Altered biochemical metabolism and its lateralization in the cortico-striato-cerebellar circuit of unmedicated bipolar II depression

Lai, Shunkai; Zhong, Shuming; Shan, Yanyan; Wang, Ying; Chen, Guanmao; Luo, Xiaomei; Chen, Feng; Zhang, Yiliang; Shen, Shiyi; Huang, Hui; Ning, Yuping; Jia, Yanbin

doi:10.1016/j.jad.2019.07.021

Cited by 18 publications

(8 citation statements)

References 79 publications

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“…Furthermore, patients with schizophrenia displayed more reduced grey matter volume in the insula than patients with bipolar disorder. Several studies have found reduced cerebral blood flow, 50,51 metabolism, [52][53][54] functional activation [55][56][57] and connectivity 58,59 in the insula in patients with schizophrenia and bipolar disorder. Previous meta-analysis of voxel-based morphometry studies have identified grey matter volume reductions in the bilateral insula in patients with schizophrenia 31,60 and bipolar disorder.…”

Section: Discussionmentioning

confidence: 99%

Common and specific patterns of functional and structural brain alterations in schizophrenia and bipolar disorder: a multimodal voxel-based meta-analysis

Wang

Gong

et al. 2022

jpn

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Background: Schizophrenia and bipolar disorder have been linked to alterations in the functional activity and grey matter volume of some brain areas, reflected in impaired regional homogeneity and aberrant voxel-based morphometry. However, because of variable findings and methods used across studies, identifying patterns of brain alteration in schizophrenia and bipolar disorder has been difficult. Methods: We conducted a meta-analysis of differences in regional homogeneity and voxel-based morphometry between patients and healthy controls for schizophrenia and bipolar disorder separately, using seed-based d mapping. Results: We included 45 publications on regional homogeneity (26 in schizophrenia and 19 in bipolar disorder) and 190 publications on voxel-based morphometry (120 in schizophrenia and 70 in bipolar disorder). Patients with schizophrenia showed increased regional homogeneity in the frontal cortex and striatum and the supplementary motor area; they showed decreased regional homogeneity in the insula, primary sensory cortex (visual and auditory cortices) and sensorimotor cortex. Patients with bipolar disorder showed increased regional homogeneity in the frontal cortex and striatum; they showed decreased regional homogeneity in the insula. Patients with schizophrenia showed decreased grey matter volume in the superior temporal gyrus, inferior frontal gyrus, cingulate cortex and cerebellum. Patients with bipolar disorder showed decreased grey matter volume in the insula, cingulate cortex, frontal cortex and thalamus. Overlap analysis showed that patients with schizophrenia displayed decreased regional homogeneity and grey matter volume in the left insula and left superior temporal gyrus; patients with bipolar disorder displayed decreased regional homogeneity and grey matter volume in the left insula. Limitations: The small sample size for our subgroup analysis (unmedicated versus medicated patients and substantial heterogeneity in the results for some regions could limit the interpretability and generalizability of the results. Conclusion: Patients with schizophrenia and bipolar disorder shared a common pattern of regional functional and structural alterations in the insula and frontal cortex. Patients with schizophrenia showed more widespread functional and structural impairment, most prominently in the primary sensory motor areas.

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Section: Discussionmentioning

confidence: 99%

Common and specific patterns of functional and structural brain alterations in schizophrenia and bipolar disorder: a multimodal voxel-based meta-analysis

Wang

Gong

et al. 2022

jpn

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“…The search identified 33 studies [ 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 ] ( Figure 1 ), which included a total of 800 HCs and 873 BD patients. Among these 33 studies, 11 studies included patients in a major depressive episode (238 patients), 21 studies included BD patients in clinical remission (603 patients), and one study combined BD patients in a major depressive episode and in clinical remission (22 patients in each group).…”

Section: Resultsmentioning

confidence: 99%

“… Studies Standardized Mean Differences (SMDs) of N-acetylaspartate differences between bipolar patients and controls in the left white matter prefrontal cortex [ 44 , 46 , 47 , 61 , 62 ]. …”

Section: Figurementioning

confidence: 99%

Glutamatergic and N-Acetylaspartate Metabolites in Bipolar Disorder: A Systematic Review and Meta-Analysis of Proton Magnetic Resonance Spectroscopy Studies

