“…More interestingly, several MS fatigue networks have been described: the fronto-striatal network [157,179,209], the parieto-striatal network [37], the cortico-cortical network mainly involving fronto-frontal and fronto-parietal regions [13,157,169,202,221] and an interhemispheric network consisting of the corpus callosum and its radiating fibers [13,75,178,244,245]. All of them take part in the socalled ''cortico-striato-thalamo-cortical loop'' of MS fatigue [13,22,47,48,54,57,58,70,169,176,177]. Fig.…”