Altered Functional and Anatomical Connectivity in Schizophrenia

Camchong, Jazmin; MacDonald, Angus W.; Bell, Christopher J.; Mueller, Bryon A.; Lim, Kelvin O.

doi:10.1093/schbul/sbp131

Cited by 331 publications

(287 citation statements)

References 58 publications

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“…Rather than examining functional connections separately, Camchong et al [53] first integrated DTI and fc-fMRI to fully evaluate the anatomical interactions in white matter, and the functional connectivity of regions in the gray matter within the DMN for chronic schizophrenia. Patients have decreased functional connections in the mPFC during rest, and consistently, reduced white matter integrity in the mPFC.…”

Section: Anatomical and Functional Connectivity Within The Dmn In Schmentioning

confidence: 99%

“…Patients have decreased functional connections in the mPFC during rest, and consistently, reduced white matter integrity in the mPFC. Moreover, abnormally decreased connectivity in the mPFC of patients is correlated with positive and negative symptoms, and cognitive impairments [53].…”

Section: Anatomical and Functional Connectivity Within The Dmn In Schmentioning

confidence: 99%

“…The preliminary reports on the functional response of neural compensation for structural connectivity deficits [54,55], as well as the finding of consistently fewer alterations in both the anatomical and functional connectivity within the DMN [53], imply that it would be beneficial to explore how anatomical connectivity abnormalities mediate changes in the functional connections within the DMN in schizophrenia. It is worth mentioning that none of the three studies used DTI analysis of individual white matter tracts within the DMN.…”

Section: Anatomical and Functional Connectivity Within The Dmn In Schmentioning

confidence: 99%

“…Future studies investigating specific connections within the DMN are warranted for the more precise description of the white matter tracts affected and the functional components involved. Moreover, only one [53] of the above studies was conducted and driven by the hypothesis of DMN abnormalities in schizophrenia. Therefore, more studies combining fc-fMRI and DTI to specifically evaluate the functional and anatomical connections within the DMN are needed to confirm the current findings and further test the hypothesis of DMN abnormalities in the DMN.…”

Section: Anatomical and Functional Connectivity Within The Dmn In Schmentioning

confidence: 99%

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A Review of the Functional and Anatomical Default Mode Network in Schizophrenia

et al. 2016

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Schizophrenia is a severe mental disorder characterized by impaired perception, delusions, thought disorder, abnormal emotion regulation, altered motor function, and impaired drive. The default mode network (DMN), since it was first proposed in 2001, has become a central research theme in neuropsychiatric disorders, including schizophrenia. In this review, first we define the DMN and describe its functional activity, functional and anatomical connectivity, heritability, and inverse correlation with the task positive network. Second, we review empirical studies of the anatomical and functional DMN, and anti-correlation between DMN and the task positive network in schizophrenia. Finally, we review preliminary evidence about the relationship between antipsychotic medications and regulation of the DMN, review the role of DMN as a treatment biomarker for this disease, and consider the DMN effects of individualized therapies for schizophrenia.

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Section: Anatomical and Functional Connectivity Within The Dmn In Schmentioning

confidence: 99%

Section: Anatomical and Functional Connectivity Within The Dmn In Schmentioning

confidence: 99%

Section: Anatomical and Functional Connectivity Within The Dmn In Schmentioning

confidence: 99%

Section: Anatomical and Functional Connectivity Within The Dmn In Schmentioning

confidence: 99%

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A Review of the Functional and Anatomical Default Mode Network in Schizophrenia

et al. 2016

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“…Using DTI and fMRI, Teipel et al [100] and Greicius et al [101] showed that functional connectivity across the entire DMN is based on a distinct pattern of anatomical connectivity within the cerebral white matter. In addition, some psychiatric diseases, such as schizophrenia [102] , AD [103][104][105] , and epilepsy [106] , also demonstrate a decreased WMM connectivity within the DMN. In a recent review [4] , Hulvershorn et al used a dMRI-derived network to systematically review the dysfunctional connectivity in pediatric MDD.…”

Section: Dmri Network-based Applications In Neuropsychiatric Diseasementioning

confidence: 99%

Diffusion magnetic resonance imaging for Brainnetome: A critical review

Zuo¹,

Cheng²,

Jiang³

2012

Neurosci. Bull.

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Abstract:Increasing evidence shows that the human brain is a highly self-organized system that shows attributes of smallworldness, hierarchy and modularity. The "connectome" was conceived several years ago to identify the underpinning physical connectivities of brain networks. The need for an integration of multi-spatial and -temporal approaches is becoming apparent. Therefore, the "Brainnetome" (brain-net-ome) project was proposed. Diffusion magnetic resonance imaging (dMRI) is a non-invasive way to study the anatomy of brain networks. Here, we review the principles of dMRI, its methodologies, and some of its clinical applications for the Brainnetome. Future research in this field is discussed.

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Abnormal Functional Brain Connectivity and Personality Traits in Myotonic Dystrophy Type 1

et al. 2014

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IMPORTANCE Myotonic dystrophy type 1 (DM1), the most common muscular dystrophy observed in adults, is a genetic multisystem disorder affecting several other organs besides skeletal muscle, including the brain. Cognitive and personality abnormalities have been reported; however, no studies have investigated brain functional networks and their relationship with personality traits/disorders in patients with DM1. OBJECTIVE To use resting-state functional magnetic resonance imaging to assess the potential relationship between personality traits/disorders and changes to functional connectivity within the default mode network (DMN) in patients with DM1. DESIGN, SETTING, AND PARTICIPANTS We enrolled 27 patients with genetically confirmed DM1 and 16 matched healthy control individuals. Patients underwent personality assessment using clinical interview and Minnesota Multiphasic Personality Inventory-2 administration; all participants underwent resting-state functional magnetic resonance imaging. Investigations were conducted at the Istituto di Ricovero e Cura a

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Altered Functional and Anatomical Connectivity in Schizophrenia

Abstract: The present study shows convergent fMRI and DTI findings that are consistent with the disconnection hypothesis in schizophrenia, particularly in medial frontal regions, while adding some insight of the relationship between brain disconnectivity and behavior.

Cited by 331 publications

References 58 publications

A Review of the Functional and Anatomical Default Mode Network in Schizophrenia

A Review of the Functional and Anatomical Default Mode Network in Schizophrenia

Diffusion magnetic resonance imaging for Brainnetome: A critical review

Abnormal Functional Brain Connectivity and Personality Traits in Myotonic Dystrophy Type 1

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