Altered Neutrophil Phagocytic Function in Burn Patients

Grogan, James B.

doi:10.1097/00005373-197609000-00009

Cited by 63 publications

(20 citation statements)

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“…19, 2006 BURN WOUND INFECTIONS 409 of systemic inflammatory response syndrome and multiple-organ dysfunction syndrome. Neutrophil chemotaxis and intracellular killing are impaired following major burns (1,173,174). Diminished cytotoxic activity follows from a surge of degranulation early after injury and a subsequent inability to replenish intralysosomal enzymes and defensins (173,362).…”

Section: Innate Immune System Response To Burn Injurymentioning

confidence: 99%

Burn Wound Infections

Church

Elsayed

Reid³

et al. 2006

Clin Microbiol Rev

1,623

1,345

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SUMMARYBurns are one of the most common and devastating forms of trauma. Patients with serious thermal injury require immediate specialized care in order to minimize morbidity and mortality. Significant thermal injuries induce a state of immunosuppression that predisposes burn patients to infectious complications. A current summary of the classifications of burn wound infections, including their diagnosis, treatment, and prevention, is given. Early excision of the eschar has substantially decreased the incidence of invasive burn wound infection and secondary sepsis, but most deaths in severely burn-injured patients are still due to burn wound sepsis or complications due to inhalation injury. Burn patients are also at risk for developing sepsis secondary to pneumonia, catheter-related infections, and suppurative thrombophlebitis. The introduction of silver-impregnated devices (e.g., central lines and Foley urinary catheters) may reduce the incidence of nosocomial infections due to prolonged placement of these devices. Improved outcomes for severely burned patients have been attributed to medical advances in fluid resuscitation, nutritional support, pulmonary and burn wound care, and infection control practices.

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Section: Innate Immune System Response To Burn Injurymentioning

confidence: 99%

Burn Wound Infections

Church

Elsayed

Reid³

et al. 2006

Clin Microbiol Rev

1,623

1,345

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“…This organism is one of the leading causes of nosocomial pneumonia in adult and pediatric critical care units, as well as a major etiologic agent of pneumonia in neutropenic patients (1,17,20). In addition, its persistent colonization has been implicated in the chronic proinflammatory state and the progressive decline in pulmonary function in the airways of cystic fibrosis (CF) patients (7,20,21).…”

mentioning

confidence: 99%

CXC Chemokine Receptor CXCR2 Is Essential for Protective Innate Host Response in MurinePseudomonas aeruginosaPneumonia

et al. 2000

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“…[21][22][23] Neutrophil dysfunction has also been reported during major burns, 24,25 including reduction of both chemotaxis and degradation of phagocytosed pathogens. 26 Following burn injury, macrophages upregulate expression of PGE 2 and downregulate expression of the proinflammatory cytokine IL-12. 27 This shift away from a proinflammatory response results in reduced functionality and decreased MHC class II expression on antigen-presenting cells with consequent disruption of coordination of the adaptive immune response.…”

Section: Systemic Responsementioning

confidence: 99%