Alterations of circulating B cells and follicular helper T cell subsets with low Ig M level in active non-segmental vitiligo

Abstract

Although vitiligo is a multifactorial skin disease, accumulating data have strongly indicated that melanocytes are ultimately destroyed by a cascade of autoimmune responses. Contrast to widely accepted T cell-based cellular immunity, the role of B cell-based humoral immunity in vitiligo remains elusive. The present study investigated the changes of distributions and fucntions of circulating B cells and Tfh cells in patients with active non-segmental vitiligo. Compared with HC, the antibody