Alterations in the phosphodiesterase type 5 pathway and oxidative stress correlate with erectile function in spontaneously hypertensive rats

He, Weixiang; Liu, Jianmin; Liu, Daoquan; Hu, Jundong; Jiang, Ye; Li, Mingzhou; Wang, Qian; Chen, Ping; Zeng, Guang; Xu, Dongmei; Wang, Xinghuan; DiSanto, Michael E.; Zhang, Xinhua

doi:10.1111/jcmm.16045

Cited by 3 publications

(1 citation statement)

References 61 publications

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“…The contraction and relaxation of smooth muscle is the key event in the erection process 46 , 47 . Unlike rats, human smooth muscle bundles are larger and occupy most of the space in the cavernosal trabecular region, rather than being banded in the subendothelial region 40 .…”

Section: Discussionmentioning

confidence: 99%

Single-cell transcriptome atlas of the human corpus cavernosum

Zhao

Han

et al. 2022

Nat Commun

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The corpus cavernosum is the most important structure for penile erection, and its dysfunction causes many physiological and psychological problems. However, its cellular heterogeneity and signalling networks at the molecular level are poorly understood because of limited access to samples. Here, we profile 64,993 human cavernosal single-cell transcriptomes from three males with normal erection and five organic erectile dysfunction patients. Cell communication analysis reveals that cavernosal fibroblasts are central to the paracrine signalling network and regulate microenvironmental homeostasis. Combining with immunohistochemical staining, we reveal the cellular heterogeneity and describe a detailed spatial distribution map for each fibroblast, smooth muscle and endothelial subcluster in the corpus cavernosum. Furthermore, comparative analysis and related functional experiments identify candidate regulatory signalling pathways in the pathological process. Our study provides an insight into the human corpus cavernosum microenvironment and a reference for potential erectile dysfunction therapies.

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Section: Discussionmentioning

confidence: 99%

Single-cell transcriptome atlas of the human corpus cavernosum

Zhao

Han

et al. 2022

Nat Commun

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Alterations in the phosphodiesterase type 5 pathway and oxidative stress correlate with erectile function in spontaneously hypertensive rats

Liu

et al. 2020

J Cellular Molecular Medi

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Elucidating the Signaling Pathways Involved in Erectile Dysfunction

Kaya-Sezginer,

Celik,

Kirlangic

2024

CST

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Background: Erectile Dysfunction (ED) is a common sexual disorder among men aged 20 years and over. It is predominantly characterized by alterations in the key physiological pathways regulating erectile function, such as nitric oxide and Ras homolog gene family member A (RhoA)/Rho-associated protein kinase (ROCK). Beyond these pathways, multiple molecular signaling networks are involved in ED pathogenesis. Objective: This review aims todescribe the major signal transduction pathways that impact erectile function and contribute to the introduction of the pathogenesis of ED. Methods: A literature review of ED was performed from 2000 to 2023 using PubMed, Scopus, and Embase. “ED” and “related signaling pathway”, “molecular mechanisms” terms were used. Results: Further basic and clinical studies are required to define the underlying molecular mechanisms of ED. The signaling pathways that were not affected by phosphodiesterase type 5 inhibitors (PDE5i) may be the reason for the reduced efficacy of this first-line treatment option in a variety of conditions. Conclusion: There is still a need for a deeper description of the molecular mechanisms in terms of fibrosis, angiogenesis, apoptosis, inflammation, oxidative stress, autophagy, and hypoxia to identify new possible targets underlying the pathogenesis of ED. This comprehensive review expounds on the principal signaling pathways, offering valuable insights that may catalyze the development of innovative and enhanced therapies for managing ED.

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Alterations in the phosphodiesterase type 5 pathway and oxidative stress correlate with erectile function in spontaneously hypertensive rats

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 3 publications

References 61 publications

Single-cell transcriptome atlas of the human corpus cavernosum

Single-cell transcriptome atlas of the human corpus cavernosum

Alterations in the phosphodiesterase type 5 pathway and oxidative stress correlate with erectile function in spontaneously hypertensive rats

Elucidating the Signaling Pathways Involved in Erectile Dysfunction

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