Altered low-frequency brain rhythms precede changes in gamma power during tauopathy

Rodents’ visual gamma as a biomarker of pathological neural conditions

“…Dashed lines indicate the aperiodic (1/f-like) component of V1 LFP spectra (Donoghue et al, 2020), on top of which the narrow and broad gamma bands are displayed based on the presented visual contrast. r gamma phase locking (within and between hemispheres) ↓ r gamma-spike coherence between homotopic V1 ↓ r theta-gamma cross-frequency coupling between homotopic V1 ↓ (Adaikkan et al, 2022) rTg4510 mice r gamma power in response to flickering contrast gratings ↓ r narrow gamma band unaltered (Rodrigues et al, 2022) 2018; Hasenstaub et al, 2005;Leung, 1982;Moca et al, 2014;Pafundo et al, 2013;Rotaru et al, 2011;Salkoff et al, 2015;Tiesinga & Sejnowski, 2009;Wulff et al, 2009). It is, therefore, safest to assume that they can both possibly provide a working machinery employed by the neocortex at need in different contexts, brain areas or animal species.…”

“…Adaikkan et al (2022) found enhanced gamma oscillations during novelty discrimination in healthy mice but compromised gamma coherence and synchronization in AD models. On the other hand, Rodrigues et al (2022) explored visual processing in a tauopathy mouse model, noting progressive reductions in gamma power. Interestingly, a distinct form of gamma activity (i.e.…”

“…In a recent paper, Rodrigues et al. (2022) instead investigated the alterations of visual processing in a mouse model of tauopathy (double transgenic rTg4510). They found that, in response to flickering contrast gratings, gamma (defined as 30–50 Hz) power was increasingly reduced as the pathology progressed.…”

“…On the other hand, Rodrigues et al. (2022) explored visual processing in a tauopathy mouse model, noting progressive reductions in gamma power. Interestingly, a distinct form of gamma activity (i.e.…”