Alterations of Hematological Parameters, Hemoglobin and Hematocrit With Liver Enzymes, Aspartate Transaminase and Alanine Transaminase Among Patients With Chronic Kidney Disease Undergoing Hemodialysis in Aljouf Region, Saudi Arabia

Khan, Mohammad Najmuddin; Elderdery, Abozer Y.

doi:10.14740/jh367w

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…This may be one of the potential mechanisms by which anemia or an obvious decrease in serum hemoglobin is prevalent in PLWHA. Another study suggested that anemia may have resulted from insufficient production of erythropoiesis-stimulant erythropoietin in the kidney ( 26 ). Subsequently, it is noteworthy that ferritin is an important iron-containing protein ( 27 ).…”

Section: Discussionmentioning

confidence: 99%

Anemia is independently associated with mortality in people living with human immunodeficiency virus/acquired immune deficiency syndrome: A propensity score matching-based retrospective cohort study in China

Jin

Wang²,

Li³

et al. 2023

Front. Med.

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Although previous studies have suggested that hemoglobin is related to the health status of people living with human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) (PLWHA), the role of anemia in mortality remains unclear. This study aimed to comprehensively quantify the effect of anemia on the mortality risk of PLWHA. In this retrospective cohort study, we thoroughly estimated the effect of anemia on PLWHA mortality, using data collected from January 2005 to June 2022 in the Huzhou area, in 450 subjects extracted from the database of the China Disease Prevention and Control Information System and matched them using a propensity score matching approach to balance potential confounding bias. The potential exposure–response relationship between anemia, hemoglobin concentration, and the mortality of PLWHA was also carefully estimated. A series of subgroup analyses, including interaction analysis, was further conducted to validate the robustness of the effect of anemia on PLWHA death risk. Anemia was significantly associated with an elevated death risk in PLWHA, with an increase of 74% (adjusted hazard ratio [AHR]: 1.74; 95% confidence interval [CI]: 1.03–2.93; p = 0.038) in those with anemia after adjusting for potential confounders. PLWHA with moderate or severe anemia had a higher risk of death, with an 86% increase (AHR = 1.86; 95% CI: 1.01–3.42; p = 0.045). Meanwhile, the AHR tended to increase by 85% on average (AHR = 1.85, 95% CI: 1.37–2.50; p < 0.001) with a per standard deviation (SD) decrease in plasma hemoglobin. Consistent relationships between plasma hemoglobin and the risk of death were further observed in the results from multiple quantile regression models, restricted cubic spline regression models, and a series of subgroup analyses. Anemia is an independent risk factor for HIV/AIDS-related mortality. Our findings may provide new insights into the relevance of PLWHA administration to public health policy, which demonstrate that this low-cost and routinely measured marker (hemoglobin) can be a marker of poor prognosis even before the start of HAART.

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Section: Discussionmentioning

confidence: 99%

Anemia is independently associated with mortality in people living with human immunodeficiency virus/acquired immune deficiency syndrome: A propensity score matching-based retrospective cohort study in China

Jin

Wang²,

Li³

et al. 2023

Front. Med.

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“…However, values of transaminase are lower in cases with chronic renal failure (CRF) whether or not they are dialysis-dependent [34]. This is attributed to several reasons among which is hemodilution, insufficiency in many cofactors in CKD patients such as, vitamin B6, pyridoxine, NADPH, and the presence of uremic factors that inhibit transaminase activity [35,36].…”

Section: Discussionmentioning

confidence: 99%

Occult Hepatitis B Virus Infection Among Patients Undergoing Chronic Dialysis in Hodeidah City, Yemen

El-Morsy

Alghalibi

Elbialy

et al. 2021

Alfarama Journal of Basic & Applied Sciences

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Hepatitis B virus (HBV) is a global major health concern. While Chronic HBV can lead to several severe liver diseases, occult HBV is capable of transmitting infection in hemodialysis units. Since there is lack of information on the pervasiveness of occult HBV in patients regularly receiving hemodialysis in Yemen, this study was designed to fill in this information gap. The study included 150 patients (9 to 75 years), receiving hemodialysis at regular basis. Sera samples were gathered ahead of the hemodialysis session, liver enzymes assessed using commercially available kits, and Hepatitis B surface antigen (HBsAg) as well as other serological markers of HBV measured using commercial enzyme-linked immunosorbent assay (ELISA) kits and rapid cards. HBsAg-negative samples were tested for HBV DNA using SYBR GREEN quantitative polymerase chain reaction (qPCR). All data were statistically analyzed. The prevalence of positive HBsAg was 42.67%, mostly represented by males. No significant relationship existed between the presence of HBsAg and the levels of liver enzymes. Anti-HBs and anti-HBc were detected in 96.5 and 80.2% of patients, respectively. SYBR green qPCR revealed that OBI was detected in ~78% of HBsAg-negative patients which is considered remarkably high. 79% of OBI patients were seropositive whereas only 3% were seronegative. OBI appears to be a significant health issue in hemodialysis patients in Hodeidah city, Yemen. To prevent OBI transmission, the screening of anti-HBc followed by HBV DNA detection in all patients undergoing hemodialysis should be applied. Moreover, hemodialysis patients negative for HBsAg are recommended to be vaccinated for HBV.

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Comparative versatility and diverse biological applications of eco-friendly zinc oxide and cobalt oxide nanoparticles using Punica granatum L. peel extract

Saleh,

Hussein,

Ray

et al. 2024

Nano-Structures & Nano-Objects

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Alterations of Hematological Parameters, Hemoglobin and Hematocrit With Liver Enzymes, Aspartate Transaminase and Alanine Transaminase Among Patients With Chronic Kidney Disease Undergoing Hemodialysis in Aljouf Region, Saudi Arabia

Cited by 4 publications

References 17 publications

Anemia is independently associated with mortality in people living with human immunodeficiency virus/acquired immune deficiency syndrome: A propensity score matching-based retrospective cohort study in China

Anemia is independently associated with mortality in people living with human immunodeficiency virus/acquired immune deficiency syndrome: A propensity score matching-based retrospective cohort study in China

Occult Hepatitis B Virus Infection Among Patients Undergoing Chronic Dialysis in Hodeidah City, Yemen

Comparative versatility and diverse biological applications of eco-friendly zinc oxide and cobalt oxide nanoparticles using Punica granatum L. peel extract

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