Alterations of human erythrocyte membrane fluidity by oxygen-derived free radicals and calcium

Watanabe, Hiroshi; Kobayashi, Akira; Yamamoto, Tadahiro; Suzuki, Shingo; Hayashi, Hideharu; Yamazaki, Noboru

doi:10.1016/0891-5849(90)90150-h

Cited by 110 publications

(61 citation statements)

References 19 publications

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“…10). Despite that the literature data indicate that an LPO intensification results in a decrease of the S value, [58,59,61,62] from our point of view, these changes could not be explained solely by oxidative processes. Thus, the data disclosed above reveal that the cigarette smoke significantly modifies the different regions of liposomes and these modifications are not merely of oxidative origin.…”

Section: Discussioncontrasting

confidence: 46%

“…There exists only a few reports on cell membranes and liposomes exposed to cigarette smoke. [58,59] In the present study, we harnessed liposomes with a relatively low degree of total unsaturation (2.25 mmol mg PC À1 ), which distinguishes them from those used previously. The DB content is one of the characteristic features of lipid substrates, which is of prime interest for the assessment of oxidative stress status.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Different Phases of Cigarette Smoke on Lipid Peroxidation and Membrane Structure in Liposomes

et al. 2014

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This paper discloses for the first time the effects of the gas phase (GP) and the tar of cigarette smoke on lipid peroxidation (LPO) and on the structure of different lipid regions in liposomes. The LPO development was analysed in terms of the total unsaturation of lipids (double-bond, DB, content) and the formation of dienic conjugates (DC), ketodienes (KD), and malonic dialdehyde (MDA). As expected, the exposure of liposomes to either the GP or the tar led to a significant decrease in the DB content. However, the formation of oxidation products revealed different dynamics: MDA generation was inhibited, while the formation of DC and KD increased during the first few hours of the LPO development followed by its inhibition. The smoke constituents exhibited opposite effects on the structure of the lipid bilayer of liposomes: the GP markedly enhanced the microviscosity of liposomal membranes, whereas the tar caused a drastic lowering of microviscosity.

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Section: Discussioncontrasting

confidence: 46%

Section: Discussionmentioning

confidence: 99%

Effects of Different Phases of Cigarette Smoke on Lipid Peroxidation and Membrane Structure in Liposomes

et al. 2014

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“…In addition to the chemical composition, another factor can strongly influence membrane microviscosity, namely, lipid domain peroxidation (22)(23)(24)(25)(26), and this has been the subject of several studies using FR animals.…”

Section: Studies On Membrane Microviscositymentioning

confidence: 99%

“…However, this should result in the precocious aging of animals on restricted diets, which would go against the known "anti-aging" effect of FR. Moreover, because lipid peroxidation is known as one of the major events influencing membrane microviscosity (22)(23)(24)(25)(26), the peroxidizability of cellular membranes was also investigated by using either classical methods or with the aid of a new physiological model, the measurement of mitochondrial membrane potential. The present paper presents a critical review of current problems with membrane microviscosity and lipid peroxidation in FR animals.…”

Section: Introductionmentioning

confidence: 99%

Membrane properties and lipid peroxidation in food restricted animals

Pieri

1997

AGE

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Food restriction (FR) is a well-recognized method of extending mean and maximum longevity of rodents, but the mode of its action remains to be uncovered. This article reviews the effect of FR on the physicalchemical properties and lipid peroxidizability of cellular membranes. FR prevents the age-dependent increase in microviscosity and peroxidizability of cellular membranes. It has been suggested that a decrease in the body temperature occurring in undernourished animals may play a fundamental role in the process. Indeed, the lowering of average body temperature occurring in FR animals may induce a modification in membrane lipid composition, stimulating the cells to counteract the rigidifying effect of lower temperature. Thus, membranes are maintained in a proper functional state by a mechanism similar to that found in poikilotherm animals.

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“…ONOO is a potent initiator of membrane lipid peroxidation (Hogg et al, 1999) and it was reported earlier that IR-associated lipid peroxidation decreases membrane fluidity in various tissues (Dobretsov et al, 1977) and in erythrocytes as well (Watanabe et al, 1990). Based on this background, we evaluated RBC velocity as a measure of perfusion in the serosal microvessels, and direct intravital data were obtained on the deranged intestinal microcirculation.…”

Section: The Direct Action Of Ch 4 On Erythrocyte Deformabilitymentioning

confidence: 99%

Methane bioactivity and interactions with other biological gases

Mészáros

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Alterations of human erythrocyte membrane fluidity by oxygen-derived free radicals and calcium

Cited by 110 publications

References 19 publications

Effects of Different Phases of Cigarette Smoke on Lipid Peroxidation and Membrane Structure in Liposomes

Effects of Different Phases of Cigarette Smoke on Lipid Peroxidation and Membrane Structure in Liposomes

Membrane properties and lipid peroxidation in food restricted animals

Methane bioactivity and interactions with other biological gases

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