2019
DOI: 10.1007/s10096-019-03598-9
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Alterations in the skin microbiome are associated with disease severity and treatment in the perioral zone of the skin of infants with atopic dermatitis

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Cited by 35 publications
(41 citation statements)
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“…A common site of AD lesions in children is the perioral region. Zheng et al showed that the affected skin is richest in Firmicutes phylum, followed by Proteobacteria , Actinobacteria, and Bacteroidetes phyla [ 56 ]. The dominant species on the skin of the perioral region of healthy infants include the bacteria of the genus Streptococcus and Rothia , whereas in children with AD the abundance of the Staphylococcus genus is increased and the Corynebacterium genus is reduced.…”
Section: The Skin Microbiome In Patients With Atopic Dermatitismentioning
confidence: 99%
See 1 more Smart Citation
“…A common site of AD lesions in children is the perioral region. Zheng et al showed that the affected skin is richest in Firmicutes phylum, followed by Proteobacteria , Actinobacteria, and Bacteroidetes phyla [ 56 ]. The dominant species on the skin of the perioral region of healthy infants include the bacteria of the genus Streptococcus and Rothia , whereas in children with AD the abundance of the Staphylococcus genus is increased and the Corynebacterium genus is reduced.…”
Section: The Skin Microbiome In Patients With Atopic Dermatitismentioning
confidence: 99%
“…The dominant species on the skin of the perioral region of healthy infants include the bacteria of the genus Streptococcus and Rothia , whereas in children with AD the abundance of the Staphylococcus genus is increased and the Corynebacterium genus is reduced. Moreover, the severity of AD positively correlates with decreased Bateroidetes and Fusobacteria phyla [ 56 ]. Further research of AD skin microbiome composition and its functionality will affect treatment options and strategies.…”
Section: The Skin Microbiome In Patients With Atopic Dermatitismentioning
confidence: 99%
“…The PCR system refers to our previously published literature. [18] Purified amplicons were pooled in equimolar quantities and paired-end-sequenced (2 × 300) on an Illumina MiSeq platform (Illumina) according to the standard protocols by Majorbio Bio-Pharm Technology Co. Ltd.…”
Section: Miseq Sequencingmentioning
confidence: 99%
“…The method of sequencing data processing is based on our previously published literature. [18] Operational taxonomic units (OTUs) were clustered with 97% similarity cut-off using UPARSE (version 7.1 http://drive5.com/upars e/), and chimeric sequences were identified and removed using UCHIME. The taxonomy of each 16S rRNA gene sequence was analysed by RDP Classifier algorithm (http://rdp.…”
Section: Processing Of Sequencing Datamentioning
confidence: 99%
“…Many of these taxa were also found to be present when DGGE gel bands were sequenced and data was analyzed by EZTaxon. Some of the taxa found in LS like Acinetobacter 36 , Bacillus 37 , Kocuria 38 , Legionella 39 , Limnobacter 40 , and Paracoccus 41 are reported in human skin infections while some taxa like Gaiella, Pseudonocardia and Sphinobium are not reported to be present with human skin or involved in any human infections.…”
Section: Discussionmentioning
confidence: 99%