Alterations in regional homogeneity of baseline brain activity in pediatric temporal lobe epilepsy

Mankinen, Katariina; Long, Xiangyu; Paakki, Jyri-Johan; Harila, Marika; Rytky, Seppo; Tervonen, Osmo; Nikkinen, Juha; Starck, Tuomo; Remes, Jukka; Rantala, Heikki; Zang, Yu‐Feng; Kiviniemi, Vesa

doi:10.1016/j.brainres.2010.12.004

Cited by 75 publications

(62 citation statements)

References 53 publications

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“…Studies in patients with epilepsy reveal regions exhibiting increased ReHo, in line with the hypothesis of increased local synchronization of epileptic discharges [4,5] . ALFF measures the amplitude of fl uctuation of individual voxels [6] .…”

Section: Introductionsupporting

confidence: 72%

Local synchronization and amplitude of the fluctuation of spontaneous brain activity in attention-deficit/hyperactivity disorder: a resting-state fMRI study

et al. 2013

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Regional homogeneity (ReHo) and the amplitude of low-frequency fl uctuation (ALFF) are two approaches to depicting different regional characteristics of resting-state functional magnetic resonance imaging (RS-fMRI) data. Whether they can complementarily reveal brain regional functional abnormalities in attention-defi cit/hyperactivity disorder (ADHD) remains unknown. In this study, we applied ReHo and ALFF to 23 medication-naïve boys diagnosed with ADHD and 25 age-matched healthy male controls using whole-brain voxel-wise analysis. Correlation analyses were conducted in the ADHD group to investigate the relationship between the regional spontaneous brain activity measured by the two approaches and the clinical symptoms of ADHD. We found that the ReHo method showed widely-distributed differences between the two groups in the fronto-cingulo-occipitocerebellar circuitry, while the ALFF method showed a difference only in the right occipital area. When a larger smoothing kernel and a more lenient threshold were used for ALFF, more overlapped regions were found between ALFF and ReHo, and ALFF even found some new regions with group differences. The ADHD symptom scores were correlated with the ReHo values in the right cerebellum, dorsal anterior cingulate cortex and left lingual gyrus in the ADHD group, while no correlation was detected between ALFF and ADHD symptoms. In conclusion, ReHo may be more sensitive to regional abnormalities, at least in boys with ADHD, than ALFF. And ALFF may be complementary to ReHo in measuring local spontaneous activity. Combination of the two may yield a more comprehensive pathophy-siological framework for ADHD.

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Section: Introductionsupporting

confidence: 72%

Local synchronization and amplitude of the fluctuation of spontaneous brain activity in attention-deficit/hyperactivity disorder: a resting-state fMRI study

et al. 2013

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“…However, recent studies showed both increased and decreased changes in BOLD amplitude and connectivity measures (Centeno & Carmichael, 2014; Robinson et al., 2017). Our previous evidence in resting state fMRI also showed both increases and decreases in regional and long‐range connectivity measures in epilepsy (Mankinen et al., 2011, 2012). …”

Section: Discussionmentioning

confidence: 99%

Altered physiological brain variation in drug‐resistant epilepsy

et al. 2018

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IntroductionFunctional magnetic resonance imaging (fMRI) combined with simultaneous electroencephalography (EEG‐fMRI) has become a major tool in mapping epilepsy sources. In the absence of detectable epileptiform activity, the resting state fMRI may still detect changes in the blood oxygen level‐dependent signal, suggesting intrinsic alterations in the underlying brain physiology.MethodsIn this study, we used coefficient of variation (CV) of critically sampled 10 Hz ultra‐fast fMRI (magnetoencephalography, MREG) signal to compare physiological variance between healthy controls (n = 10) and patients (n = 10) with drug‐resistant epilepsy (DRE).ResultsWe showed highly significant voxel‐level (p < 0.01, TFCE‐corrected) increase in the physiological variance in DRE patients. At individual level, the elevations range over three standard deviations (σ) above the control mean (μ) CVMREG values solely in DRE patients, enabling patient‐specific mapping of elevated physiological variance. The most apparent differences in group‐level analysis are found on white matter, brainstem, and cerebellum. Respiratory (0.12–0.4 Hz) and very‐low‐frequency (VLF = 0.009–0.1 Hz) signal variances were most affected.ConclusionsThe CVMREG increase was not explained by head motion or physiological cardiorespiratory activity, that is, it seems to be linked to intrinsic physiological pulsations. We suggest that intrinsic brain pulsations play a role in DRE and that critically sampled fMRI may provide a powerful tool for their identification.