Chabert

Allauze

Pereira

et al. 2022

IJMS

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The exact neurobiological mechanisms of bipolar disorder (BD) remain unknown. However, some neurometabolites could be implicated, including Glutamate (Glu), Glutamine (Gln), Glx, and N-acetylaspartate (NAA). Proton Magnetic Resonance Spectroscopy (1H-MRS) allows one to quantify these metabolites in the human brain. Thus, we conducted a systematic review and meta-analysis of the literature to compare their levels between BD patients and healthy controls (HC). The main inclusion criteria for inclusion were 1H-MRS studies comparing levels of Glu, Gln, Glx, and NAA in the prefrontal cortex (PFC), anterior cingulate cortex (ACC), and hippocampi between patients with BD in clinical remission or a major depressive episode and HC. Thirty-three studies were included. NAA levels were significantly lower in the left white matter PFC (wmPFC) of depressive and remitted BD patients compared to controls and were also significantly higher in the left dorsolateral PFC (dlPFC) of depressive BD patients compared to HC. Gln levels were significantly higher in the ACC of remitted BD patients compared to in HC. The decreased levels of NAA of BD patients may be related to the alterations in neuroplasticity and synaptic plasticity found in BD patients and may explain the deep white matter hyperintensities frequently observed via magnetic resonance imagery.

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“…Dysfunction in these brain areas has been linked to depressive symptoms, and traditionally, studies [23] have paid close attention to the frontal-limbic network. The most recent evolution of the frontal-striatal-cerebellar circuit model has gained increasing attention, and this model emphasizes that the posterior cerebellum lobe, anterior cingulate cortex and ventromedial prefrontal cortex, as vital components of this circuit might be associated with depression-related functional impairments, such as problem solving, decision making, self-referential problems and negative ruminations [22,24]. Studies [24][25][26] using electroencephalography (EEG), magnetoencephalography (MEG), positron emission tomography (PET), singlephoton emission computed tomography (SPECT), magnetic resonance spectroscopy (MRS), structural and functional magnetic resonance imaging have demonstrated that abnormalities in frontal-striatal-cerebellar circuits are associated with major depressive disorder, ET with depression, PD with depression and other chronic diseases with depression, such as chronic pain with depression.…”

Section: Depression Can Be a Primary Phenomenon In Etmentioning

confidence: 99%

Altered local and matrix functional connectivity in depressed essential tremor patients

Duan

Zhou

et al. 2021

BMC Neurol

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Background Depression in essential tremor (ET) has been constantly studied and reported, while the associated brain activity changes remain unclear. Recently, regional homogeneity (ReHo), a voxel-wise local functional connectivity (FC) analysis of resting-state functional magnetic resonance imaging, has provided a promising way to observe spontaneous brain activity. Methods Local FC analyses were performed in forty-one depressed ET patients, 49 non-depressed ET patients and 43 healthy controls (HCs), and then matrix FC and clinical depression severity correlation analyses were further performed to reveal spontaneous neural activity changes in depressed ET patients. Results Compared with the non-depressed ET patients, the depressed ET patients showed decreased ReHo in the bilateral cerebellum lobules IX, and increased ReHo in the bilateral anterior cingulate cortices and middle prefrontal cortices. Twenty-five significant changes of ReHo clusters were observed in the depressed ET patients compared with the HCs, and matrix FC analysis further revealed that inter-ROI FC differences were also observed in the frontal-cerebellar-anterior cingulate cortex pathway. Correlation analyses showed that clinical depression severity was positively correlated with the inter-ROI FC values between the anterior cingulate cortex and bilateral middle prefrontal cortices and was negatively correlated with the inter-ROI FC values of the anterior cingulate cortex and bilateral cerebellum lobules IX. Conclusion Our findings revealed local and inter-ROI FC differences in frontal-cerebellar-anterior cingulate cortex circuits in depressed ET patients, and among these regions, the cerebellum lobules IX, middle prefrontal cortices and anterior cingulate cortices could function as pathogenic structures underlying depression in ET patients.

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Altered biochemical metabolism and its lateralization in the cortico-striato-cerebellar circuit of unmedicated bipolar II depression

Cited by 18 publications

References 79 publications

Common and specific patterns of functional and structural brain alterations in schizophrenia and bipolar disorder: a multimodal voxel-based meta-analysis

Common and specific patterns of functional and structural brain alterations in schizophrenia and bipolar disorder: a multimodal voxel-based meta-analysis

Glutamatergic and N-Acetylaspartate Metabolites in Bipolar Disorder: A Systematic Review and Meta-Analysis of Proton Magnetic Resonance Spectroscopy Studies

Altered local and matrix functional connectivity in depressed essential tremor patients

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