Altered colonic motility is associated with low anterior resection syndrome, by Keane et al

McDermott, Frank

doi:10.1111/codi.15547

Cited by 2 publications

(2 citation statements)

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“…CRC is the third most common cancer in the world, accounting for more than one third of all cancers, with an age-standardized rate of 7.7 per 100,000, and among them the rectal cancer is accounting for 5% in all cases (1)(2)(3)(4). With the advances in chemotherapy, radiotherapy, and surgical techniques, the long-term survival rate is increasing after CRC surgery regardless of the rising incidences of these diseases (5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

“…Laparoscopic LAR is a technically difficult procedure that involves transection of the intraperitoneal rectum in a limited pelvic cavity, and the undesirable result of this surgery is low anterior resection syndrome (LARS). The prevalence is around 80%–90%, and patients experience LARS with varying degrees of severity after sphincter-preserving LAR surgery ( 1 – 3 , 9 , 12 , 13 ).…”

Section: Introductionmentioning

confidence: 99%

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The risk factors of low anterior resection syndrome after colorectal cancer surgery: A retrospective study of 566 patients in a single institution in China

Kang

et al. 2022

Front. Surg.

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PurposeThis study aims to identify the independent risk factors in the low anterior resection syndrome (LARS) after surgery for colorectal cancer (CRC).MethodThis was a retrospective, single-institution study in the Second Affiliation Hospital of Dalian Medical University, China. Patients underwent sphincter-preserving low anterior resection with total or partial mesorectal resection (with or without protective ileostomy) and completed a self-filled questionnaire over the phone to assess postoperative bowel dysfunction from January 2017 to December 2019. The predictors of LAR were evaluated using univariate and multivariate analyses.ResultThe study population was 566 patients, 264 (46.64%), 224 (39.58%), and 78 (13.78%) patients with no, minor, and major LARS, respectively. In the univariate analysis, independent factors such as tumor location and size, anastomotic height, protective ileostomy, post-operation chemoradiotherapy, tumor T stage, lymphatic nodal metastasis classification, surgery duration, and time interval for closure of stoma were significantly associated with LARS points while we found the tumor T stage and lymphatic nodal metastasis classification as the new independent risk factors compared with the last decade studies. In the multivariate analysis, factors such as low and middle tumor location and protective ileostomy, and post operation treatment, nodal metastasis classification were the independent risk factors for major LARS.ConclusionThe new independence risk factors were tumor T stage and lymphatic nodal metastasis status in univariate analysis in our study, with anastomotic height, low and middle tumor location, protective ileostomy, post-operation chemoradiotherapy, nodal metastasis status increasing LARS point in multivariate analysis after surgery for CRC.

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Section: Introductionmentioning

confidence: 99%