Altered early infant gut microbiota in children developing allergy up to 5 years of age

Abstract

Background: Early colonization with bifidobacteria and lactobacilli is postulated to protect

Microbiota and Allergy: From Dysbiosis to Probiotics

“…Similarly, B. catenulatum/pseudocatenulatum has been isolated from both allergic (Gore et al, 2008) and non-allergic infants (Stsepetova et al, 2007). Some authors report that restricted Bifidobacterium diversity is linked with allergy (Stsepetova et al, 2007) but again, this was not confirmed in other studies at the species (Sjogren et al, 2009;Waligora-Dupriet et al, 2011) or strain level (Waligora-Dupriet et al, 2011). It has been suggested that the intrinsic properties of bacterial strains may be pertinent.…”

“…The authors suggested that place of birth influences the patterns of bifidobacterial species present. B. adolescentis has been found in the fecal microbiota of both allergic infants (Ouwehand et al, 2001;He et al, 2001) and non-allergic infants (Sjogren et al, 2009). Similarly, B. catenulatum/pseudocatenulatum has been isolated from both allergic (Gore et al, 2008) and non-allergic infants (Stsepetova et al, 2007).…”

“…Bacteroidaceae are also associated with allergic development, although, as for clostridia and bifidobacteria, findings are contradictory. Indeed, Bacteroides colonization of the gut was not found to be linked to allergy in several studies (Adlerberth et al, 2007;Kalliomaki et al, 2001a;Bjorksten et al, 2001;Sjogren et al, 2009), but colonization with the B. fragilis group at age 3 weeks has been associated with a higher risk of developing asthma later in life Vael et al, 2011). A high level of Bacteroides colonization positively correlated with IgE in children with atopic dermatitis (Kirjavainen et al, 2002).…”

“…As E. coli was only associated with eczema and C. difficile was associated with all atopic outcomes, the underlying mechanisms may be different. Colonization with clostridia, including C. difficile, was associated with allergy development up to age 2 years in several studies (Kalliomaki et al, 2001a;Bjorksten et al, 2001;Penders et al, 2007) but not in others (Adlerberth et al, 2007;Sjogren et al, 2009;Songjinda et al, 2007). Fecal colonization at age 3 weeks with Clostridium coccoides subcluster XIVa species has been described as an early indicator of possible asthma later in life Vael et al, 2011).…”

Le microbiote intestinal et la digestion des polysaccharides

“…Le déséquilibre du microbiote intestinal pourrait éga-lement être impliqué dans d'autres maladies inflammatoires, comme la rectocolite hémorragique [36], le syndrome de l'intestin irritable [36] et aussi dans des maladies auto-immunes telles que l'allergie [37], et dans les troubles du spectre autistique [38]. La liste des maladies pour lesquelles on implique le microbiote intestinal s'allonge pratiquement tous les jours [44] sans qu'un véritable lien de causalité entre le déséquilibre du microbiote et ces maladies ne soit réellement démontré.…”