Altered Cerebellar Resting-State Functional Connectivity in Early-Stage Parkinson's Disease Patients With Cognitive Impairment

Dan, Xiaojuan; Hu, Yang; Sun, Junyan; Gao, Linlin; Zhou, Yanjun; Ma, Jinghong; Doyon, Julien; Wu, Tao; Chan, Piu

doi:10.3389/fneur.2021.678013

Cited by 5 publications

(2 citation statements)

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“…There are many examples of enhancement of preserved functions in the brain upon a static injury or following sensory loss, and such remarkable observations offer a biological plausibility for this framework 16 . Such adaptive neural plasticity likely also exists in the parkinsonian brain, where initially preserved brain areas can take over functions of the damaged nigrostriatal circuitry 5 , 17 , 18 . To grow better beyond a traumatic event is beautifully represented by the Japanese art of Kintsugi, which enhances the beauty of broken objects, repairing them with golden painting and other techniques 19 .…”

Section: Possible Implicationsmentioning

confidence: 99%

The silver linings of Parkinson’s disease

Alonso‐Cánovas

Voeten²,

Thomas³

et al. 2022

npj Parkinsons Dis.

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Parkinson’s disease (PD) is a neurodegenerative condition, characterized by motor, non-motor disability, and a reduced quality of life. Stimulated by a question raised by a person with PD, we posted an orienting survey on social media, asking whether there is possibly any “silver lining” (an upside) to having PD. Most respondents identified one or more positive changes, mainly a new focus in life, better coping skills, new activities, healthier lifestyle, and improved relationships with relatives and friends. This ability to perceive a silver lining of disease is in line with the concept of adversarial growth in illness, and positive health, which underscores resilience, self-management, and the ability to adapt. Importantly, not every respondent identified an upside to living with PD, so this is very much an example of personalized medicine. This is a delicate, difficult issue, and discussing the presence of silver linings may feel counterintuitive. However, exploring this issue may help people with PD and caregivers to better deal with the disease, and allow medical professionals to provide better support, to learn about coping strategies, to understand the degree of disease acceptance, and to enhance a healthier lifestyle. Further research should demonstrate whether addressing silver linings may impact positively on the outcome of PD and on the perceived quality of life. To facilitate this process, we have adapted a pre-existing silver lining questionnaire (SLQ-38) in light of the responses provided by people with PD, to offer a simple, feasible tool to further explore this issue in clinical and research settings.

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Section: Possible Implicationsmentioning

confidence: 99%

The silver linings of Parkinson’s disease

Alonso‐Cánovas

Voeten²,

Thomas³

et al. 2022

npj Parkinsons Dis.

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“…As such, it is often unclear whether the results of these PD studies are due to the disease, medication being used, or a combination of both factors. Moreover, only very few studies reported that altered cerebellar FC and FC between the “motor” cerebellum and SMA was positively correlated with motor scores, while intra-cerebellar connectivity was positively correlated with cognitive scores in PD patients with cognitive impairment ( Dan et al, 2021 ). It becomes important to understand the underlying pathophysiological mechanisms of PD at an early stage and without medication administration.…”

Section: Introductionmentioning

confidence: 99%

Cerebellar functional connectivity change is associated with motor and neuropsychological function in early stage drug-naïve patients with Parkinson’s disease

et al. 2023

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IntroductionParkinson’s Disease (PD) is a progressive neurodegenerative disorder affecting both motor and cognitive function. Previous neuroimaging studies have reported altered functional connectivity (FC) in distributed functional networks. However, most neuroimaging studies focused on patients at an advanced stage and with antiparkinsonian medication. This study aims to conduct a cross-sectional study on cerebellar FC changes in early-stage drug-naïve PD patients and its association with motor and cognitive function.MethodsTwenty-nine early-stage drug-naïve PD patients and 20 healthy controls (HCs) with resting-state fMRI data and motor UPDRS and neuropsychological cognitive data were extracted from the Parkinson’s Progression Markers Initiative (PPMI) archives. We used seed-based resting-state fMRI (rs-fMRI) FC analysis and the cerebellar seeds were defined based on the hierarchical parcellation of the cerebellum (AAL atlas) and its topological function mapping (motor cerebellum and non-motor cerebellum).ResultsThe early stage drug-naïve PD patients had significant differences in cerebellar FC when compared with HCs. Our findings include: (1) Increased intra-cerebellar FC within motor cerebellum, (2) increase motor cerebellar FC in inferior temporal gyrus and lateral occipital gyrus within ventral visual pathway and decreased motor-cerebellar FC in cuneus and dorsal posterior precuneus within dorsal visual pathway, (3) increased non-motor cerebellar FC in attention, language, and visual cortical networks, (4) increased vermal FC in somatomotor cortical network, and (5) decreased non-motor and vermal FC within brainstem, thalamus and hippocampus. Enhanced FC within motor cerebellum is positively associated with the MDS-UPDRS motor score and enhanced non-motor FC and vermal FC is negatively associated with cognitive function test scores of SDM and SFT.ConclusionThese findings provide support for the involvement of cerebellum at an early stage and prior to clinical presentation of non-motor features of the disease in PD patients.

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