Altered levels of circulating mitochondrial DNA in elderly people with sarcopenia: Association with mitochondrial impairment

Fan, Zhen; Yang, Jingyu; Guo, Yi; Liu, Yaoxia; Zhong, Xiao-yi

doi:10.1016/j.exger.2022.111802

Cited by 25 publications

(8 citation statements)

References 30 publications

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“…Additionally, cytosolic mtDNA engages the DNA sensor cGAS and promotes STING-IRF3-dependent signaling to promote interferon-stimulated genes (ISG) expression [ 70 ]. Consistent with these observations, human patients with sarcopenia display increased levels of circulating cell-free mtDNA, positively correlating with plasma interleukin IL-6 and IL-8 [ 71 ].…”

Section: Impairment Of Damage Sensors and Increase In Alarm Signaling...mentioning

confidence: 70%

Inflammaging: Implications in Sarcopenia

Antuña

Cachán-Vega

Bermejo-Millo

et al. 2022

IJMS

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In a world in which life expectancy is increasing, understanding and promoting healthy aging becomes a contemporary demand. In the elderly, a sterile, chronic and low-grade systemic inflammation known as “inflammaging” is linked with many age-associated diseases. Considering sarcopenia as a loss of strength and mass of skeletal muscle related to aging, correlations between these two terms have been proposed. Better knowledge of the immune system players in skeletal muscle would help to elucidate their implications in sarcopenia. Characterizing the activators of damage sensors and the downstream effectors explains the inference with skeletal muscle performance. Sarcopenia has also been linked to chronic diseases such as diabetes, metabolic syndrome and obesity. Implications of inflammatory signals from these diseases negatively affect skeletal muscle. Autophagic mechanisms are closely related with the inflammasome, as autophagy eliminates stress signaling sent by damage organelles, but also acts with an immunomodulatory function affecting immune cells and cytokine release. The use of melatonin, an antioxidant, ROS scavenger and immune and autophagy modulator, or senotherapeutic compounds targeting senescent cells could represent strategies to counteract inflammation. This review aims to present the many factors regulating skeletal muscle inflammaging and their major implications in order to understand the molecular mechanisms involved in sarcopenia.

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Section: Impairment Of Damage Sensors and Increase In Alarm Signaling...mentioning

confidence: 70%

Inflammaging: Implications in Sarcopenia

Antuña

Cachán-Vega

Bermejo-Millo

et al. 2022

IJMS

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“…This underlines cfDNA relationship with inflammation and, indirectly, also with the functional performance of the older adult. To date, most research has focused on the determination of the cut off and AUC values for circulating cell free mtDNA (ccf-MtDNA)in older adult sarcopenia and the AUC value of 0.726 was reported ( 62 ). By contrast, our research focused on cfDNA and its potential application in the early diagnosis of sarcopenia might be indicated by a high value of AUC (0.689).…”

Section: Discussionmentioning

confidence: 99%

Diagnostics of inflammaging in relation to sarcopenia

Morawin,

Tylutka,

Bielewicz

et al. 2023

Front. Public Health

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One of the theories about aging focuses on the immune response and relates to the activation of subclinical and chronic inflammation. This study was designed to investigate the relationship between inflammation and sarcopenia and to evaluate the influence of lifestyle on the inflammatory profile. Finally, therapeutic strategies to counteract the pathophysiological effect of skeletal muscle aging were also indicated. One hundred seventy-three individuals aged 71.5 ± 6.8 years were divided into two groups: sarcopenia and probable sarcopenia (n = 39) and no sarcopenia (n = 134). Sarcopenia was assessed according to the algorithm of the European Working Group on Sarcopenia in the older adults 2. C-reactive protein (CRP) (p = 0.011) and CRP/albumin ratio (p = 0.030) as well as IL-1β (p = 0.002), cfDNA (p < 0.001) and bilirubin levels (p = 0.002) were significantly higher in the sarcopenia group as opposed to the no sarcopenia group. No significant differences were observed between groups in the concentration of TNFα (p = 0.429) and IL-6 (p = 0.300). An inverse correlation was found between gait speed and cfDNA (rs = −0.234, p < 0.01) and IL-1β (rs = −0.263, p < 0.01). The ROC analysis of cfDNA, CRP, IL-1β and bilirubin ranged from 0.6 to 0.7, which confirms the association between sarcopenia and inflammatory mediators and indicates high clinical usefulness of cfDNA and bilirubin in sarcopenia prediction. We also indicated a link between inflammation and fitness level in the older adult thereby providing evidence that lifestyle exercise should be a key therapeutic strategy in sarcopenia prevention.

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“…Free-circulating mtDNA (cf-mtDNA) is another favored non-invasive biomarker for multiple diseases; for example, it has been used to diagnose various cancers [ 64 , 65 , 66 , 67 ]. Recently, cf-mtDNA has been used as a predictive marker of the age-related phenotype [ 68 , 69 , 70 ].…”

Section: Inducers and Key Signatures Of Cellular Senescencementioning

confidence: 99%

The Molecular Mechanisms in Senescent Cells Induced by Natural Aging and Ionizing Radiation

Ibragimova,

Kussainova,

Aripova

et al. 2024

Cells

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This review discusses the relationship between cellular senescence and radiation exposure. Given the wide range of ionizing radiation sources encountered by people in professional and medical spheres, as well as the influence of natural background radiation, the question of the effect of radiation on biological processes, particularly on aging processes, remains highly relevant. The parallel relationship between natural and radiation-induced cellular senescence reveals the common aspects underlying these processes. Based on recent scientific data, the key points of the effects of ionizing radiation on cellular processes associated with aging, such as genome instability, mitochondrial dysfunction, altered expression of miRNAs, epigenetic profile, and manifestation of the senescence-associated secretory phenotype (SASP), are discussed. Unraveling the molecular mechanisms of cellular senescence can make a valuable contribution to the understanding of the molecular genetic basis of age-associated diseases in the context of environmental exposure.

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Altered levels of circulating mitochondrial DNA in elderly people with sarcopenia: Association with mitochondrial impairment

Cited by 25 publications

References 30 publications

Inflammaging: Implications in Sarcopenia

Inflammaging: Implications in Sarcopenia

Diagnostics of inflammaging in relation to sarcopenia

The Molecular Mechanisms in Senescent Cells Induced by Natural Aging and Ionizing Radiation

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