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“…Increased ReHo in type IIA may reflect enhanced synchronization of local epileptogenic circuits. 30 Such anomalies, reported in other focal syndromes 31,32 and generalized epilepsies, 33 suggest enhanced local connectivity as a common marker of chronic seizure activity. Conversely, decreased ReHo in type IIB may be specific to balloon cells, not necessarily a marker of epileptogenicity.…”

Section: Prediction Of Histologic Subtypesmentioning

confidence: 97%

Multimodal MRI profiling of focal cortical dysplasia type II

Hong¹,

Bernhardt²,

Caldairou³

et al. 2017

Neurology

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Objective: To characterize in vivo MRI signatures of focal cortical dysplasia (FCD) type IIA and type IIB through combined analysis of morphology, intensity, microstructure, and function. Methods:We carried out a multimodal 3T MRI profiling of 33 histologically proven FCD type IIA (9) and IIB (24) lesions. A multisurface approach operating on manual consensus labels systematically sampled intracortical and subcortical lesional features. Geodesic distance mapping quantified the same features in the lesion perimeter. Logistic regression assessed the relationship between MRI and histology, while supervised pattern learning was used for individualized subtype prediction.Results: FCD type IIB was characterized by abnormal morphology, intensity, diffusivity, and function across all surfaces, while type IIA lesions presented only with increased fluid-attenuated inversion recovery signal and reduced diffusion anisotropy close to the gray-white matter interface. Similar to lesional patterns, perilesional anomalies were more marked in type IIB extending up to 16 mm. Structural MRI markers correlated with categorical histologic characteristics. A profile-based classifier predicted FCD subtypes with equal sensitivity of 85%, while maintaining a high specificity of 94% against healthy and disease controls. Conclusions:Image processing applied to widely available MRI contrasts has the ability to dissociate FCD subtypes at a mesoscopic level. Integrating in vivo staging of pathologic traits with automated lesion detection is likely to provide an objective definition of lesional boundary and assist emerging approaches, such as minimally invasive thermal ablation, which do not supply tissue specimen. Neurology ® 2017;88:734-742 GLOSSARY ALFF 5 amplitude of low-frequency fluctuations; d-MRI 5 diffusion-weighted MRI; FA 5 fractional anisotropy; FCD 5 focal cortical dysplasia; FLAIR 5 fluid-attenuated inversion recovery; FWHM 5 full width at half maximum; GM 5 gray matter; MD 5 mean diffusivity; MNI 5 Montreal Neurological Institute; ReHo 5 regional homogeneity; rs-fMRI 5 resting-state functional MRI; SVM 5 support vector machine; TE 5 echo time; TR 5 repetition time; WM 5 white matter.

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Alterations in regional homogeneity of baseline brain activity in pediatric temporal lobe epilepsy

Cited by 75 publications

References 53 publications

Local synchronization and amplitude of the fluctuation of spontaneous brain activity in attention-deficit/hyperactivity disorder: a resting-state fMRI study

Local synchronization and amplitude of the fluctuation of spontaneous brain activity in attention-deficit/hyperactivity disorder: a resting-state fMRI study

Altered physiological brain variation in drug‐resistant epilepsy

Multimodal MRI profiling of focal cortical dysplasia type II

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