Alterations in spontaneous miniature potential activity during habituation of a vertebrate monosynaptic pathway

Effects of tap withdrawal response habituation on other withdrawal behaviors: The localization of habituation in the nematode Caenorhabditis elegans.

“…This work was extended to an analysis of spontaneous miniature potential release in cultured cells that suggested that the presynaptic mechanism of synaptic depression was mediated by a functional uncoupling of excitation and secretion rather than transmitter depletion (Eliot, Kandel, & Hawkins, 1994). These results were in accord with the results of Glanzman and Thompson (1980), who showed that the magnitude of spontaneous miniature potentials in the isolated frog spinal cord did not decrease as a consequence of habituation training of the lateral column/motor neuron monosynaptic pathway. Another example of this approach can be found in the analysis of habituation in the land slug Ariolimax.…”

Ethyl alcohol iphibits habituation of the nictitating membrane reflex response in the intact frog

“…Additionally, when GABAmediated presynaptic inhibition is blocked by picrotoxin in the lobster tail-flick preparation, the response habituates more rapidly than it does normally (Krasne & Roberts, 1969). From these data, and our own, a parsimonious model of presynaptic influences on habituation may be formed, which would conform to our current model of habituation (Glanzman & Thompson, 1979, 1980.…”

“…Similarly, Glanzman, Groves, and Thompson (1973) have shown, indirectly, that postsynaptic inhibition of spinal motoneurons in the acute spinal cat does not occur during the development of habituation. The majority of evidence now favors another mechanism of habituationhomosynaptic depression of those elements mediating the response (e.g., Glanzman & Thompson, 1979& Thompson, , 1980Kandel, 1976).…”