Altered expression and mutation of β‐catenin gene in gastric carcinomas and cell lines

Woo, Dong Kyun; Kim, Hee Sung; Lee, Hye Seung; Kang, Young Hwa; Yang, Han Kwang; Kim, Woo Ho

doi:10.1002/1097-0215(20010320)95:2<108::aid-ijc1019>3.0.co;2-#

Cited by 138 publications

(92 citation statements)

References 18 publications

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“…Other researchers have documented the presence of CTNNB1 mutations in GC with varying frequencies. For example, one group reported that 19.5% (59 of 303) of primary GC tumors showed nuclear accumulation of b-catenin, but CTNNB1 mutation was detected in only 5% (4 of 77) of the tumors (Woo et al, 2001). Another group analysed 311 primary GCs and observed nuclear b-catenin in 90 tumors (29%).…”

Section: Discussionmentioning

confidence: 99%

Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer

et al. 2007

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Activation of Wnt signaling has been implicated in gastric tumorigenesis, although mutations in APC (adenomatous polyposis coli), CTNNB1 (b-catenin) and AXIN are seen much less frequently in gastric cancer (GC) than in colorectal cancer. In the present study, we investigated the relationship between activation of Wnt signaling and changes in the expression of secreted frizzled-related protein (SFRP) family genes in GC. We frequently observed nuclear b-catenin accumulation (13/15; 87%) and detected the active form of b-catenin in most (12/16; 75%) GC cell lines. CpG methylation-dependent silencing of SFRP1, SFRP2 and SFRP5 was frequently seen among GC cell lines (SFRP1, 16/16, 100%; SFRP2, 16/ 16, 100%; SFRP5, 13/16, 81%) and primary GC specimens (SFRP1, 42/46, 91%; SFRP2, 44/46, 96%; SFRP5, 30/46, 65%), and treatment with the DNA methyltransferase inhibitor 5-aza-2 0 -deoxycytidine rapidly restored SFRP expression. Ectopic expression of SFRPs downregulated T-cell factor/lymphocyte enhancer factor transcriptional activity, suppressed cell growth and induced apoptosis in GC cells. Analysis of global expression revealed that overexpression of SFRP2 repressed Wnt target genes and induced changes in the expression of numerous genes related to proliferation, growth and apoptosis in GC cells. It thus appears that aberrant SFRP methylation is one of the major mechanisms by which Wnt signaling is activated in GC.

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Section: Discussionmentioning

confidence: 99%

Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer

et al. 2007

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“…Homeostasis of the gastrointestinal epithelium is 87 [47,[69][70][71][72][73][74][75]232] Fzd-3 [78] CTNNB1 [9,[88][89][90][91][92][93]96,97] LRP6 [228] TCF7L2 [98][99][100] PPN [79] CDH17 [80] EZH2 [81] HMGA1, HMGA2 [210,211] YY1 [86] TC1 (C8orf4) [201,202] miR-17-92 [161] mir-10a [168] has-miR-335 [166] hsa-miR-375 [163] Downregulation or function inhibition in gastric cancer Downregulation by hypermethylation Inactivation by miRNAs APC [145,146] APC [175] sFRP1, sFRP2, sFRP4, sFRP5 [78,96,149] AXIN2 [159] WIF-1 [144,149] EZF1 [78] Dkk-1, Dkk-2, Dkk-3 [59,144,148,…”

Section: Wnt/b-catenin Pathway In Gastric Carcinogenesismentioning

confidence: 99%

Role of the Wnt/β-catenin pathway in gastric cancer: An in-depth literature review

Chiurillo

2015

WJEM

270

219

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Gastric cancer remains one of the most common cancers worldwide and one of the leading cause for cancerrelated deaths. Gastric adenocarcinoma is a multifactorial disease that is genetically, cytologically and architecturally more heterogeneous than other gastrointestinal carcinomas. The identification of specific membrane, intracellular, and extracellular components of the Wnt pathway has revealed potential targets for gastric cancer therapy. High-throughput "omics" approaches will help in the search for Wnt pathway antagonist in the near future.

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“…The upregulation of COL11A1 has been regarded as a consequence of Wnt pathway activation, an important step in carcinogenesis (Reguart et al, 2005;Clevers, 2006). Several lines of evidence showed that altered expression and mutation of the genes in Wnt pathway were involved in gastric cancers (Woo et al, 2001;Clements et al, 2002;Oshima et al, 2006). It will be interesting to determine whether the role of Wnt pathway in gastric cancer is associated with COL11A1 expression.…”

Section: Potential Role Of Collagens In Gastric Cancermentioning

confidence: 99%

A Potential Role of Collagens Expression in Distinguishing Between Premalignant and Malignant Lesions in Stomach

Zhao

Zhou

et al. 2009

The Anatomical Record

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Lack of clinical biomarkers for early gastric cancer without specific early symptoms leads to delayed diagnosis, which contributes to high mortality of gastric cancer. Here, we used oligonucleotide microarray to systematically examine differential gene expression among 33 samples from normal, premalignant, and malignant lesions in stomach. A focal adhesion pathway mainly composed of collagen genes was found to have a significantly different expression profile in gastric cancers compared to premalignant lesions. A subset of collagen genes efficiently separated malignant from premalignant tissues, and two representative genes COL11A1 and COL1A1 were validated in 42 tissue samples with quantitative reverse transcription-PCR and in situ hybridization. The data above suggest that focal adhesion pathway may have a role in the pathogenesis of gastric cancer, and the expression profile of collagen genes may be a potential biomarker to distinguish malignant from premalignant lesions in stomach. Anat Rec, 292:692-700, 2009. V V C 2009 Wiley-Liss, Inc.

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Altered expression and mutation of β‐catenin gene in gastric carcinomas and cell lines

Cited by 138 publications

References 18 publications

Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer

Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer

Role of the Wnt/β-catenin pathway in gastric cancer: An in-depth literature review

A Potential Role of Collagens Expression in Distinguishing Between Premalignant and Malignant Lesions in Stomach

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