2015
DOI: 10.1016/j.gene.2015.07.053
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Altered microRNA expression profile in hepatitis B virus-related hepatocellular carcinoma

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Cited by 9 publications
(8 citation statements)
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“…Taking into account the role in cancer [36,37,38,39,40,41,42,43,44,45,46] of the miRNAs identified in the discovery phase, we further investigated the expression by RT-qPCR of the 13 miRNA candidates in a cohort of 60 matched samples, (30 HCC+ vs. 30 HCC−) obtained at T0 and T1. The time difference of the mean obtained from repeated measures of the selected miRNAs in HCC+ vs HCC− patients, confirmed by bootstrap cross validation analysis on 1000 samples, evidenced the significant changes in miR-3197 and miR-1228-3p when analyzing the raw Cq expression.…”
Section: Discussionmentioning
confidence: 99%
“…Taking into account the role in cancer [36,37,38,39,40,41,42,43,44,45,46] of the miRNAs identified in the discovery phase, we further investigated the expression by RT-qPCR of the 13 miRNA candidates in a cohort of 60 matched samples, (30 HCC+ vs. 30 HCC−) obtained at T0 and T1. The time difference of the mean obtained from repeated measures of the selected miRNAs in HCC+ vs HCC− patients, confirmed by bootstrap cross validation analysis on 1000 samples, evidenced the significant changes in miR-3197 and miR-1228-3p when analyzing the raw Cq expression.…”
Section: Discussionmentioning
confidence: 99%
“…Recently, high-throughput array analyses have clearly demonstrated that miR-4417 is upregulated in many human cancers, such as breast cancer, prostate cancer, and gastrointestinal cancer [13–16]. Keon Uk Park et al reported that miR-4417 was upregulated in HCC tissues compared with non-cancerous liver tissue samples by using a microarray-based genome-wide miRNA analysis [11]. Here, we further examined the expression of miR-4417 in HCC cell lines, and confirmed that endogenous miR-4417 in HCC cell lines is indeed upregulated compared with the normal liver cell line HL-7702.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, miR-21 enhances cell proliferation, invasion, and metastasis in HCC cells and xenograft tumor growth in mouse models, providing a candidate target for cancer gene therapy [10]. miR-4417 is a newly discovered miRNA that was reported to be upregulated in HCC tissues compared with adjacent normal tissues [11]. It was also reported that the top 5 putative targets of miR-4417 were SOS1 , FAF2 , PAXIP1 , C1orf95 , and WDR48 [11].…”
Section: Introductionmentioning
confidence: 99%
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“…About 600,000 patients die every year due to HCC . The current available modalities to treat HCC include surgical removal of effected areas followed by radiotherapy or chemotherapy with 18% five‐year survival rate which shows the limited efficacy of cancer modalities against HCC . Currently, sorafenib is the only Food and Drug Administration approved drug for treatment of HCC.…”
Section: Introductionmentioning
confidence: 99%