Altered functional connectivity within and between resting-state networks in patients with vestibular migraine

Han, Lin; Lu, Jiajie; Chen, Can; Ke, Jun; Zhao, Hongru

doi:10.1007/s00234-022-03102-9

Cited by 10 publications

(8 citation statements)

References 45 publications

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“…Functional magnetic resonance imaging has been shown to be a useful tool for evaluating various neurological disorders (e.g., vestibular migraine and Alzheimer’s disease) and describing the changes in functional connectivity as a potential predictor of cognitive dysfunction [ 59 , 60 ]. Thus, Askren et al demonstrated that the spatial variance in executive network activation, detected in women before chemotherapy for breast cancer, is able to predict the severity of cognitive impairment and fatigue following the treatment [ 61 ].…”

Section: Discussionmentioning

confidence: 99%

Elevated Levels of Serum Biomarkers Associated with Damage to the CNS Neurons and Endothelial Cells Are Linked with Changes in Brain Connectivity in Breast Cancer Patients with Vestibulo-Atactic Syndrome

Nikolaeva,

Pospelova,

Krasnikova

et al. 2023

Pathophysiology

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Vestibulo-atactic syndrome (VAS), which represents a combination of motor and vestibular disorders, can be manifested as a clinical complication of breast cancer treatment and has a significant impact on patients’ quality of life. The identification of novel potential biomarkers that might help to predict the onset of VAS and its progression could improve the management of this group of patients. In the current study, the levels of intercellular cell adhesion molecule 1 (ICAM-1), platelet/endothelial cell adhesion molecule 1 (PECAM-1), NSE (neuron-specific enolase), and the antibodies recognizing NR-2 subunit of NMDA receptor (NR-2-ab) were measured in the blood serum of BC survivor patients with vestibulo-atactic syndrome (VAS) and associated with the brain connectome data obtained via functional magnetic resonance imaging (fMRI) studies. A total of 21 patients were registered in this open, single-center trial and compared to age-matched healthy female volunteers (control group) (n = 17). BC patients with VAS demonstrated higher serum levels of ICAM-1, PECAM-1, and NSE and a lower value of NR-2-ab, with values of 654.7 ± 184.8, 115.3 ± 37.03, 49.9 ± 103.9, and 0.5 ± 0.3 pg/mL, respectively, as compared to the healthy volunteers, with 230.2 ± 44.8, 62.8 ± 15.6, 15.5 ± 6.4, and 1.4 ± 0.7 pg/mL. According to the fMRI data (employing seed-to-voxel and ROI-to-ROI methods), in BC patients with VAS, significant changes were detected in the functional connectivity in the areas involved in the regulation of postural-tonic reflexes, the coordination of movements, and the regulation of balance. In conclusion, the detected elevated levels of serum biomarkers may reveal damage to the CNS neurons and endothelial cells that is, in turn, associated with the change in the brain connectivity in this group of patients.

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Section: Discussionmentioning

confidence: 99%

Elevated Levels of Serum Biomarkers Associated with Damage to the CNS Neurons and Endothelial Cells Are Linked with Changes in Brain Connectivity in Breast Cancer Patients with Vestibulo-Atactic Syndrome

Nikolaeva,

Pospelova,

Krasnikova

et al. 2023

Pathophysiology

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“…During the process of screening, the overlapping datasets that used diverse seeds were considered different datasets. After duplicate removal and literature screening, nine studies (Chen et al, 2023(Chen et al, , 2022Han et al, 2023;Li et al, 2023Li et al, , 2022Wang et al, 2023;Zhe et al, 2023;Zhe et al, 2021a,b) were finally eligible for the analysis, comprising 251 VM patients and 257 HCs. Table 1 and Table S10 describe the detailed information of the included studies.…”

Section: Including Studies and Quality Assessmentmentioning

confidence: 99%

“…To date, several studies have found significant FC alterations in multiple brain areas in VM, which were mainly distributed in the anterior cingulate/midcingulate cortex (Chen et al, 2023(Chen et al, , 2022Wang et al, 2023;Zhe et al, 2023), middle frontal gyrus (MFG) (Chen et al, 2023(Chen et al, , 2022Zhe et al, 2021b), precuneus (Chen et al, 2023(Chen et al, , 2022, insular cortex (Chen et al, 2023(Chen et al, , 2022, supplementary motor area (Chen et al, 2022;Zhe et al, 2021a,b), superior frontal gyrus (Wang et al, 2023;Zhe et al, 2021a), left inferior frontal gyrus (Han et al, 2023), and temporal lobe (Li et al, 2023;Zhe et al, 2021a). However, the results of these studies showed great divergences and even conflicting findings.…”

