Altered cellular immune response following peer separation

Reite, Martin; Harbeck, Ronald J.; Hoffman, Andree A.

doi:10.1016/0024-3205(81)90201-0

Cited by 87 publications

(28 citation statements)

References 9 publications

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“…Even small alterations in species-typical rearing conditions were observed to have adverse long-term impacts on stress physiology and emotionality among nonhuman primates (Gunnar & Quevedo, 2007;Sanchez, 2006 (Levine & Wiener, 1988), ACTH (Clarke & Boinski, 1995), norepinephrine (Higley, Hasert, Suomi, & Linnoila, 1991), and immune response (Boccia, Laudenslager, & Reite, 1995;Coe, 1993;Gorman, Mathew, & Coplan, 2002;Reite, Harbeck, and Hoffman, 1981). Environmental conditions also impact stress physiology.…”

Section: Allostatic Load During Growth a N D De V E L O P Me N Tmentioning

confidence: 99%

Allostatic load and biological anthropology

Edes

Crews

2017

American J Phys Anthropol

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Multiple stressors affect developing and adult organisms, thereby partly structuring their phenotypes. Determining how stressors influence health, well-being, and longevity in human and nonhuman primate populations are major foci within biological anthropology. Although much effort has been devoted to examining responses to multiple environmental and sociocultural stressors, no holistic metric to measure stress-related physiological dysfunction has been widely applied within biological anthropology. Researchers from disciplines outside anthropology are using allostatic load indices (ALIs) to estimate such dysregulation and examine life-long outcomes of stressor exposures, including morbidity and mortality. Following allostasis theory, allostatic load represents accumulated physiological and somatic damage secondary to stressors and senescent processes experienced over the lifespan. ALIs estimate this wear-and-tear using a composite of biomarkers representing neuroendocrine, cardiovascular, metabolic, and immune systems. Across samples, ALIs are associated significantly with multiple individual characteristics (e.g., age, sex, education, DNA variation) of interest within biological anthropology. They also predict future outcomes, including aspects of life history variation (e.g., survival, lifespan), mental and physical health, morbidity and mortality, and likely health disparities between groups, by stressor exposures, ethnicity, occupations, and degree of departure from local indigenous life ways and integration into external and commodified ones. ALIs also may be applied to similar stress-related research areas among nonhuman primates. Given the reports from multiple research endeavors, here we propose ALIs may be useful for assessing stressors, stress responses, and stress-related dysfunction, current and long-term cognitive function, health and well-being, and risk of early mortality across many research programs within biological anthropology. K E Y W O R D Saging, allostasis, frailty, growth and development, nonhuman primates, senescence, stress | I N T R O D U C T I O NTraditional research foci within biological anthropology include variations in stress, morbidity, and mortality (for reviews, see Ice & James, 2007;Little, 2010). Despite this long-term focus, the field continues to pursue a reliable, relatively easy to apply metric for assessing lifetime stress and stress-related outcomes. We suggest incorporating the theory of allostasis and methods for assessing allostatic load within anthropological theory and methodology to aid in closing this gap. As a theory, allostasis was developed to explain how mammalian physiological responses to stressors in their environments evolved to maximize the probability of survival while limiting somatic damage (Korte, Koolhaas, Wingfield, & McEwen, 2005;McEwen & Stellar, 1993;McEwen & Wingfield, 2003;Sterling, 2004Sterling, , 2012Sterling & Eyer, 1988). Unfortunately, such beneficial defensive responses come at a cost and, over time, repeated allostatic activi...

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Section: Allostatic Load During Growth a N D De V E L O P Me N Tmentioning

confidence: 99%

Allostatic load and biological anthropology

Edes

Crews

2017

American J Phys Anthropol

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“…Between 5 and 7 months of age, four of the nine group-reared monkeys underwent a 10-day period of maternal separation. The remaining five group-reared monkeys served as nonseparated controls (see details in REITE et al, 1981). The remaining two monkeys, born within a day of each other, were removed from their mothers within 3 days of birth and reared together as peers.…”

Section: Subjectsmentioning

confidence: 99%

The roles of early separation experience and prior familiarity in the social relations of pigtail macaques: A descriptive multivariate study

Capitanio

Reite

1984

Primates

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ABSTRACT. Research has suggested that a social separation during a macaque's infancy may result in later deficiencies in maternal behavior, as well as in reduced sociability. The present study examined whether monkeys now living in an all-peer group who had experienced a maternal separation 1.5 to 3 years prior to the time of these observations, displayed persisting social deficits. Using multivariate techniques, prior separation history, as well as several demographic variables were examined as to their role in explaining the observed variation in measures of social behavior and preference. The results indicated that, as compared to nonseparated controls, previously separated monkeys played less, displayed social preferences to fewer animals, displayed fewer contact preferences, and showed reciprocated preferences to fewer individuals. In addition, several gender and rank-related effects were found. In terms of the identities of the preferred partners, individuals preferred animals from the same natal group. The results support the notion that an early separation experience can result in long-term social impairment, although the effects appear to be subtle.

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“…185th, Beaverton, Oregon 97006. Reite et al, 1974Reite et al, , 1981Boccia et al, 1989;Laudenslager et al, 1990;Weeks et al, 1989;Gunderson et al, 1987Gunderson et al, , 1989Clarren et al, 1990Clarren et al, , 1992Morton et al, 1993].…”

Section: Introductionmentioning

confidence: 99%