Altered EEG lagged coherence during rest in obsessive–compulsive disorder

Olbrich, Sebastian; Olbrich, H. M.; Adamaszek, Michael; Jahn, Ina; Hegerl, Ulrich; Stengler, Katarina

doi:10.1016/j.clinph.2013.05.031

Cited by 32 publications

(19 citation statements)

References 60 publications

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“…Non-instantaneous or lagged coherence is a methodological approach to frequency domain connectivity that removes the effects of volume conduction in EEG co-spectra ( Pascual-Marqui, 2007 ; Pascual-Marqui et al, 2011 ). Lagged coherence has been used to investigate functional connectivity in resting-state brain networks in several disorders, e.g., Olbrich et al (2013) , Mohan et al (2016a) , Schwartz et al (2016) . However, to our knowledge, brain connectivity in AWS has not yet been investigated with lagged coherence.…”

Section: Methodsmentioning

confidence: 99%

Evidence for a Resting State Network Abnormality in Adults Who Stutter

Ghaderi

Andevari

Sowman

2018

Front. Integr. Neurosci.

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Neural network-based investigations of stuttering have begun to provide a possible integrative account for the large number of brain-based anomalies associated with stuttering. Here we used resting-state EEG to investigate functional brain networks in adults who stutter (AWS). Participants were 19 AWS and 52 age-, and gender-matched normally fluent speakers. EEGs were recorded and connectivity matrices were generated by LORETA in the theta (4–8 Hz), alpha (8–12 Hz), beta1 (12–20 Hz), and beta2 (20–30 Hz) bands. Small-world propensity (SWP), shortest path, and clustering coefficients were computed for weighted graphs. Minimum spanning tree analysis was also performed and measures were compared by non-parametric permutation test. The results show that small-world topology was evident in the functional networks of all participants. Three graph indices (diameter, clustering coefficient, and shortest path) exhibited significant differences between groups in the theta band and one [maximum betweenness centrality (BC)] measure was significantly different between groups in the beta2 band. AWS show higher BC than control in right temporal and inferior frontal areas and lower BC in the right primary motor cortex. Abnormal functional networks during rest state suggest an anomaly of DMN activity in AWS. Furthermore, functional segregation/integration deficits in the theta network are evident in AWS. These deficits reinforce the hypothesis that there is a neural basis for abnormal executive function in AWS. Increased beta2 BC in the right speech–motor related areas confirms previous evidence that right audio–speech areas are over-activated in AWS. Decreased beta2 BC in the right primary motor cortex is discussed in relation to abnormal neural mechanisms associated with time perception in AWS.

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Section: Methodsmentioning

confidence: 99%

Evidence for a Resting State Network Abnormality in Adults Who Stutter

Ghaderi

Andevari

Sowman

2018

Front. Integr. Neurosci.

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“…Obsessive-Compulsive Disorder (OCD) is a neuropsychiatric disorder with a lifelong predominance of 2% to 4% which happens at a 1:1 male to female ratio ( Olbrich et al, 2013 ). It is characterized by regressive sudden thoughts (obsessions) and repetitive behaviors.…”

Section: Introductionmentioning

confidence: 99%

Normal Electrical Activity of the Brain in Obsessive-Compulsive Patients After Anodal Stimulation of the Left Dorsolateral Prefrontal Cortex

