivisions, with TLE‐CI patients presenting a broader range of abnormalities. Cognitive performance in TLE‐CI patients was not related to the modular properties of functional network but rather to the modular properties of functional thalamic subdivisions.ConclusionsThe thalamus plays a prominent role in modular networks and potentially represents a key neural mechanism underlying cognitive impairment in TLE.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The role of the thalamus in modular functional networks in temporal lobe epilepsy with cognitive impairment

et al. 2023

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“…Patients with refractory TLE (rTLE) often have WM deficits with associated alterations in neural oscillation. 17 , 19 , 20 In this study, we examined the effects of chronic taVNS on WM in rTLE patients by performing EEG recordings during the encoding, maintenance, and retrieval phase of WM and analyzing changes in neural oscillations in the WM task state.…”

Section: Introductionmentioning

confidence: 99%

Transcutaneous auricular vagus nerve stimulation improves working memory in temporal lobe epilepsy: A randomized double‐blind study

Pan

Wang

et al. 2023

CNS Neurosci Ther

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AimsThis study investigated the impact of transcutaneous auricular vagus nerve stimulation (taVNS) on working memory (WM) in refractory temporal lobe epilepsy (rTLE) and the underlying mechanisms.MethodsIn this randomized double‐blind study, 28 rTLE patients were subjected to an active or sham taVNS (a/s‐taVNS) protocol for 20 weeks (a‐taVNS group, n = 19; s‐ta VNS group, n = 9). Patients performed visual WM tasks during stimulation and neural oscillations were simultaneously recorded by 19‐channel electroencephalography.ResultsCompared with the baseline state, reaction time was significantly shorter after 20 weeks of taVNS in the a‐taVNS group (p = 0.010), whereas no difference was observed in the s‐taVNS group (p > 0.05). The power spectral density (PSD) of the theta frequency band in the Fz channel decreased significantly after a‐taVNS during WM‐encoding (p = 0.020), maintenance (p = 0.038), and retrieval (p = 0.039) phases, but not in the s‐taVNS group (all p > 0.05).ConclusionNeural oscillations during WM were altered by taVNS and WM performance was improved. Alterations in frontal midline theta oscillations may be a marker for the effect of taVNS on cognitive regulation.

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Interactions between emotions and eating behaviors: Main issues, neuroimaging contributions, and innovative preventive or corrective strategies

Godet

Fortier

Bannier

et al. 2022

Rev Endocr Metab Disord

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Emotional eating is commonly defined as the tendency to (over)eat in response to emotion.Insofar as it involves the (over)consumption of high-calorie palatable foods, emotional eating is a maladaptive behavior that can lead to eating disorders, and ultimately to metabolic disorders and obesity. Emotional eating is associated with eating disorder subtypes and with Accepted manuscript / Final version abnormalities in emotion processing at a behavioral level. However, not enough is known about the neural pathways involved in both emotion processing and food intake. In this review, we provide an overview of recent neuroimaging studies, highlighting the brain correlates between emotions and eating behavior that may be involved in emotional eating.Interaction between neural and neuro-endocrine pathways (HPA axis) may be involved. In addition to behavioral interventions, there is a need for a holistic approach encompassing both neural and physiological levels to prevent emotional eating. Based on recent imaging, this review indicates that more attention should be paid to prefrontal areas, the insular and orbitofrontal cortices, and reward pathways, in addition to regions that play a major role in both the cognitive control of emotions and eating behavior. Identifying these brain regions could allow for neuromodulation interventions, including neurofeedback training, which deserves further investigation.

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Alterations in Neural Networks During Working Memory Encoding Related to Cognitive Impairment in Temporal Lobe Epilepsy

Cited by 7 publications

References 72 publications

The role of the thalamus in modular functional networks in temporal lobe epilepsy with cognitive impairment

The role of the thalamus in modular functional networks in temporal lobe epilepsy with cognitive impairment

Transcutaneous auricular vagus nerve stimulation improves working memory in temporal lobe epilepsy: A randomized double‐blind study

Interactions between emotions and eating behaviors: Main issues, neuroimaging contributions, and innovative preventive or corrective strategies

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