Section: Introductionmentioning

confidence: 99%

The altered functional status in vestibular migraine: A meta‐analysis

Du,

Liu,

Zhu

2024

Brain and Behavior

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PurposeVestibular migraine (VM) is a disorder with prominent vestibular symptoms that are causally correlated with migraine and is the most prevalent neurological cause of episodic vertigo. Nevertheless, the functional underpinnings of VM remain largely unclear. This study aimed to reveal concordant alteration patterns of functional connectivity (FC) in VM patients.MethodsWe searched literature measuring resting‐state FC abnormalities of VM patients in PubMed, Embase, Cochrane, and Scopus databases before May 2023. Furthermore, we applied the anisotropic effect size‐signed differential mapping (AES‐SDM) to conduct a whole‐brain voxel‐wise meta‐analysis to identify the convergence of FC alterations in VM patients.ResultsNine studies containing 251 VM patients and 257 healthy controls (HCs) were included. Relative to HCs, VM patients showed reduced activity in the left superior temporal gyrus and left midcingulate/paracingulate gyri, and increased activity in the precuneus, right superior parietal gyrus, and right middle frontal gyrus. Jackknife's analysis and subgroup analysis further supported the generalization and robustness of the main results. Furthermore, meta‐regression analyses indicated that the Dizziness Handicap Inventory (DHI) ratings were positively correlated with the activity in the precuneus, while higher Headache Impact Test‐6 and DHI scores were associated with lower activity within the left midcingulate/paracingulate gyri.ConclusionsThe study indicates that VM is associated with specific functional deficits of VM patients in crucial regions involved in the vestibular and pain networks and provides further information on the pathophysiological mechanisms of VM.

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“…Thus, resting-state fMRI is much easier to carry out and has been increasingly used in recent VM studies. Previous resting-state fMRI studies on VM mainly adopted analytic methods of amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), regional homogeneity (ReHo), functional connectivity (FC), data-driven voxel-wise degree centrality (DC), independent component analysis (ICA), functional network connectivity (FNC), dynamic ALFF and ReHo, and dynamic FNC, etc [18][19][20][21][22][23][24][25][26][27]. .…”

Section: Introductionmentioning

confidence: 99%

Aberrant cerebral blood flow and functional connectivity in patients with vestibular migraine: a resting-state ASL and fMRI study

Chen,

Liu,

Lin

et al. 2024

J Headache Pain

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Background Prior neuroimaging studies on vestibular migraine (VM) have extensively certified the functional and structural alterations in multiple brain regions and networks. However, few studies have assessed the cerebral blood flow (CBF) in VM patients using arterial spin labeling (ASL). The present study aimed to investigate CBF and functional connectivity (FC) alterations in VM patients during interictal periods. Methods We evaluated 52 VM patients and 46 healthy controls (HC) who received resting-state pseudo-continuous ASL and functional magnetic resonance imaging (fMRI) scanning. Comparisons of voxel-based CBF and seed-based FC were performed between the two groups. Brain regions showed significant group differences in CBF analyses were chosen as seeds in FC analyses. Additionally, the associations between abnormal imaging results and clinical features were explored. Results Compared with HC, VM patients showed higher normalized CBF in the right precentral gyrus (PreCG), left postcentral gyrus (PostCG), left superior frontal gyrus and bilateral insular (p < 0.05, FDR corrected). Furthermore, VM patients exhibited increased FC between the right PreCG and areas of the left PostCG, left cuneus and right lingual gyrus (p < 0.05, FDR corrected). In addition, we observed decreased FC between the left insular and regions of the left thalamus and right anterior cingulate cortex, as well as increased FC between the left insular and right fusiform gyrus in VM patients (p < 0.05, FDR corrected). Moreover, these variations in brain perfusion and FC were significantly correlated with multiple clinical features including frequency of migraine symptoms, frequency of vestibular symptoms and disease duration of VM (all p < 0.05). Conclusions Patients with VM during interictal period showed hyperperfusion and abnormal resting-state FC in brain regions potentially contributed to disrupted multi-sensory and autonomic processing, as well as impaired ocular motor control, pain modulation and emotional regulation. Our study provided novel insights into the complex neuropathology of VM from a CBF perspective.

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Altered functional connectivity within and between resting-state networks in patients with vestibular migraine

Cited by 10 publications

References 45 publications

Elevated Levels of Serum Biomarkers Associated with Damage to the CNS Neurons and Endothelial Cells Are Linked with Changes in Brain Connectivity in Breast Cancer Patients with Vestibulo-Atactic Syndrome

Elevated Levels of Serum Biomarkers Associated with Damage to the CNS Neurons and Endothelial Cells Are Linked with Changes in Brain Connectivity in Breast Cancer Patients with Vestibulo-Atactic Syndrome

The altered functional status in vestibular migraine: A meta‐analysis

Aberrant cerebral blood flow and functional connectivity in patients with vestibular migraine: a resting-state ASL and fMRI study

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