Ghaffari

Yoonessi

Darvishi

et al. 2018

BCN

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Introduction:Transcranial Direct Current Stimulation (tDCS) has been used as a non-invasive method to increase the plasticity of brain. Growing evidence has shown several brain disorders such as depression, anxiety disorders, and chronic pain syndrome are improved following tDCS. In patients with Obsessive-Compulsive Disorder (OCD), increased brain rhythm activity particularly in the frontal lobe has been reported in several studies using Eectroencephalogram (EEG). To our knowledge, no research has been done on the effects of electrical stimulation on brain signals of patients with OCD. We measured the electrical activity of the brain using EEG in patients with OCD before and after tDCS and compared it to normal participants.Methods:Eight patients with OCD (3 males) and 8 matched healthy controls were recruited. A 64-channel EEG was used to record a 5-min resting state before and after application of tDCS in both groups. The intervention of tDCS was applied for 15 minutes with 2 mA amplitude where anode was placed on the left Dorsolateral Prefrontal Cortex (DLPFC) and cathode on the right DLPFC.Results:In line with previous studies, the results showed that the power of Delta frequency band in OCD patients are significantly higher than the normal group. Following anodal tDCS, hyperactivity in Delta and Theta bands declined in most channels, particularly in DLPFC (F3, F4) and became similar to normal signals pattern. The reduction in Delta band was significantly more than the other bands.Conclusion:Anodal tDCS over the left DLPFC significantly decreased the power of frequency bands of Delta and Theta in Patients with OCD. The pattern of EEG activity after tDCS became particularly similar to normal, so tDCS may have potential clinical application in these patients.

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“…In the same vein, abnormal EEGs have been observed in patients with OCD (Kuskowski et al, 1993;Locatelli, Bellodi, Grassi, & Scarone, 1996;Bucci et al, 2004;Pogarell et al, 2006;Velikova et al, 2010;Koprivova et al, 2011;Koprivova, Horacek, Raszka, Brunovsky, & Prasko, 2013;Olbrich et al, 2013). Resting state EEG source localization studies reported that cingulate gyrus plays an important role in OCD (Koprivova et al, 2011;Sherlin & Congedo, 2005;Velikova et al, 2010).…”

Section: Introductionmentioning

confidence: 73%

The Efficacy of Psychoneurotherapy on Reducing Symptoms Severity in Treatment Naïve Patients With Obsessive-Compulsive Washing

Saremi

Nazari

Shariat

et al. 2016

PCP

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Objective: The present study was carried out to examine the effectiveness of psychoneurotherapy (PNT) on reducing symptoms severity in treatment-naïve patients with obsessive-compulsive washing. This study evaluated a new form of psychotherapy based on neurobiological model of Obsessive-Compulsive Disorder Washing (OCD-W). Methods:The study was conducted as a quasi-experimental research. The statistical population of this study included 130 obsessive-compulsive washers. A total of 40 patients were selected using convenience sampling method and then were randomly divided into two groups: PNT group (n=20) and sham feedback control group (n=20). Both groups received drug treatment, in addition, the experimental group received 20 sessions (twice per week) of PNT. The Yale-Brown obsessive compulsive scale (Y-BOCS), Maudsley obsessional-compulsive inventory (MOCI), depression, anxiety, and stress scale-21 (DASS-21), subjective united distress scale (SUDS) were administered before and after treatment. Eelectroencephography (EEG) was recorded in eyes open provocation stimuli condition. All EEGs were recorded drug free. Participants were prescribed PNT protocol based on the results of their quantitative EEG (QEEG) and low-resolution electromagnetic tomography analyses. The effects of PNT were analyzed using 1-way analysis of covariance (ANCOVA) after controlling pretest scores. The effect size (Cohen's d), paired t test, and clinically significant change were calculated and assessed for all the clinical instruments.Results: Thirty patients completed this study. Despite some methodological limitations, our results indicated that psychoneurotherapy is significantly efficient on treatment's target. ANCOVA results supported that PNT could significantly improve the severity of OCD symptoms, depression, stress, anxiety symptoms, and subjective united distress scale compared to what was seen sham feedback control group (All P<0.001). Conclusion:Psychoneurotherapy showed preliminarily evidence for the effectiveness in the treatment of patients with obsessive-compulsive washing. The study is an attempt to provide a new non-invasive treatment of OCD-washing. Further studies are necessary for confirming our findings.

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Altered EEG lagged coherence during rest in obsessive–compulsive disorder

Cited by 32 publications

References 60 publications

Evidence for a Resting State Network Abnormality in Adults Who Stutter

Evidence for a Resting State Network Abnormality in Adults Who Stutter

Normal Electrical Activity of the Brain in Obsessive-Compulsive Patients After Anodal Stimulation of the Left Dorsolateral Prefrontal Cortex

The Efficacy of Psychoneurotherapy on Reducing Symptoms Severity in Treatment Naïve Patients With Obsessive-Compulsive Washing

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