Altered pulmonary epithelial permeability in canine radiation lung injury

Idbaïh, Ahmed; El‐Khatib, Ellen; Logus, J. W.; Man, Godfrey C.W.; Jacques, J.; Man, S. F. Paul

doi:10.1152/jappl.1986.61.3.971

Cited by 18 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Histologic examinations have revealed interstitial edema and thickening of the alveolar capillary membrane and an alveolar surface lined by a proteinacous exudate following irradiation of the lungs (31,32). Later, a fibrotic reaction is characterized by interstitial collagen deposition, thickening of the vascular walls, and vascular occlusion (33).…”

Section: Discussionmentioning

confidence: 99%

Pulmonary function changes in lung-cancer patients treated with radiation with or without carboplatin.

Groen

Mark²,

Leest³

et al. 1995

Am J Respir Crit Care Med

View full text Add to dashboard Cite

In order to examine changes in pulmonary function in patients with locally advanced non-small-cell lung cancer (NSCLC) before, during, and after standard radiotherapy or combined chemoradiotherapy, we conducted a prospective study involving patients with such cancer, who were treated with radiation alone or with concurrent radiation and carboplatin from October 1992 to February 1994 at the University Hospital in Groningen, the Netherlands. Thirty-five patients were treated. Two patients were excluded because of pulmonary emphysema. Pretreatment values of TLC, VC, the gas-transfer coefficient (Kco), the pulmonary diffusing membrane factor (Dm), and pulmonary capillary blood volume (Vcap) were lower than in normal subjects and patients with chemotherapy-naive germ-cell carcinoma who had a similar pulmonary tumor load as the result of hematogenous metastases. The NSCLC patients' reduced Kco was explained by a decrease in Dm, a measure of alveolar-capillary membrane disturbance, and a similar decrease in Vcap. Pretreatment TLC did not correlate with Vcap or Dm, indicating extra- rather than intrapulmonary vascular and lymphatic obstruction as an explanation for the reduced Vcap and Dm. Locally advanced NSCLC was treated with radiation (n = 16) or combined continuous carboplatin infusion and radiation (n = 17). No changes in TLC, VC, Kco, Dm, or Vcap were observed during and 2 wk after the end of either treatment, nor were any differences in pulmonary function observed with the two treatments, indicating an absence of additional acute pulmonary toxicity caused by continuously infused carboplatin in this patient group.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

Section: Discussionmentioning

confidence: 99%

Pulmonary function changes in lung-cancer patients treated with radiation with or without carboplatin.

Groen

Mark²,

Leest³

et al. 1995

Am J Respir Crit Care Med

View full text Add to dashboard Cite

show abstract

“…In normal nonsmoking subjects, Monaghan et al (53) found a mean half-clearance time of 52 min (range 20 -132 min); in diseased lung this was reduced to 5 min (range 2-26 min). In contrast, animal studies of irradiation and amiodaron-induced lung injury have shown a retarded clearance (2,24,77,90). Clinical studies after radiotherapy against the thorax and of amiodaron-induced pulmonary toxicity have, however, found increased DTPA clearance (23,83,84,99).…”

Section: Active Regulation Of Lung Blood Flowmentioning

confidence: 99%

Physiological imaging of the lung: single-photon-emission computed tomography (SPECT)

