Altered inter-hemispheric communication of default-mode and visual networks underlie etiology of primary insomnia

Dai, Xuesong; Liu, Bixia; Ai, Sizhi; Nie, Xin; Xu, Qiang; Hu, Jianping; Zhang, Qirui; Xu, Yin; Zhang, Zhiqiang; Lu, Guangming

doi:10.1007/s11682-019-00064-0

Cited by 35 publications

(61 citation statements)

References 66 publications

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“…The ventral pathway down to the fusiform gyrus and middle temporal gyrus (BA 20, 37), and the dorsal pathway down to the posterior parietal lobe. 37,44 In the present study, both pathways of the sensory area showed regional neuronal brain activity deficits.…”

Section: Roc Curvesupporting

confidence: 54%

“…Recently, receiver operating characteristic (ROC) curve was increasingly used to identify whether one imaging parameter could be served as a potential biomarker to discriminate between two different groups. 16,17,22,36,37 Here, the ROC curve was applied to identify the ability of the proposed fALFF method in distinguishing the SLFECS group from the NCs group. Pearson's correlation analysis was applied to calculate the relationships between the regional brain activity deficits and behavioral data.…”

Section: Discussionmentioning

confidence: 99%

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Self‐limited focal epilepsy decreased regional brain activity in sensorimotor areas

Chen

Shen

2020

Acta Neurol Scand

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Self-limited focal epilepsy with centrotemporal spikes (SLFECS) is the most common type of idiopathic epilepsy in childhood, 1 affecting about 15.7% of epilepsy with 75% starting at 7 ~ 10 years. 2,3 Although most SLFECS patients generally only have a few seizures and have a good prognosis, some SLFECS patients also exhibit several cognitive and behavioral problems, such as processing speed, reading,

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Section: Roc Curvesupporting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Self‐limited focal epilepsy decreased regional brain activity in sensorimotor areas

Chen

Shen

2020

Acta Neurol Scand

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“…To our knowledge, this is the first study to investigate the dynamic modulation of SD on VMHC. VMHC has been broadly used to reveal aberrant interhemispheric functional connectivity in various brain disorders, such as insomnia, 16 schizophrenia, 17 and nicotine addiction. 6 Using repeated fMRI scanning, we found significant alterations in VMHC during one night of SD, which indicated that functional interhemispheric communication was severely affected by SD.…”

Section: Discussionmentioning

confidence: 99%

<p>Gradually Increased Interhemispheric Functional Connectivity During One Night of Sleep Deprivation</p>

Zhu¹,

Ren²,

Zhu³

et al. 2020

NSS

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Background: It is well known that circadian rhythms and sleep homeostasis contribute to a pronounced trough in sleepiness and behavioral performance at night. However, the underlying neuroimaging mechanisms remain unclear. How brain-function connectivity is modulated during sleep deprivation (SD) has been rarely examined. Methods: By increasing the number of scanning sessions during SD, the current study used voxel-mirrored homotopic connectivity (VMHC) to investigate dynamic changes in interhemispheric communication during one night of SD. Every 2 hours from 10 pm to 06 am (session 1, 10 pm; session 2, 12 am; session 3, 2 am; session 4, 4 am; session 5, 6 am), functional magnetic resonance-imaging data and Stanford Sleepiness Scale (SSS) scores were collected from 36 healthy participants with intermediate chronotype. Dynamic changes in SSS scores and VMHC were determined using one-way repeated-measure ANOVA with the false discovery-rate method to correct for multiple comparisons. Results: Significant time effects for VMHC were found mainly in the bilateral thalamus, bilateral superior temporal gyrus, and bilateral precentral gyrus. SSS scores and VMHC in these areas were both found to be monotonously increased during SD. Furthermore, significant positive associations were found between SSS valu and VMHC values in the left superior temporal and right superior gyri. Conclusion: These findings might represent the dynamic modulation of circadian rhythm merely or the interaction effects of both circadian rhythm and sleep homeostasis on interhemispheric connectivity within the thalamus, default-mode network, and sensorimotor network. Our study provides more comprehensive information on how SD regulates brain connectivity between hemispheres and adds new evidence of neuroimaging correlates of increased sleepiness after SD.

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“…Recently, ROC curve was increasingly applied into the exploration of the reliability of one neuroimaging parameter as a potential biological indicator in distinguishing one group from another group (8, 16, 29–31). The mean beta values of those brain regions exhibiting abnormal fALFF in RRMS relative to HGs were entered into ROC curve analysis.…”

Section: Methodsmentioning

confidence: 99%

Relapsing-Remitting Multiple Sclerosis Is Associated With Regional Brain Activity Deficits in Motor- and Cognitive-Related Brain Areas

Liu

Hua

et al. 2019

Front. Neurol.

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Objective: To identify the abnormal regional spontaneous brain activity associated with relapsing-remitting multiple sclerosis (RRMS) using fractional amplitude of low-frequency fluctuation (fALFF) analysis and their relationships with clinical features.Methods: A total of 26 RRMS (11 males, 15 females; age, 36.58 ± 10.82 years) and 27 status-matched healthy group (HGs; 12 males, 15 females; age, 35.85 ± 12.05 years) underwent an Expanded Disability Status Scale (EDSS) examination. fALFF was applied to evaluate the abnormal regional brain activity associated with RRMS. Pearson's correlation analysis was applied to calculate the correlations between the signal values of brain areas that exhibited abnormal fALFF values and clinical features. Receiver operating characteristic (ROC) curve was performed to evaluate the sensitivity and specificity of those altered brain areas to distinguish between RRMS and HGs.Results: Compared with HGs, RRMS exhibited higher fALFF in the right cerebellum posterior lobe, left orbitofrontal cortex, left dorsolateral prefrontal cortex, bilateral supplementary motor area, and right fusiform gyrus and lower fALFF values in the left hippocampus and right precuneus. ROC revealed that these areas showed two good and five fair AUC values (0.77 ± 0.03, 0.729~0.822). However, four combinations with more than five brain regions received the same best discriminatory power with a sensitivity of 96.3% and a specificity of 88.5%. EDSS revealed a negative correlation with supplementary motor area (r = −0.395, p = 0.046).Conclusions: RRMS is associated with abnormal regional brain activity deficits of motor- and cognitive-related areas. The fALFF parameter may serve as a potential biological marker to discriminate between the two groups.

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Altered inter-hemispheric communication of default-mode and visual networks underlie etiology of primary insomnia

Cited by 35 publications

References 66 publications

Self‐limited focal epilepsy decreased regional brain activity in sensorimotor areas

Self‐limited focal epilepsy decreased regional brain activity in sensorimotor areas

<p>Gradually Increased Interhemispheric Functional Connectivity During One Night of Sleep Deprivation</p>

Relapsing-Remitting Multiple Sclerosis Is Associated With Regional Brain Activity Deficits in Motor- and Cognitive-Related Brain Areas

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