Altered functional neuronal activity in neuropsychiatric lupus: A systematic review of the fMRI investigations

Mikdashi, Jamal

doi:10.1016/j.semarthrit.2015.08.002

Cited by 43 publications

(30 citation statements)

References 29 publications

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“…The alterations in the network efficiencies in the patients reflected a disruption in the topological organization because of a disease. These findings were consistent with the insufficient effective integration among the distributed functional cortical regions reported in a previous SLE fMRI study (Mikdashi, 2016). In addition, the increased short path represented prolonged optimal interactions among the neurons, which are essential for functional cognitive processes within and across the brain regions (Sporns and Zwi, 2004).…”

Section: Discussionsupporting

confidence: 93%

Alterations of white matter structural networks in patients with non-neuropsychiatric systemic lupus erythematosus identified by probabilistic tractography and connectivity-based analyses

Tan

Zhang

et al. 2017

NeuroImage: Clinical

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PurposeSystemic lupus erythematosus (SLE) is a chronic inflammatory female-predominant autoimmune disease that can affect the central nervous system and exhibit neuropsychiatric symptoms. In SLE patients without neuropsychiatric symptoms (non-NPSLE), recent diffusion tensor imaging studies showed white matter abnormalities in their brains. The present study investigated the entire brain white matter structural connectivity in non-NPSLE patients by using probabilistic tractography and connectivity-based analyses.MethodsWhole-brain structural networks of 29 non-NPSLE patients and 29 healthy controls (HCs) were examined. The structural networks were constructed with interregional probabilistic connectivity. Graph theory analysis was performed to investigate the topological properties, and network-based statistic was employed to assess the alterations of the interregional connections among non-NPSLE patients and controls.ResultsCompared with HCs, non-NPSLE patients demonstrated significantly decreased global and local network efficiencies and showed increased characteristic path length. This finding suggests that the global integration and local specialization were impaired. Moreover, the regional properties (nodal efficiency and degree) in the frontal, occipital, and cingulum regions of the non-NPSLE patients were significantly changed and negatively correlated with the disease activity index. The distribution pattern of the hubs measured by nodal degree was altered in the patient group. Finally, the non-NPSLE group exhibited decreased structural connectivity in the left median cingulate-centered component and increased connectivity in the left precuneus-centered component and right middle temporal lobe-centered component.ConclusionThis study reveals an altered topological organization of white matter networks in non-NPSLE patients. Furthermore, this research provides new insights into the structural disruptions underlying the functional and neurocognitive deficits in non-NPSLE patients.

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Section: Discussionsupporting

confidence: 93%

Alterations of white matter structural networks in patients with non-neuropsychiatric systemic lupus erythematosus identified by probabilistic tractography and connectivity-based analyses

Tan

Zhang

et al. 2017

NeuroImage: Clinical

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“…CBF significantly increased in GM in the temporal gyrus, cingulate gyrus, and cerebellum regions and in widespread WM in non‐NPSLE patients compared with NCs. We hypothesized that this result may be caused by a compensatory mechanism in response to ischemia or injury, which was consistent with previous fMRI studies showing hyperactivities and hyperconnectivity within certain specific networks (e.g., the sensorimotor network) (Mikdashi, ; Niu et al, ; Nystedt et al, ; Papadaki et al, ; Wu et al, ; Zhang et al, ). However, in NPSLE patients, along with widespread vasculopathy and thrombosis, the perfusion of these brain regions was significantly decreased, which means a large reduction in compensatory capacity when the damage exceeded the threshold.…”

Section: Discussionsupporting

confidence: 86%

Different patterns of cerebral perfusion in SLE patients with and without neuropsychiatric manifestations

