Altered functional connectivity associated with cognitive impairment in neuromyelitis optica spectrum disorder

Yang, Yang; Rui, Qianyun; Wu, Xiaojuan; Chen, Xiang; Han, Shuting; Yang, Yan; Wang, Xiaoyuan; Wu, Peng; Dai, Hui; Xue, Qun; Li, Yonggang

doi:10.1016/j.msard.2022.104113

Cited by 5 publications

(3 citation statements)

References 37 publications

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“…In our study, 47.4% (18/38) of NMOSD patients suffered from cognitive deficits, they were prone to severe disability, depression, and anxiety. However, younger age and longer education duration seem to protect NMOSD patients from CI, which is in line with previous studies (Kong et al., 2022 ; Yang et al., 2022 ). Kim and colleagues also confirmed shorter education years in NMOSD‐CI patients, but they found no statistic difference in age and EDSS between groups (Kim et al., 2017 ).…”

Section: Discussionsupporting

confidence: 91%

Correlation of GABA⁺ levels in the medial prefrontal cortex and circulating follicular helper T cells in neuromyelitis optica spectrum disorder patients with cognitive impairment

Duan,

Rui,

Yang

et al. 2024

Brain and Behavior

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BackgroundNeuromyelitis optica spectrum disorder (NMOSD) associated with cognitive impairment (CI) is acknowledged. However, the underlying pathogenesis and involvement of the immune system remain unclear.ObjectivesThis study aimed to investigate the alterations in immune cells, cytokines, and GABA+ levels in NMOSD patients with cognitive deficits.MethodsThirty‐eight NMOSD patients and 38 healthy controls (HCs) were included. NMOSD patients were stratified as NMOSD‐CI and NMOSD‐CP groups. The difference in cognitive functions, Tfh and cytokines, and GABA+ levels were assessed, and their correlations were calculated.ResultsNMOSD‐CI patients showed worse performance on all cognitive tests, and the percentage of circulating follicular helper T cells (cTfh) was significantly elevated. The frequency of cTfh was positively and negatively correlated with Stroop‐A and AVLT long‐delayed scores, respectively. IL‐21 was remarkably higher in NMOSD‐CI and NMOSD‐CP. The level of GABA+ in medial prefrontal cortex (mPFC) was significantly decreased in NMOSD‐CI and was proved positively and negatively correlated with Symbol Digit Modalities Test and the frequency of circulating Tfh cells, respectively.ConclusionIn NMOSD‐CI patients, all cognitive domains were impacted, , while GABA+ levels in mPFC were decreased. GABA+ levels in NMOSD‐CI were negatively correlated with the frequency of cTfh, suggesting the underlying coupling mechanism between immune responses and neurotransmitter metabolism in CI in NMOSD patients.

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Section: Discussionsupporting

confidence: 91%

Correlation of GABA⁺ levels in the medial prefrontal cortex and circulating follicular helper T cells in neuromyelitis optica spectrum disorder patients with cognitive impairment

Duan,

Rui,

Yang

et al. 2024

Brain and Behavior

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“…Considering the complexity of the neurobiological mechanisms underlying disability in NMOSD, it is crucial to investigate the involvement of multiple functional networks. Many studies have demonstrated functional network reorganizations in NMOSD 6 – 8 , and have revealed correlations between certain static functional networks and disability or motor. Specifically, increased static functional connectivity of the basal ganglia network 9 , and working memory network 10 were correlated with lower disability score in NMOSD.…”

Section: Introductionmentioning

confidence: 99%

Temporal and topological properties of dynamic networks reflect disability in patients with neuromyelitis optica spectrum disorders

Wang,

Yang,

Zheng

et al. 2024

Sci Rep

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Approximately 36% of patients with neuromyelitis optica spectrum disorders (NMOSD) suffer from severe visual and motor disability (blindness or light perception or unable to walk) with abnormalities of whole-brain functional networks. However, it remains unclear how whole-brain functional networks and their dynamic properties are related to clinical disability in patients with NMOSD. Our study recruited 30 NMOSD patients (37.70 ± 11.99 years) and 45 healthy controls (HC, 41.84 ± 11.23 years). The independent component analysis, sliding-window approach and graph theory analysis were used to explore the static strength, time-varying and topological properties of large-scale functional networks and their associations with disability in NMOSD. Compared to HC, NMOSD patients showed significant alterations in dynamic networks rather than static networks. Specifically, NMOSD patients showed increased occurrence (fractional occupancy; P < 0.001) and more dwell times of the low-connectivity state (P < 0.001) with fewer transitions (P = 0.028) between states than HC, and higher fractional occupancy, increased dwell times of the low-connectivity state and lower transitions were related to more severe disability. Moreover, NMOSD patients exhibited altered small-worldness, decreased degree centrality and reduced clustering coefficients of hub nodes in dynamic networks, related to clinical disability. NMOSD patients exhibited higher occurrence and more dwell time in low-connectivity states, along with fewer transitions between states and decreased topological organizations, revealing the disrupted communication and coordination among brain networks over time. Our findings could provide new perspective to help us better understand the neuropathological mechanism of the clinical disability in NMOSD.

