Altered cell mediated immunity in atrophic rhinitis

Fouad, H M A; Afifi, Noha M.; Fatt-Hi, A.; El-Sheemy, N.; Iskander, Iman; Saif, Mofid

doi:10.1017/s0022215100089180

Cited by 15 publications

(6 citation statements)

References 13 publications

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“…The leucocyte migration test and spontaneous rosette test were performed in vitro to assess the cellular immunity status of patients with AR. 34 With the leucocyte migration test, the mean migration percentage in patients with AR was lower than in the control group indicating recognition of the antigen by circulating leucocytes. In the spontaneous rosette test, patients with AR did not form or formed poorly a rosette compared to the control group.…”

Section: Immunologymentioning

confidence: 87%

“…Type I allergy was evident in 85 per cent of Thai patients with AR in a recent study. 11 Another study evaluated cellular immunity in patients with AR using the leucocyte migration and spontaneous rosette test in vitro; 34 this confirmed altered cellular reactivity or loss of tolerance to nasal tissues. Various factors such as viral infections, malnutrition and immunodeficiency may trigger a destructive autoimmune process with the release of antigens of nasal mucosa into the circulation.…”

Section: Primary Atrophic Rhinitismentioning

confidence: 95%

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The aetiology and management of atrophic rhinitis

Dutt

Kameswaran

2005

J. Laryngol. Otol.

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Atrophic rhinitis is a chronic, debilitating and recalcitrant disease of the nasal cavities that is prevalent in several parts of the world. It has unique epidemiological features and clinical characteristics. Clinicians and researchers for decades have tried to postulate theories for the aetiology of the primary form of the disease. Management of the disease has seen several medical therapeutic regimens including alternative forms of medicine. Surgical options for the condition are also not completely satisfactory with a number of failures and recurrences. The authors provide here a comprehensive review of the existing literature as regards the aetiology and management of this refractory condition.

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Section: Immunologymentioning

confidence: 87%

Section: Primary Atrophic Rhinitismentioning

confidence: 95%

The aetiology and management of atrophic rhinitis

Dutt

Kameswaran

2005

J. Laryngol. Otol.

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“…A destructive autoimmune process had been postulated by Fouad et.al. 8 as a cause for primary atrophic rhinitis. Dobbie et al 20 detected antibodies raised against surfactant protein-A, exhibit a ranking of tissue reactivity in area, intensity and density of cells that also paralleled the frequency and degree of pathological involvement characteristic of rheumatoid disease.…”

Section: Discussionmentioning

confidence: 99%

“…Sympathectomy in atrophic rhinitis has been followed by a temporary improvement. (6) Auto-immune theory: Fouad et al 8 concluded that viral infection, malnutrition and/or immunode ciency might trigger a destructive auto-immune process with the release of antigen(s) of nasal mucosa into the circulation.…”

Section: Introductionmentioning

confidence: 99%

Study of surfactant level in cases of primary atrophic rhinitis

Sayed

Abou-Elhamd²,

Abdel‐Kader³

et al. 2000

J. Laryngol. Otol.

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The surfactant system of the nose was examined biochemically in control cases and compared to cases of primary atrophic rhinitis. The study group included 25 cases with primary atrophic rhinitis compared to 10 normal volunteers. Biochemical analysis of the nasal aspirate in these cases revealed the presence of phospholipids constituting surfactant with phosphatidylcholine constituting 75.35 per cent of the total phospholipids. Biochemical analysis of the nasal aspirate in cases with primary atrophic rhinitis revealed a significant decrease in the total phospholipids compared to normal cases and also a significant change in the phospholipid profile. Thus significant biochemical changes in the surfactant system of the nose is an evident and early finding in cases of primary atrophic rhinitis. This suggests a possible role for surfactant deficiency in the aetiopathogenesis of cases of primary atrophic rhinitis.

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“…The fundamental pathogenesis of this condition remains obscure. Beside the abnormal turbulence of air flow in the nasal fossae, causes such as climate and racial factors, 1 ciliostasis provoked by superinfection, 2 autoimmune mechanisms, 3 and reflex sympathetic dystrophy 4,5 have all been suggested. The clinical picture is dominated by progressive atrophy of the nasal and turbinate mucosa, as well as the resorption of the underlying bone, which can sometimes be considerable 6 …”

Section: Introductionmentioning

confidence: 99%

Triosite Implants and Fibrin Glue in the Treatment of Atrophic Rhinitis: Technique and Results

Bertrand¹,

Doyen²,

Eloy³

1996

The Laryngoscope

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Nine patients with primary or secondary atrophic rhinitis were treated by narrowing of the nasal fossae using a new surgical technique (derived from the Eryes procedure) in which a Triosite and fibrin glue mixture is implanted via the labial vestibule route. The results were good or excellent in seven patients. No rejections occurred. Osseocoalescence, as evaluated by computed axial tomography at 6 months, was good. Inspiratory intrasnasal pain in patients with postsurgical atrophic rhinitis improved following the operation. The surgical technique, which is quick and easy to perform, avoids the discomfort of nostril closure or the implantation of grafts from other parts of the body. Complicated flap procedures are also avoided.

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Altered cell mediated immunity in atrophic rhinitis

Cited by 15 publications

References 13 publications

The aetiology and management of atrophic rhinitis

The aetiology and management of atrophic rhinitis

Study of surfactant level in cases of primary atrophic rhinitis

Triosite Implants and Fibrin Glue in the Treatment of Atrophic Rhinitis: Technique and Results

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