Zhuo

Duan

et al. 2019

Human Brain Mapping

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To investigate brain perfusion patterns in systemic lupus erythematosus (SLE) patients with and without neuropsychiatric systemic lupus erythematosus (NPSLE and non-NPSLE, respectively) and to identify biomarkers for the diagnosis of NPSLE using noninvasive three-dimensional (3D) arterial spin labeling (ASL). Thirty-one NPSLE and 24 non-NPSLE patients and 32 age-and sex-matched normal controls (NCs) were recruited. Three-dimensional ASL-MRI was applied to quantify cerebral perfusion. Whole brain, gray (GM) and white matter (WM), and voxel-based analysis (VBA) were performed to explore perfusion characteristics. Correlation analysis was performed to find the relationship between the perfusion measures, lesion volumes, and clinical variables. Receiver operating characteristic (ROC) analysis and support vector machine (SVM) classification were applied to differentiate NPSLE patients from non-NPSLE patients and healthy controls. Compared to NCs, NPSLE patients showed increased cerebral blood flow (CBF) within WM but decreased CBF within GM, while non-NPSLE patients showed increased CBF within both GM and WM. Compared to non-NPSLE patients, NPSLE patients showed significantly reduced CBF in the frontal gyrus, cerebellum, and corpus callosum. CBF within several brain regions such as cingulate and corpus callosum showed significant correlations with the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and the Systemic Lupus International Collaborating Clinics (SLICC) damage index scores. ROC analysis showed moderate performance in distinguishing NPSLE from non-NPSLE patients with AUCs > 0.7, while SVM analysis demonstrated that CBF within the corpus callosum achieved an accuracy of 83.6% in distinguishing NPSLE from non-NPSLE patients. Different brain perfusion patterns were observed between NPSLE and non-NPSLE patients. CBF measured by noninvasive 3D ASL could be a useful biomarker for the diagnosis and disease monitoring of NPSLE and non-NPSLE patients. K E Y W O R D S 3D arterial spin labeling, neuropsychiatric systemic lupus erythematosus, perfusion, systemic lupus erythematosus Zhizheng Zhuo and Li Su contributed equally to this study.

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“…Disappointingly, no features useful for characterizing patients with NP-SLE were identified. Using different methods, abnormalities in WM microstructure and functional activity have been demonstrated mainly in patients with NP involvement, but they have also been detected in patients without, although to a lesser extent [9][10][11][12][13][14][15]. The 1999 ACR criteria to define NP involvement [4] are based on heterogeneous manifestations possibly associated with extreme variability of brain damage.…”

Section: Peripheral Nervous System Involvementmentioning

confidence: 99%

Structural and functional brain connectomes in patients with systemic lupus erythematosus

Preziosa

Rocca

Ramirez

et al. 2019

Euro J of Neurology

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Background and purpose Systemic lupus erythematosus (SLE) is an immune‐mediated disease that may affect the nervous system. We explored the topographical organization of structural and functional brain connectivity in patients with SLE and its correlation with neuropsychiatric (NP) involvement and autoantibody profiles. Methods Graph theoretical analysis was applied to diffusion tensor magnetic resonance imaging (MRI) and resting‐state functional MRI data from 32 patients with SLE and 32 age‐ and sex‐matched healthy controls. Structural and functional connectivity matrices between 116 cortical/subcortical brain regions were estimated using a bivariate correlation analysis, and global and nodal network metrics were calculated. Results Structural, but not functional, global network properties (strength, transitivity, global efficiency and path length) were abnormal in patients with SLE versus controls (P < 0.0001), especially in patients with anti‐double‐stranded DNA (ADNA) autoantibodies (P = 0.03). No difference was found according to NP involvement or anti‐phospholipid autoantibody status. Patients with SLE and controls shared identical structural hubs and the majority of functional hubs. In patients with SLE, all structural hubs showed reduced strength and clustering coefficient compared with controls (P from 0.001 to <0.0001), especially in patients with ADNA autoantibodies. Only a few differences in functional hub properties were found between patients with SLE and controls. Structural and functional hub measures did not differ according to NP involvement or anti‐phospholipid autoantibody status. Significant correlations were found between clinical, MRI and network measures (r from −0.56 to 0.60, P from 0.0003 to 0.05). Conclusions Abnormalities of global and nodal structural connectivity occur in patients with SLE, especially with ADNA autoantibodies, with a diffuse disruption of structural integrity. Functional network integrity may contribute to preserve clinical functions.

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Altered functional neuronal activity in neuropsychiatric lupus: A systematic review of the fMRI investigations

Cited by 43 publications

References 29 publications

Alterations of white matter structural networks in patients with non-neuropsychiatric systemic lupus erythematosus identified by probabilistic tractography and connectivity-based analyses

Alterations of white matter structural networks in patients with non-neuropsychiatric systemic lupus erythematosus identified by probabilistic tractography and connectivity-based analyses

Different patterns of cerebral perfusion in SLE patients with and without neuropsychiatric manifestations

Structural and functional brain connectomes in patients with systemic lupus erythematosus

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