Altered insulin sensitivity, hyperinsulinemia, and dyslipidemia in individuals with a hypertensive parent

Ferrari, Paolo; Weidmann, P; Shaw, Sidney; Giachino, Daniel; Riesen, Walter; Allemann, Yves; Heynen, G

doi:10.1016/0002-9343(91)90211-f

Cited by 207 publications

(99 citation statements)

References 33 publications

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“…29 Previous studies have shown that early stages of both insulin and lipid metabolism alterations are present in young normotensive offspring of hypertensive parents that are matched for gender, age and BMI but not for BP levels. 7,19,24,25,28 This study showed that these early insulin and metabolism alterations also occur in young normotensive female offsprings of hypertensive parents before any increase in BP levels.…”

Section: Lipids Glucose and Insulinmentioning

confidence: 55%

“…Because of the small sample size, the higher low-density lipoprotein-cholesterol levels observed in FH þ þ group, as well as observed in the FH þ group (B18 mg 100 ml À1 ), cannot be dismissed because of the absence of statistical significance, and may have important clinical relevance. Higher low-density lipoprotein-cholesterol levels among normotensive offsprings of hypertensive parents compared with normotensive with normotensive parents have been shown by some investigators, 7,19,24,25,28 although negative finds exist. 18,26 Abnormalities in lipids, glucose and insulin metabolism have been found to be part of a complex of cardiovascular risk factors commonly found in hypertensive subjects.…”

Section: Lipids Glucose and Insulinmentioning

confidence: 92%

“…The existence of early abnormalities of glucose and insulin metabolism among offsprings of hypertensive parents has been confirmed by some investigators, 7,19,[24][25][26] although not by all. 15,27 Previous studies have shown elevated fasting insulin and insulin-to- Early abnormalities in family hypertension EG Ciolac et al glucose levels, as well as reduced sensitivity of insulin-mediated cellular glucose disposal, in normotensive offspring of hypertensive parents; however, data have not been analysed separately by neither gender nor parental burden.…”

Section: Lipids Glucose and Insulinmentioning

confidence: 95%

“…15,27 Previous studies have shown elevated fasting insulin and insulin-to- Early abnormalities in family hypertension EG Ciolac et al glucose levels, as well as reduced sensitivity of insulin-mediated cellular glucose disposal, in normotensive offspring of hypertensive parents; however, data have not been analysed separately by neither gender nor parental burden. 7,[24][25][26] The only study we have known that assayed fasting insulin and insulin resistance in normotensive with three different parental hypertension burden showed that normotensive offspring of two hypertensive parents had elevated plasma insulin levels and were more likely to show greater insulin resistance than normotensive individuals having either one hypertensive parent or normotensive parents; however, the data were also not analysed separately by gender. 19 This study demonstrated that insulin and insulin-toglucose ratio (a marker of insulin resistance) were higher in both women with two or one hypertensive parents than in women with normotensive parents, when a population of young normotensive women matched for age, menstrual cycle phase, BMI and BP levels were analysed.…”

Section: Lipids Glucose and Insulinmentioning

confidence: 99%

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Haemodynamic, metabolic and neuro-humoral abnormalities in young normotensive women at high familial risk for hypertension