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“…In the last two decades, noninvasive MRI techniques have been a critical component for understanding brain reorganization in NMOSD. By employing a range of structural and functional MRI (fMRI) techniques and analytic metrics, significant changes in brain gray matter volume (8)(9)(10)(11), cortical thickness (12), white matter volume (10, 13,14), white matter microstructure (15), resting-state regional homogeneity (16), spontaneous neuronal activity (17), cerebral blood flow (18), neurovascular coupling (19), functional connectivity (11,(20)(21)(22), and structural and functional networks (21,(23)(24)(25)(26)(27)(28)(29) have been observed in NMOSD. These changes have been linked to visual impairment, cognitive dysfunction, fatigue, disease severity, disease duration, and other clinical features in NMOSD.…”

Section: Introductionmentioning

confidence: 99%

Abnormal brain spontaneous neural activity in neuromyelitis optica spectrum disorder with neuropathic pain

Wang,

Chen,

Wang

et al. 2024

Front. Neurol.

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BackgroundNeuropathic pain is one of the most common symptoms in neuromyelitis optica spectrum disorder (NMOSD). Notwithstanding, its underlying mechanism remains obscure.MethodsThe amplitude of low-frequency fluctuations (ALFF) metric was employed to investigate spontaneous neural activity alterations via resting-state functional magnetic resonance imaging (rs-MRI) data from a 3.0 T MRI scanner, in a sample of 26 patients diagnosed with NMOSD with neuropathic pain (NMOSD-WNP), 20 patients with NMOSD but without neuropathic pain (NMOSD-WoNP), and 38 healthy control (HC) subjects matched for age and sex without the comorbidity of depressive or anxious symptoms.ResultsIt was observed that patients with NMOSD-WNP displayed a significant ALFF decrease in the left amygdala and right anterior insula, relative to both patients with NMOSD-WoNP and HC subjects. Furthermore, ALFF values in the left amygdala were negatively correlated with the scores of the Douleur Neuropathique en 4 Questions and McGill Pain Questionnaire (both sensory and affective descriptors) in patients with NMOSD-WNP. Additionally, there were negative correlations between the ALFF values in the right anterior insula and the duration of pain and the number of relapses in patients with NMOSD-WNP.ConclusionThe present study characterizes spontaneous neural activity changes in brain regions associated with sensory and affective processing of pain and its modulation, which underscore the central aspects in patients with NMOSD-WNP. These findings might contribute to a better understanding of the pathophysiologic basis of neuropathic pain in NMOSD.

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Altered functional connectivity associated with cognitive impairment in neuromyelitis optica spectrum disorder

Cited by 5 publications

References 37 publications

Correlation of GABA⁺ levels in the medial prefrontal cortex and circulating follicular helper T cells in neuromyelitis optica spectrum disorder patients with cognitive impairment

Correlation of GABA⁺ levels in the medial prefrontal cortex and circulating follicular helper T cells in neuromyelitis optica spectrum disorder patients with cognitive impairment

Temporal and topological properties of dynamic networks reflect disability in patients with neuromyelitis optica spectrum disorders

Abnormal brain spontaneous neural activity in neuromyelitis optica spectrum disorder with neuropathic pain

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Altered functional connectivity associated with cognitive impairment in neuromyelitis optica spectrum disorder

Cited by 5 publications

References 37 publications

Correlation of GABA+ levels in the medial prefrontal cortex and circulating follicular helper T cells in neuromyelitis optica spectrum disorder patients with cognitive impairment

Correlation of GABA+ levels in the medial prefrontal cortex and circulating follicular helper T cells in neuromyelitis optica spectrum disorder patients with cognitive impairment

Temporal and topological properties of dynamic networks reflect disability in patients with neuromyelitis optica spectrum disorders

Abnormal brain spontaneous neural activity in neuromyelitis optica spectrum disorder with neuropathic pain

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Correlation of GABA⁺ levels in the medial prefrontal cortex and circulating follicular helper T cells in neuromyelitis optica spectrum disorder patients with cognitive impairment

Correlation of GABA⁺ levels in the medial prefrontal cortex and circulating follicular helper T cells in neuromyelitis optica spectrum disorder patients with cognitive impairment