Petersson

Sánchez-Crespo²,

Larsson³

et al. 2007

Journal of Applied Physiology

120

View full text Add to dashboard Cite

Petersson J, Sá nchez-Crespo A, Larsson SA, Mure M. Physiological imaging of the lung: single-photon-emission computed tomography (SPECT). J Appl Physiol 102: 468 -476, 2007. First published September 21, 2006; doi:10.1152/japplphysiol.00732.2006.-Emission tomography provides threedimensional, quantitative images of the distribution of radiotracers used to mark physiological, metabolic, or pathological processes. Quantitative single photon emission computed tomography (SPECT) requires correction for the imagedegrading effects due to photon attenuation and scatter. Phantom experiments have shown that radioactive concentrations can be assessed within some percentage of the true value when relevant corrections are applied. SPECT is widely spread, and radiotracers are available that are easy to use and comparably inexpensive. Compared with other methods, SPECT suffers from a lower spatial resolution, and the time required for image acquisition is longer than for some alternative methods. In contrast to some other methods, SPECT allows simultaneous imaging of more than one process, e.g., both regional blood flow and ventilation, for the whole lung. SPECT has been used to explore the influence of posture and clinical interventions on the spatial distribution of lung blood flow and ventilation. Lung blood flow is typically imaged using macroaggregates of albumin. Both radioactive gases and particulate aerosols labeled with radioactivity have been used for imaging of regional ventilation. However, all radiotracers are not equally suited for quantitative measurements; all have specific advantages and limitations. With SPECT, both blood flow and ventilation can be marked with radiotracers that remain fixed in the lung tissue, which allows tracer administration during conditions different from those at image registration. All SPECT methods have specific features that result from the used radiotracer, the manner in which it is administered, and how images are registered and analyzed. respiratory physiology; regional blood flow; pulmonary ventilation; pulmonary gas exchange; radionuclide imaging THE NONUNIFORM DISTRIBUTIONS of regional lung blood flow and ventilation were first demonstrated utilizing radioactive tracers (radiotracers) and external scintillation detectors that registered the distribution of radioactivity within the lung (10,14,43,93). Later the development of the gamma camera allowed twodimensional imaging of the distribution of radiotracers (58). In the mid to late 1970s, both single-photon-emission computed tomography (SPECT) and positron emission tomography (PET) were developed, offering three-dimensional images of the in vivo distribution of radioactivity. These techniques can be used to study, for example, the three-dimensional distribution of regional blood flow or regional ventilation with a high spatial resolution. In this article we will first briefly explain the principles and characteristics of the SPECT method and second review studies that exemplifies how SPECT has been used to increase our unde...

show abstract

“…Several investigators have postulated that 99mTcDTPA molecules traverse the alveolar-capillary barrier through the epithelial layer [14,15]. In a recent study, we showed that swelling of type I epithelium can possibly attenuate the passage of 99mTcDTPA molecules through the alveolar-capillary barrier [16].…”

Section: Discussionmentioning

confidence: 72%

Chronic Sidestream Cigarette Smoke Exposure Causes Lung Injury in Rabbits

et al. 1992

View full text Add to dashboard Cite

The effects of sidestream cigarette smoke (SSCS) (a 15-min exposure per day for 20 days) were determined on markers of lung injury in New Zealand white rabbits (n = 9) and a control group (n = 6). The SSCS consisted of air and smoke which were aspirated by syringe from a funnel inverted over a lit cigarette. The rabbits were placed in an environmental chamber into which 3 liters of SSCS were injected over a 15-min period each day. Chronic SSCS caused an increase (p < 0.05) in pulmonary epithelial clearance (k) of technetiumlabeled diethylenetriamine pentaacetate ( 99m TcDTPA); k = 0.83 (±0.07) for the SSCS-exposed group and 0.66 ( & p l u s m n ; 0.02) for the control group. This increase in lung permeability was accompanied by an increase in bronchoalveolar lavage (BAL) white cell count; SSCS = 83,353 ( ± 11,954) cells/mm3 BAL fluid versus control = 16,450 (± 6,683) cells/mm3 BAL fluid and an increase in BAL leukotriene E4; SSCS = 742 (± 285) pg/ml BAL fluid compared with 76 (± 2) pg/ml BAL fluid for controls. Cultured SSCS alveolar macrophages (AMs) produced more superoxide (O 2 ); 2.4 (± 0.8) nmol O 2 /10 6 AMs versus 0.4 (± 0.2) nmol O 2 /10 6 AMs for controls after incubation for 18 h with 10 μg/ml lipopolysaccharide. Electron microscopy demonstrated that the airway mucosa of SSCS rabbits was infiltrated by eosinophils, and light microscopy showed focal clusters of neutrophils in perivascular and capillary spaces. It is concluded that SSCS exposure can induce lung injury.

show abstract

Altered pulmonary epithelial permeability in canine radiation lung injury

Cited by 18 publications

References 0 publications

Pulmonary function changes in lung-cancer patients treated with radiation with or without carboplatin.

Pulmonary function changes in lung-cancer patients treated with radiation with or without carboplatin.

Physiological imaging of the lung: single-photon-emission computed tomography (SPECT)

Chronic Sidestream Cigarette Smoke Exposure Causes Lung Injury in Rabbits

Contact Info

Product

Resources

About