Ciolac

Bocchi²,

Bortolotto³

et al. 2010

J Hum Hypertens

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We analysed the haemodynamic, metabolic and hormonal status at rest and in response to exercise, in young normotensive women with two hypertensive parents (FH þ þ ; n ¼ 17; 25.1±4.8 years), one hypertensive parent (FH þ ; n ¼ 18; 24.9 ± 4.1 years) and normotensive parents (FHÀ; n ¼ 15; 25.3 ± 3.8 years). Casual and ambulatorial blood pressure (BP), carotid-femoral pulse wave velocity (PWV) and biochemistry were analysed. BP, nor-epinephrine (NE), epinephrine (EPI), endothelin-1 (ET-1) and nitrite/nitrate (NOx) levels were also analysed during a graded exercise test (GXT). Casual and ambulatorial BP were not different between groups, but PWV was 7.5 and 12.6% higher in FH þ þ than FH þ and FHÀ, respectively, and 4.8% higher in FH þ than FHÀ (Pp0.01). Insulin and insulin-to-glucose ratio were increased in FH þ þ and FH þ (Po0.05), and lowdensity lipoprotein (LDL)-cholesterol tended to be higher only in FH þ þ (P ¼ 0.07). FH þ þ showed higher exercise and recovery diastolic BP and EPI levels, and increased resting, exercise and recovery NE, and ET-1 levels than FHÀ (Po0.05). FH þ showed only greater resting, exercise and recovery NE, and rest ET-1 (Po0.05). Resting, exercise and recovery NOx were lower in FH þ þ and FH þ than FHÀ (Po0.01). Haemodynamic, metabolic and hormonal abnormalities were presented in nonhypertensive young women offspring of hypertensive parents before any increase in BP. Greater abnormalities were observed in women with a strong family history of hypertension (FH þ þ ). These results suggest that there is an early vascular, metabolic and hormonal involvement in a familial hypertensive disorder.

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Section: Lipids Glucose and Insulinmentioning

confidence: 55%

Section: Lipids Glucose and Insulinmentioning

confidence: 92%

Section: Lipids Glucose and Insulinmentioning

confidence: 95%

Section: Lipids Glucose and Insulinmentioning

confidence: 99%

See 2 more Smart Citations

Haemodynamic, metabolic and neuro-humoral abnormalities in young normotensive women at high familial risk for hypertension

Ciolac

Bocchi²,

Bortolotto³

et al. 2010

J Hum Hypertens

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show abstract

“…[3][4][5][6][7] This might indicate that insulin resistance precedes the rise in blood pressure. However, to our knowledge no prospective study has demonstrated the predictive value of insulin resistance with respect to glucose metabolism for the development of hypertension.…”

Section: Introductionmentioning

confidence: 99%

Insulin sensitivity with respect to glucose metabolism in hypertension-prone men did not predict the blood pressure increase in 5 years

2001

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Objectives: To evaluate peripheral insulin stimulated glucose uptake as a predictor for increase in blood pressure in hypertension-prone men. Design: A follow-up study 5 years after a primary investigation that included an euglycaemic hyperinsulinaemic clamp to evaluate insulin sensitivity. Subjects: Thirty-two men with a family history of hypertension (relatives) and 22 men with no hypertension in the family (controls). All were normotensive and had a normal glucose tolerance. Main outcome measures: Change in blood pressure over 5 years and its relation to the values obtained in the basal investigation. Results: Systolic and diastolic blood pressure increased in both groups during the 5 years, but dia-

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Coronary Artery Disease Risk Factors From a Genetic and Developmental Perspective

Slyper

Schectman²

1994

Arch Intern Med

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The genetic nature of obesity, hypertension, non-insulin-dependent diabetes, and low-density lipoprotein levels was reviewed. Obesity, hypertension, and diabetes are evolving conditions that are associated with early changes in lipid and carbohydrate metabolism. An appreciation of the genetic nature of these conditions should be useful in devising screening strategies for family members who are at risk for coronary artery disease because of their family history.

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Altered insulin sensitivity, hyperinsulinemia, and dyslipidemia in individuals with a hypertensive parent

Cited by 207 publications

References 33 publications

Haemodynamic, metabolic and neuro-humoral abnormalities in young normotensive women at high familial risk for hypertension

Haemodynamic, metabolic and neuro-humoral abnormalities in young normotensive women at high familial risk for hypertension

Insulin sensitivity with respect to glucose metabolism in hypertension-prone men did not predict the blood pressure increase in 5 years

Coronary Artery Disease Risk Factors From a Genetic and Developmental Perspective

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