Alterations of prostate biomarker expression and testosterone utilization in human LNCaP prostatic carcinoma cells by garlic-derived S-allylmercaptocysteine

Chemistry and Bioactivity of Essential Oils

“…[308,309] and to a lesser extent phenylpropanoids such as myristicin [310] or oils rich in them [89,92] have also been investigated for their anticancer properties [311]. The anticancer properties of thiosulfinates are thought to be mediated by a number of mechanisms, including stimulation of the important hepatic detoxifying glutathione transferase enzymes, downregulation of cancer-promoting enzymes [312,313], inhibition of proliferation [308,314] and induction of apoptosis [315,316].…”

Anticancer Activity of S-Allylmercapto-L-cysteine on Implanted Tumor of Human Gastric Cancer Cell

“…30) SAMC also reportedly inhibits growth and induces apoptosis in SW480 and HT 29 human colon cancer cells, 32) and prostate cancer cells. 33) This anticancer activity of SAMC in vitro [30][31][32][33][34] might be related to the induction of tumor cell apoptosis.…”

“…In addition, SAMC reportedly inhibits growth and induces apoptosis in SW480 and HT 29 human colon cancer cells 32) and prostate cancer cells. 33) Our group also reported that SAMC induces apoptosis in primary gastric cancer cells. 34) SAMC exhibits apoptotic effects through down-regulation of bcl-2/bax proteins and activation of caspase-3 in the gastric cancer cell line.…”

Organosulfur compounds and possible mechanism of garlic in cancer

“…Sliced raw garlic stored in 15-20% ethanol for 20 months is refereed to as AGE. The AGE garlic acts on several fronts in blocking prostate cancer growth; inhibiting polyamines needed for cell division, increasing breakdown of testosterone, that is needed for prostate cancer growth and reducing prostate specific antigen (PSA) levels, a prostate cancer marker (Pinto et al, 1997(Pinto et al, , 2000. Other studies showed that S-allyl mercaptocysteine stops the growth of breast cancer cells, erythroleukemia (Sigounas et al, 1997) and colon cancer cells (Xiao et al, 2003).…”